Collagen alpha-1(XIII) chain (Protein name
), CODA1_HUMAN from NCBI database.
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Gene name:
COL13A1;
Protein name:
Collagen alpha-1(XIII) chain;
Alternative:
COLXIIIA1;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Homotrimer; disulfide-linked. Nucleation of the type XIII collagen triple helix is likely to occur at the N-terminal region with triple helix formation proceeding from the N- to the C-terminus. Interacts with FN1, perlecan/HSPG2 and NID2.
Function:
Involved in cell-matrix and cell-cell adhesion interactions that are required for normal development. May participate in the linkage between muscle fiber and basement membrane. May play a role in endochondral ossification of bone and branching morphogenesis of lung. Binds heparin.
Subcellular Location:
Cell membrane
Single-pass type II membrane protein
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Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);SUBUNIT;SUBCELLULAR LOCATION
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Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 10)
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Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 44-717 (ISOFORM 4);NUCLEOTIDE SEQUENCE [MRNA] OF 84-717 (ISOFORMS 8 AND 9)
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Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 457-717 (ISOFORM 5);NUCLEOTIDE SEQUENCE [MRNA] OF 573-717 (ISOFORMS 3/4/7/8)
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Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 551-717 (ISOFORMS 6 AND 7);NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 551-717 (ISOFORMS 1/2);NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 566-771 (ISOFORMS 3/4/8)
7.
"Characterization of the spectrum of alternative splicing of alpha 1 (XIII) collagen transcripts in HT-1080 cells and calvarial tissue resulted in identification of two previously unidentified alternatively spliced sequences, one previously unidentified exon, and nine new mRNA variants." Juvonen M.
,
Pihlajaniemi T.
J. Biol. Chem.267:24693-24699(1992)
[PubMed]
[Europe PMC]
[Abstract]
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Cited for: ALTERNATIVE SPLICING
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Cited for: FUNCTION;INTERACTION WITH FN1; HSPG2 AND NID2;HEPARIN-BINDING