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Index > Protein center > COL12A1(Gene name) > Human
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  • COL12A1 (Gene name),
  • Collagen alpha-1(XII) chain (Protein name ),  COCA1_HUMAN from NCBI database.
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  • Gene name:
    COL12A1(COL12A1L);
    Protein name:
    Collagen alpha-1(XII) chain;
    Alternative:

    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Trimer of identical chains each containing 190 kDa of non-triple-helical sequences.
    Function:
    Type XII collagen interacts with type I collagen-containing fibrils, the COL1 domain could be associated with the surface of the fibrils, and the COL2 and NC3 domains may be localized in the perifibrillar matrix.
    Subcellular Location:
    Secreted extracellular space extracellular matrix
    Protein Attributes:
    Sequence length:
    3063
    Sequence:
    50:
    MRSRLPPALA | ALGAALLLSS | IEAEVDPPSD | LNFKIIDENT | VHMSWAKPVD | 
    100:
    PIVGYRITVD | PTTDGPTKEF | TLSASTTETL | LSELVPETEY | VVTITSYDEV | 
    150:
    EESVPVIGQL | TIQTGSSTKP | VEKKPGKTEI | QKCSVSAWTD | LVFLVDGSWS | 
    200:
    VGRNNFKYIL | DFIAALVSAF | DIGEEKTRVG | VVQYSSDTRT | EFNLNQYYQR | 
    250:
    DELLAAIKKI | PYKGGNTMTG | DAIDYLVKNT | FTESAGARVG | FPKVAIIITD | 
    300:
    GKSQDEVEIP | ARELRNVGVE | VFSLGIKAAD | AKELKQIAST | PSLNHVFNVA | 
    350:
    NFDAIVDIQN | EIISQVCSGV | DEQLGELVSG | EEVVEPPSNL | IAMEVSSKYV | 
    400:
    KLNWNPSPSP | VTGYKVILTP | MTAGSRQHAL | SVGPQTTTLS | VRDLSADTEY | 
    450:
    QISVSAMKGM | TSSEPISIME | KTQPMKVQVE | CSRGVDIKAD | IVFLVDGSYS | 
    500:
    IGIANFVKVR | AFLEVLVKSF | EISPNRVQIS | LVQYSRDPHT | EFTLKKFTKV | 
    550:
    EDIIEAINTF | PYRGGSTNTG | KAMTYVREKI | FVPSKGSRSN | VPKVMILITD | 
    600:
    GKSSDAFRDP | AIKLRNSDVE | IFAVGVKDAV | RSELEAIASP | PAETHVFTVE | 
    650:
    DFDAFQRISF | ELTQSICLRI | EQELAAIKKK | AYVPPKDLSF | SEVTSYGFKT | 
    700:
    NWSPAGENVF | SYHITYKEAA | GDDEVTVVEP | ASSTSVVLSS | LKPETLYLVN | 
    750:
    VTAEYEDGFS | IPLAGEETTE | EVKGAPRNLK | VTDETTDSFK | ITWTQAPGRV | 
    800:
    LRYRIIYRPV | AGGESREVTT | PPNQRRRTLE | NLIPDTKYEV | SVIPEYFSGP | 
    850:
    GTPLTGNAAT | EEVRGNPRDL | RVSDPTTSTM | KLSWSGAPGK | VKQYLVTYTP | 
    900:
    VAGGETQEVT | VRGDTTNTVL | QGLKEGTQYA | LSVTALYASG | AGDALFGEGT | 
    950:
    TLEERGSPQD | LVTKDITDTS | IGAYWTSAPG | MVRGYRVSWK | SLYDDVDTGE | 
    1000:
    KNLPEDAIHT | MIENLQPETK | YRISVFATYS | SGEGEPLTGD | ATTELSQDSK | 
    1050:
    TLKVDEETEN | TMRVTWKPAP | GKVVNYRVVY | RPHGRGKQMV | AKVPPTVTST | 
    1100:
    VLKRLQPQTT | YDITVLPIYK | MGEGKLRQGS | GTTASRFKSP | RNLKTSDPTM | 
    1150:
    SSFRVTWEPA | PGEVKGYKVT | FHPTGDDRRL | GELVVGPYDN | TVVLEELRAG | 
    1200:
    TTYKVNVFGM | FDGGESSPLV | GQEMTTLSDT | TVMPILSSGM | ECLTRAEADI | 
    1250:
    VLLVDGSWSI | GRANFRTVRS | FISRIVEVFD | IGPKRVQIAL | AQYSGDPRTE | 
    1300:
    WQLNAHRDKK | SLLQAVANLP | YKGGNTLTGM | ALNFIRQQNF | RTQAGMRPRA | 
    1350:
    RKIGVLITDG | KSQDDVEAPS | KKLKDEGVEL | FAIGIKNADE | VELKMIATDP | 
    1400:
    DDTHAYNVAD | FESLSRIVDD | LTINLCNSVK | GPGDLEAPSN | LVISERTHRS | 
    1450:
    FRVSWTPPSD | SVDRYKVEYY | PVSGGKRQEF | YVSRMETSTV | LKDLKPETEY | 
    1500:
    VVNVYSVVED | EYSEPLKGTE | KTLPVPVVSL | NIYDVGPTTM | HVQWQPVGGA | 
