Gene name:
COL12A1 (COL12A1L) ;
Protein name:
Collagen alpha-1(XII) chain ;
Alternative:
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Trimer of identical chains each containing 190 kDa of non-triple-helical sequences.
Function:
Type XII collagen interacts with type I collagen-containing fibrils, the COL1 domain could be associated with the surface of the fibrils, and the COL2 and NC3 domains may be localized in the perifibrillar matrix.
Subcellular Location:
Secreted
extracellular space
extracellular matrix
Protein Attributes:
50:
MRSRLPPALA | ALGAALLLSS | IEAEVDPPSD | LNFKIIDENT | VHMSWAKPVD |
100:
PIVGYRITVD | PTTDGPTKEF | TLSASTTETL | LSELVPETEY | VVTITSYDEV |
150:
EESVPVIGQL | TIQTGSSTKP | VEKKPGKTEI | QKCSVSAWTD | LVFLVDGSWS |
200:
VGRNNFKYIL | DFIAALVSAF | DIGEEKTRVG | VVQYSSDTRT | EFNLNQYYQR |
250:
DELLAAIKKI | PYKGGNTMTG | DAIDYLVKNT | FTESAGARVG | FPKVAIIITD |
300:
GKSQDEVEIP | ARELRNVGVE | VFSLGIKAAD | AKELKQIAST | PSLNHVFNVA |
350:
NFDAIVDIQN | EIISQVCSGV | DEQLGELVSG | EEVVEPPSNL | IAMEVSSKYV |
400:
KLNWNPSPSP | VTGYKVILTP | MTAGSRQHAL | SVGPQTTTLS | VRDLSADTEY |
450:
QISVSAMKGM | TSSEPISIME | KTQPMKVQVE | CSRGVDIKAD | IVFLVDGSYS |
500:
IGIANFVKVR | AFLEVLVKSF | EISPNRVQIS | LVQYSRDPHT | EFTLKKFTKV |
550:
EDIIEAINTF | PYRGGSTNTG | KAMTYVREKI | FVPSKGSRSN | VPKVMILITD |
600:
GKSSDAFRDP | AIKLRNSDVE | IFAVGVKDAV | RSELEAIASP | PAETHVFTVE |
650:
DFDAFQRISF | ELTQSICLRI | EQELAAIKKK | AYVPPKDLSF | SEVTSYGFKT |
700:
NWSPAGENVF | SYHITYKEAA | GDDEVTVVEP | ASSTSVVLSS | LKPETLYLVN |
750:
VTAEYEDGFS | IPLAGEETTE | EVKGAPRNLK | VTDETTDSFK | ITWTQAPGRV |
800:
LRYRIIYRPV | AGGESREVTT | PPNQRRRTLE | NLIPDTKYEV | SVIPEYFSGP |
850:
GTPLTGNAAT | EEVRGNPRDL | RVSDPTTSTM | KLSWSGAPGK | VKQYLVTYTP |
900:
VAGGETQEVT | VRGDTTNTVL | QGLKEGTQYA | LSVTALYASG | AGDALFGEGT |
950:
TLEERGSPQD | LVTKDITDTS | IGAYWTSAPG | MVRGYRVSWK | SLYDDVDTGE |
1000:
KNLPEDAIHT | MIENLQPETK | YRISVFATYS | SGEGEPLTGD | ATTELSQDSK |
1050:
TLKVDEETEN | TMRVTWKPAP | GKVVNYRVVY | RPHGRGKQMV | AKVPPTVTST |
1100:
VLKRLQPQTT | YDITVLPIYK | MGEGKLRQGS | GTTASRFKSP | RNLKTSDPTM |
1150:
SSFRVTWEPA | PGEVKGYKVT | FHPTGDDRRL | GELVVGPYDN | TVVLEELRAG |
1200:
TTYKVNVFGM | FDGGESSPLV | GQEMTTLSDT | TVMPILSSGM | ECLTRAEADI |
1250:
VLLVDGSWSI | GRANFRTVRS | FISRIVEVFD | IGPKRVQIAL | AQYSGDPRTE |
1300:
WQLNAHRDKK | SLLQAVANLP | YKGGNTLTGM | ALNFIRQQNF | RTQAGMRPRA |
1350:
RKIGVLITDG | KSQDDVEAPS | KKLKDEGVEL | FAIGIKNADE | VELKMIATDP |
1400:
DDTHAYNVAD | FESLSRIVDD | LTINLCNSVK | GPGDLEAPSN | LVISERTHRS |
1450:
