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Index > Protein center > COL13A1(Gene name) > Human
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  • COL13A1 (Gene name),
  • Collagen alpha-1(XIII) chain (Protein name ),  CODA1_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    COL13A1;
    Protein name:
    Collagen alpha-1(XIII) chain;
    Alternative:
    COLXIIIA1;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Homotrimer; disulfide-linked. Nucleation of the type XIII collagen triple helix is likely to occur at the N-terminal region with triple helix formation proceeding from the N- to the C-terminus. Interacts with FN1, perlecan/HSPG2 and NID2.
    Function:
    Involved in cell-matrix and cell-cell adhesion interactions that are required for normal development. May participate in the linkage between muscle fiber and basement membrane. May play a role in endochondral ossification of bone and branching morphogenesis of lung. Binds heparin.
    Subcellular Location:
    Cell membrane Single-pass type II membrane protein
    Protein Attributes:
    Sequence length:
    717
    Sequence:
    50:
    MVAERTHKAA | ATGARGPGEL | GAPGTVALVA | ARAERGARLP | SPGSCGLLTL | 
    100:
    ALCSLALSLL | AHFRTAELQA | RVLRLEAERG | EQQMETAILG | RVNQLLDEKW | 
    150:
    KLHSRRRREA | PKTSPGCNCP | PGPPGPTGRP | GLPGDKGAIG | MPGRVGSPGD | 
    200:
    AGLSIIGPRG | PPGQPGTRGF | PGFPGPIGLD | GKPGHPGPKG | DMGLTGPPGQ | 
    250:
    PGPQGQKGEK | GQCGEYPHRE | CLSSMPAALR | SSQIIALKLL | PLLNSVRLAP | 
    300:
    PPVIKRRTFQ | GEQSQASIQG | PPGPPGPPGP | SGPLGHPGLP | GPMGPPGLPG | 
    350:
    PPGPKGDPGI | QGYHGRKGER | GMPGMPGKHG | AKGAPGIAVA | GMKGEPGIPG | 
    400:
    TKGEKGAEGS | PGLPGLLGQK | GEKGDAGNSI | GGGRGEPGPP | GLPGPPGPKG | 
    450:
    EAGVDGQVGP | PGQPGDKGER | GAAGEQGPDG | PKGSKGEPGK | GEMVDYNGNI | 
    500:
    NEALQEIRTL | ALMGPPGLPG | QIGPPGAPGI | PGQKGEIGLP | GPPGHDGEKG | 
    550:
    PRGKPGDMGP | PGPQGPPGKD | GPPGVKGENG | HPGSPGEKGE | KGETGQAGSP | 
    600:
    GEKGEAGEKG | NPGAEVPGLP | GPEGPPGPPG | LQGVPGPKGE | AGLDGAKGEK | 
    650:
    GFQGEKGDRG | PLGLPGASGL | DGRPGPPGTP | GPIGVPGPAG | PKGERGSKGD | 
    700:
    PGMTGPTGAA | GLPGLHGPPG | DKGNRGERGK | KGSRGPKGDK | GDQGAPGLDA | 
    717:
    PCPLGEDGLP | VQGCWNK
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    KEGG:
    Pfam:
    MIM:
    UniGene:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Human Collagen alpha-1(XIII) chain
    ELISA Kit for Human Collagen alpha-1(XIII) chain
    CLIA Kit for Human Collagen alpha-1(XIII) chain
    CLIA Kit for Human Collagen alpha-1(XIII) chain
    Polyclonal Antibody for Human Collagen alpha-1(XIII) chain
    Polyclonal Antibody for Human Collagen alpha-1(XIII) chain
    Monoclonal Antibody for Human Collagen alpha-1(XIII) chain
    Monoclonal Antibody for Human Collagen alpha-1(XIII) chain
    Protein for Human Collagen alpha-1(XIII) chain
    Protein for Human Collagen alpha-1(XIII) chain

    R&D Technical Data
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    Precision
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    Recovery
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    References
    1. 1.
      "A short sequence in the N-terminal region is required for the trimerization of type XIII collagen and is conserved in other collagenous transmembrane proteins."