    1550:
    TGYILSYKPV | KDTEPTRPKE | VRLGPTVNDM | QLTDLVPNTE | YAVTVQAVLH | 
    1600:
    DLTSEPVTVR | EVTLPLPRPQ | DLKLRDVTHS | TMNVFWEPVP | GKVRKYIVRY | 
    1650:
    KTPEEDVKEV | EVDRSETSTS | LKDLFSQTLY | TVSVSAVHDE | GESPPVTAQE | 
    1700:
    TTRPVPAPTN | LKITEVTSEG | FRGTWDHGAS | DVSLYRITWA | PFGSSDKMET | 
    1750:
    ILNGDENTLV | FENLNPNTIY | EVSITAIYPD | ESESDDLIGS | ERTLPILTTQ | 
    1800:
    APKSGPRNLQ | VYNATSNSLT | VKWDPASGRV | QKYRITYQPS | TGEGNEQTTT | 
    1850:
    IGGRQNSVVL | QKLKPDTPYT | ITVSSLYPDG | EGGRMTGRGK | TKPLNTVRNL | 
    1900:
    RVYDPSTSTL | NVRWDHAEGN | PRQYKLFYAP | AAGGPEELVP | IPGNTNYAIL | 
    1950:
    RNLQPDTSYT | VTVVPVYTEG | DGGRTSDTGR | TLMRGLARNV | QVYNPTPNSL | 
    2000:
    DVRWDPAPGP | VLQYRVVYSP | VDGTRPSESI | VVPGNTRMVH | LERLIPDTLY | 
    2050:
    SVNLVALYSD | GEGNPSPAQG | RTLPRSGPRN | LRVFGETTNS | LSVAWDHADG | 
    2100:
    PVQQYRIIYS | PTVGDPIDEY | TTVPGRRNNV | ILQPLQPDTP | YKITVIAVYE | 
    2150:
    DGDGGHLTGN | GRTVGLLPPQ | NIHISDEWYT | RFRVSWDPSP | SPVLGYKIVY | 
    2200:
    KPVGSNEPME | AFVGEMTSYT | LHNLNPSTTY | DVNVYAQYDS | GLSVPLTDQG | 
    2250:
    TTLYLNVTDL | KTYQIGWDTF | CVKWSPHRAA | TSYRLKLSPA | DGTRGQEITV | 
    2300:
    RGSETSHCFT | GLSPDTDYGV | TVFVQTPNLE | GPGVSVKEHT | TVKPTEAPTE | 
    2350:
    PPTPPPPPTI | PPARDVCKGA | KADIVFLTDA | SWSIGDDNFN | KVVKFIFNTV | 
    2400:
    GGFDEISPAG | IQVSFVQYSD | EVKSEFKLNT | YNDKALALGA | LQNIRYRGGN | 
    2450:
    TRTGKALTFI | KEKVLTWESG | MRKNVPKVLV | VVTDGRSQDE | VKKAALVIQQ | 
    2500:
    SGFSVFVVGV | ADVDYNELAN | IASKPSERHV | FIVDDFESFE | KIEDNLITFV | 
    2550:
    CETATSSCPL | IYLDGYTSPG | FKMLEAYNLT | EKNFASVQGV | SLESGSFPSY | 
    2600:
    SAYRIQKNAF | VNQPTADLHP | NGLPPSYTII | LLFRLLPETP | SDPFAIWQIT | 
    2650:
    DRDYKPQVGV | IADPSSKTLS | FFNKDTRGEV | QTVTFDTEEV | KTLFYGSFHK | 
    2700:
    VHIVVTSKSV | KIYIDCYEII | EKDIKEAGNI | TTDGYEILGK | LLKGERKSAA | 
    2750:
    FQIQSFDIVC | SPVWTSRDRC | CDIPSRRDEG | KCPAFPNSCT | CTQDSVGPPG | 
    2800:
    PPGPAGGPGA | KGPRGERGIS | GAIGPPGPRG | DIGPPGPQGP | PGPQGPNGLS | 
    2850:
    IPGEQGRQGM | KGDAGEPGLP | GRTGTPGLPG | PPGPMGPPGD | RGFTGKDGAM | 
    2900:
    GPRGPPGPPG | SPGSPGVTGP | SGKPGKPGDH | GRPGPSGLKG | EKGDRGDIAS | 
    2950:
    QNMMRAVARQ | VCEQLISGQM | NRFNQMLNQI | PNDYQSSRNQ | PGPPGPPGPP | 
    3000:
    GSAGARGEPG | PGGRPGFPGT | PGMQGPPGER | GLPGEKGERG | TGSSGPRGLP | 
    3050:
    GPPGPQGESR | TGPPGSTGSR | GPPGPPGRPG | NSGIRGPPGP | PGYCDSSQCA | 
    3063:
    SIPYNGQGYP | GSG
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    Pfam:
    SMR:
    MIM:
    UniGene:
    String:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Human Collagen alpha-1(XII) chain
    ELISA Kit for Human Collagen alpha-1(XII) chain
    ELISA Kit for Human Collagen alpha-1(XII) chain
    ELISA Kit for Human Collagen alpha-1(XII) chain
    ELISA Kit for Human Collagen alpha-1(XII) chain
    ELISA Kit for Human Collagen alpha-1(XII) chain
    CLIA Kit for Human Collagen alpha-1(XII) chain
    CLIA Kit for Human Collagen alpha-1(XII) chain
    CLIA Kit for Human Collagen alpha-1(XII) chain
    CLIA Kit for Human Collagen alpha-1(XII) chain
    CLIA Kit for Human Collagen alpha-1(XII) chain
    CLIA Kit for Human Collagen alpha-1(XII) chain
    Polyclonal Antibody for Human Collagen alpha-1(XII) chain