FRVSWTPPSD | SVDRYKVEYY | PVSGGKRQEF | YVSRMETSTV | LKDLKPETEY |
1500:
VVNVYSVVED | EYSEPLKGTE | KTLPVPVVSL | NIYDVGPTTM | HVQWQPVGGA |
1550:
TGYILSYKPV | KDTEPTRPKE | VRLGPTVNDM | QLTDLVPNTE | YAVTVQAVLH |
1600:
DLTSEPVTVR | EVTLPLPRPQ | DLKLRDVTHS | TMNVFWEPVP | GKVRKYIVRY |
1650:
KTPEEDVKEV | EVDRSETSTS | LKDLFSQTLY | TVSVSAVHDE | GESPPVTAQE |
1700:
TTRPVPAPTN | LKITEVTSEG | FRGTWDHGAS | DVSLYRITWA | PFGSSDKMET |
1750:
ILNGDENTLV | FENLNPNTIY | EVSITAIYPD | ESESDDLIGS | ERTLPILTTQ |
1800:
APKSGPRNLQ | VYNATSNSLT | VKWDPASGRV | QKYRITYQPS | TGEGNEQTTT |
1850:
IGGRQNSVVL | QKLKPDTPYT | ITVSSLYPDG | EGGRMTGRGK | TKPLNTVRNL |
1900:
RVYDPSTSTL | NVRWDHAEGN | PRQYKLFYAP | AAGGPEELVP | IPGNTNYAIL |
1950:
RNLQPDTSYT | VTVVPVYTEG | DGGRTSDTGR | TLMRGLARNV | QVYNPTPNSL |
2000:
DVRWDPAPGP | VLQYRVVYSP | VDGTRPSESI | VVPGNTRMVH | LERLIPDTLY |
2050:
SVNLVALYSD | GEGNPSPAQG | RTLPRSGPRN | LRVFGETTNS | LSVAWDHADG |
2100:
PVQQYRIIYS | PTVGDPIDEY | TTVPGRRNNV | ILQPLQPDTP | YKITVIAVYE |
2150:
DGDGGHLTGN | GRTVGLLPPQ | NIHISDEWYT | RFRVSWDPSP | SPVLGYKIVY |
2200:
KPVGSNEPME | AFVGEMTSYT | LHNLNPSTTY | DVNVYAQYDS | GLSVPLTDQG |
2250:
TTLYLNVTDL | KTYQIGWDTF | CVKWSPHRAA | TSYRLKLSPA | DGTRGQEITV |
2300:
RGSETSHCFT | GLSPDTDYGV | TVFVQTPNLE | GPGVSVKEHT | TVKPTEAPTE |
2350:
PPTPPPPPTI | PPARDVCKGA | KADIVFLTDA | SWSIGDDNFN | KVVKFIFNTV |
2400:
GGFDEISPAG | IQVSFVQYSD | EVKSEFKLNT | YNDKALALGA | LQNIRYRGGN |
2450:
TRTGKALTFI | KEKVLTWESG | MRKNVPKVLV | VVTDGRSQDE | VKKAALVIQQ |
2500:
SGFSVFVVGV | ADVDYNELAN | IASKPSERHV | FIVDDFESFE | KIEDNLITFV |
2550:
CETATSSCPL | IYLDGYTSPG | FKMLEAYNLT | EKNFASVQGV | SLESGSFPSY |
2600:
SAYRIQKNAF | VNQPTADLHP | NGLPPSYTII | LLFRLLPETP | SDPFAIWQIT |
2650:
DRDYKPQVGV | IADPSSKTLS | FFNKDTRGEV | QTVTFDTEEV | KTLFYGSFHK |
2700:
VHIVVTSKSV | KIYIDCYEII | EKDIKEAGNI | TTDGYEILGK | LLKGERKSAA |
2750:
FQIQSFDIVC | SPVWTSRDRC | CDIPSRRDEG | KCPAFPNSCT | CTQDSVGPPG |
2800:
PPGPAGGPGA | KGPRGERGIS | GAIGPPGPRG | DIGPPGPQGP | PGPQGPNGLS |
2850:
IPGEQGRQGM | KGDAGEPGLP | GRTGTPGLPG | PPGPMGPPGD | RGFTGKDGAM |
2900:
GPRGPPGPPG | SPGSPGVTGP | SGKPGKPGDH | GRPGPSGLKG | EKGDRGDIAS |
2950:
QNMMRAVARQ | VCEQLISGQM | NRFNQMLNQI | PNDYQSSRNQ | PGPPGPPGPP |
3000:
GSAGARGEPG | PGGRPGFPGT | PGMQGPPGER | GLPGEKGERG | TGSSGPRGLP |
3050:
GPPGPQGESR | TGPPGSTGSR | GPPGPPGRPG | NSGIRGPPGP | PGYCDSSQCA |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Rabbit
Chicken
Human
Bovine
Rat
Mouse
ELISA Kit for Human Collagen alpha-1(XII) chain
ELISA Kit for Human Collagen alpha-1(XII) chain
ELISA Kit for Human Collagen alpha-1(XII) chain