      Snellman A. , Tu H. , Vaisanen T. , Kvist A.-P. , Huhtala P. , Pihlajaniemi T.
      EMBO J.19:5051-5059(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);SUBUNIT;SUBCELLULAR LOCATION
    2. 2.
      "The DNA sequence and comparative analysis of human chromosome 10."
      Deloukas P. , Earthrowl M.E. , Grafham D.V. , Rubenfield M. , French L. , Steward C.A. , Sims S.K. , Jones M.C. , Searle S. , Scott C. , Howe K. , Hunt S.E. , Andrews T.D. , Gilbert J.G.R. , Swarbreck D. , Ashurst J.L. , Taylor A. , Battles J. , more...
      Nature429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    3. 3.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 10)
      tissue: Testis.
    4. 4.
      "The alpha 1 chain of type XIII collagen consists of three collagenous and four noncollagenous domains, and its primary transcript undergoes complex alternative splicing."
      Pihlajaniemi T. , Tamminen M.
      J. Biol. Chem.265:16922-16928(1990) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 44-717 (ISOFORM 4);NUCLEOTIDE SEQUENCE [MRNA] OF 84-717 (ISOFORMS 8 AND 9)
      tissue: Endothelial cell.
    5. 5.
      "Partial characterization of a low molecular weight human collagen that undergoes alternative splicing."
      Pihlajaniemi T. , Myllyla R. , Seyer J. , Kurkinen M. , Prockop D.J.
      Proc. Natl. Acad. Sci. U.S.A.84:940-944(1987) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 457-717 (ISOFORM 5);NUCLEOTIDE SEQUENCE [MRNA] OF 573-717 (ISOFORMS 3/4/7/8)
      tissue: Fibrosarcoma.
    6. 6.
      "Gene structure for the alpha 1 chain of a human short-chain collagen (type XIII) with alternatively spliced transcripts and translation termination codon at the 5' end of the last exon."
      Tikka L. , Pihlajaniemi T. , Henttu P. , Prockop D.J. , Tryggvason K.
      Proc. Natl. Acad. Sci. U.S.A.85:7491-7495(1988) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 551-717 (ISOFORMS 6 AND 7);NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 551-717 (ISOFORMS 1/2);NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 566-771 (ISOFORMS 3/4/8)
    7. 7.
      "Characterization of the spectrum of alternative splicing of alpha 1 (XIII) collagen transcripts in HT-1080 cells and calvarial tissue resulted in identification of two previously unidentified alternatively spliced sequences, one previously unidentified exon, and nine new mRNA variants."
      Juvonen M. , Pihlajaniemi T.
      J. Biol. Chem.267:24693-24699(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ALTERNATIVE SPLICING
    8. 8.
      "Patterns of expression of the six alternatively spliced exons affecting the structures of the COL1 and NC2 domains of the alpha 1(XIII) collagen chain in human tissues and cell lines."
      Juvonen M. , Sandberg M. , Pihlajaniemi T.
      J. Biol. Chem.267:24700-24707(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ALTERNATIVE SPLICING
    9. 9.
      "Location and alternative splicing of type XIII collagen RNA in the early human placenta."
      Juvonen M. , Pihlajaniemi T. , Autio-Harmainen H.
      Lab. Invest.69:541-551(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ALTERNATIVE SPLICING;TISSUE SPECIFICITY
    10. 10.
      "Type XIII collagen is widely expressed in the adult and developing human eye and accentuated in the ciliary muscle, the optic nerve and the neural retina."
      Sandberg-Lall M. , Hagg P.O. , Wahlstrom I. , Pihlajaniemi T.
      Exp. Eye Res.70:401-410(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;TISSUE SPECIFICITY
    11. 11.
      "The type XIII collagen ectodomain is a 150-nm rod and capable of binding to fibronectin, nidogen-2, perlecan, and heparin."
      Tu H. , Sasaki T. , Snellman A. , Gohring W. , Pirila P. , Timpl R. , Pihlajaniemi T.
      J. Biol. Chem.277:23092-23099(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH FN1; HSPG2 AND NID2;HEPARIN-BINDING
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