    Polyclonal Antibody for Human Collagen alpha-1(XII) chain
    Polyclonal Antibody for Human Collagen alpha-1(XII) chain
    Polyclonal Antibody for Human Collagen alpha-1(XII) chain
    Polyclonal Antibody for Human Collagen alpha-1(XII) chain
    Polyclonal Antibody for Human Collagen alpha-1(XII) chain
    Monoclonal Antibody for Human Collagen alpha-1(XII) chain
    Monoclonal Antibody for Human Collagen alpha-1(XII) chain
    Monoclonal Antibody for Human Collagen alpha-1(XII) chain
    Monoclonal Antibody for Human Collagen alpha-1(XII) chain
    Monoclonal Antibody for Human Collagen alpha-1(XII) chain
    Monoclonal Antibody for Human Collagen alpha-1(XII) chain
    Protein for Human Collagen alpha-1(XII) chain
    Protein for Human Collagen alpha-1(XII) chain
    Protein for Human Collagen alpha-1(XII) chain
    Protein for Human Collagen alpha-1(XII) chain
    Protein for Human Collagen alpha-1(XII) chain
    Protein for Human Collagen alpha-1(XII) chain

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Complete primary structure of two splice variants of collagen XII, and assignment of alpha 1(XII) collagen (COL12A1), alpha 1(IX) collagen (COL9A1), and alpha 1(XIX) collagen (COL19A1) to human chromosome 6q12-q13."
      Gerecke D.R. , Olson P.F. , Koch M. , Knoll J.H.M. , Taylor R. , Hudson D.L. , Champliaud M.-F. , Olsen B.R. , Burgeson R.E.
      Genomics41:236-242(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2);PROTEIN SEQUENCE OF 1280-1295; 1782-1801 AND 2906-2916;VARIANT SER-3058
    2. 2.
      "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J. , Palmer S.A. , Sims S.K. , Edwards C.A. , Ashurst J.L. , Wilming L. , Jones M.C. , Horton R. , Hunt S.E. , Scott C.E. , Gilbert J.G.R. , Clamp M.E. , Bethel G. , Milne S. , Ainscough R. , Almeida J.P. , Ambrose K.D. , Andrews T.D. , more...
      Nature425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    3. 3.
      "The chick and human collagen alpha1(XII) gene promoter -- activity of highly conserved regions around the first exon and in the first intron."
      Chiquet M. , Mumenthaler U. , Wittwer M. , Jin W. , Koch M.
      Eur. J. Biochem.257:362-371(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-9
    4. 4.
      "Type XII collagen contributes to diversities in human corneal and limbal extracellular matrices."
      Wessel H. , Anderson S. , Fite D. , Halvas E. , Hempel J. , SundarRaj N.
      Invest. Ophthalmol. Vis. Sci.38:2408-2422(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 299-816 (ISOFORMS 1/4);TISSUE SPECIFICITY
      tissue: Cornea.
    5. 5.
      "The mouse alpha 1(XII) and human alpha 1(XII)-like collagen genes are localized on mouse chromosome 9 and human chromosome 6."
      Oh S.P. , Taylor R.W. , Gerecke D.R. , Rochelle J.M. , Seldin M.F. , Olsen B.R.
      Genomics14:225-231(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 2567-2755 (ISOFORM 4)
    6. 6.
      "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
      Chen R. , Jiang X. , Sun D. , Han G. , Wang F. , Ye M. , Wang L. , Zou H.
      J. Proteome Res.8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-2528 AND ASN-2679
      tissue: Liver.
    7. 7.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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