ELISA Kit for Human Collagen alpha-1(XII) chain
ELISA Kit for Human Collagen alpha-1(XII) chain
ELISA Kit for Human Collagen alpha-1(XII) chain
CLIA Kit for Human Collagen alpha-1(XII) chain
CLIA Kit for Human Collagen alpha-1(XII) chain
CLIA Kit for Human Collagen alpha-1(XII) chain
CLIA Kit for Human Collagen alpha-1(XII) chain
CLIA Kit for Human Collagen alpha-1(XII) chain
CLIA Kit for Human Collagen alpha-1(XII) chain
Polyclonal Antibody for Human Collagen alpha-1(XII) chain
Polyclonal Antibody for Human Collagen alpha-1(XII) chain
Polyclonal Antibody for Human Collagen alpha-1(XII) chain
Polyclonal Antibody for Human Collagen alpha-1(XII) chain
Polyclonal Antibody for Human Collagen alpha-1(XII) chain
Polyclonal Antibody for Human Collagen alpha-1(XII) chain
Monoclonal Antibody for Human Collagen alpha-1(XII) chain
Monoclonal Antibody for Human Collagen alpha-1(XII) chain
Monoclonal Antibody for Human Collagen alpha-1(XII) chain
Monoclonal Antibody for Human Collagen alpha-1(XII) chain
Monoclonal Antibody for Human Collagen alpha-1(XII) chain
Monoclonal Antibody for Human Collagen alpha-1(XII) chain
Protein for Human Collagen alpha-1(XII) chain
Protein for Human Collagen alpha-1(XII) chain
Protein for Human Collagen alpha-1(XII) chain
Protein for Human Collagen alpha-1(XII) chain
Protein for Human Collagen alpha-1(XII) chain
Protein for Human Collagen alpha-1(XII) chain
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
"Complete primary structure of two splice variants of collagen XII, and assignment of alpha 1(XII) collagen (COL12A1), alpha 1(IX) collagen (COL9A1), and alpha 1(XIX) collagen (COL19A1) to human chromosome 6q12-q13."
Gerecke D.R.
,
Olson P.F.
,
Koch M.
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Knoll J.H.M.
,
Taylor R.
,
Hudson D.L.
,
Champliaud M.-F.
,
Olsen B.R.
,
Burgeson R.E.
Genomics41:236-242(1997)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2);PROTEIN SEQUENCE OF 1280-1295; 1782-1801 AND 2906-2916;VARIANT SER-3058
2.
"The DNA sequence and analysis of human chromosome 6."
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Nature425:805-811(2003)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-9
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF 299-816 (ISOFORMS 1/4);TISSUE SPECIFICITY
tissue :
Cornea .
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 2567-2755 (ISOFORM 4)
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-2528 AND ASN-2679
tissue :
Liver .
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]