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Index > Protein center > COL16A1(Gene name) > Human
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  • COL16A1 (Gene name),
  • Collagen alpha-1(XVI) chain (Protein name ),  COGA1_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    COL16A1(FP1572);
    Protein name:
    Collagen alpha-1(XVI) chain;
    Alternative:

    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Homotrimer. Interacts with FBN1, fibronectin and integrins ITGA1/ITGB1 and ITGA2/ITGB1. Integrin ITGA1/ITGB1 binds to a unique site within COL16A1 located close to its C-terminal end between collagenous domains COL1-COL3.
    Function:
    Involved in mediating cell attachment and inducing integrin-mediated cellular reactions, such as cell spreading and alterations in cell morphology.
    Subcellular Location:
    Secreted extracellular space extracellular matrix
    Protein Attributes:
    Sequence length:
    1604
    Sequence:
    50:
    MWVSWAPGLW | LLGLWATFGH | GANTGAQCPP | SQQEGLKLEH | SSSLPANVTG | 
    100:
    FNLIHRLSLM | KTSAIKKIRN | PKGPLILRLG | AAPVTQPTRR | VFPRGLPEEF | 
    150:
    ALVLTLLLKK | HTHQKTWYLF | QVTDANGYPQ | ISLEVNSQER | SLELRAQGQD | 
    200:
    GDFVSCIFPV | PQLFDLRWHK | LMLSVAGRVA | SVHVDCSSAS | SQPLGPRRPM | 
    250:
    RPVGHVFLGL | DAEQGKPVSF | DLQQVHIYCD | PELVLEEGCC | EILPAGCPPE | 
    300:
    TSKARRDTQS | NELIEINPQS | EGKVYTRCFC | LEEPQNSEVD | AQLTGRISQK | 
    350:
    AERGAKVHQE | TAADECPPCV | HGARDSNVTL | APSGPKGGKG | ERGLPGPPGS | 
    400:
    KGEKGARGND | CVRISPDAPL | QCAEGPKGEK | GESGALGPSG | LPGSTGEKGQ | 
    450:
    KGEKGDGGIK | GVPGKPGRDG | RPGEICVIGP | KGQKGDPGFV | GPEGLAGEPG | 
    500:
    PPGLPGPPGI | GLPGTPGDPG | GPPGPKGDKG | SSGIPGKEGP | GGKPGKPGVK | 
    550:
    GEKGDPCEVC | PTLPEGFQNF | VGLPGKPGPK | GEPGDPVPAR | GDPGIQGIKG | 
    600:
    EKGEPCLSCS | SVVGAQHLVS | STGASGDVGS | PGFGLPGLPG | RAGVPGLKGE | 
    650:
    KGNFGEAGPA | GSPGPPGPVG | PAGIKGAKGE | PCEPCPALSN | LQDGDVRVVA | 
    700:
    LPGPSGEKGE | PGPPGFGLPG | KQGKAGERGL | KGQKGDAGNP | GDPGTPGTTG | 
    750:
    RPGLSGEPGV | QGPAGPKGEK | GDGCTACPSL | QGTVTDMAGR | PGQPGPKGEQ | 
    800:
    GPEGVGRPGK | PGQPGLPGVQ | GPPGLKGVQG | EPGPPGRGVQ | GPQGEPGAPG | 
    850:
    LPGIQGLPGP | RGPPGPTGEK | GAQGSPGVKG | ATGPVGPPGA | SVSGPPGRDG | 
    900:
    QQGQTGLRGT | PGEKGPRGEK | GEPGECSCPS | QGDLIFSGMP | GAPGLWMGSS | 
    950:
    WQPGPQGPPG | IPGPPGPPGV | PGLQGVPGNN | GLPGQPGLTA | ELGSLPIEQH | 
    1000:
    LLKSICGDCV | QGQRAHPGYL | VEKGEKGDQG | IPGVPGLDNC | AQCFLSLERP | 
    1050:
    RAEEARGDNS | EGDPGCVGSP | GLPGPPGLPG | QRGEEGPPGM | RGSPGPPGPI | 
    1100:
    GPPGFPGAVG | SPGLPGLQGE | RGLTGLTGDK | GEPGPPGQPG | YPGATGPPGL | 
    1150:
    PGIKGERGYT | GSAGEKGEPG | PPGSEGLPGP | PGPAGPRGER | GPQGNSGEKG | 
    1200:
    DQGFQGQPGF | PGPPGPPGFP | GKVGSPGPPG | PQAEKGSEGI | RGPSGLPGSP | 
    1250:
    GPPGPPGIQG | PAGLDGLDGK | DGKPGLRGDP | GPAGPPGLMG | PPGFKGKTGH | 
    1300:
    PGLPGPKGDC | GKPGPPGSTG | RPGAEGEPGA | MGPQGRPGPP | GHVGPPGPPG | 
    1350:
    QPGPAGISAV | GLKGDRGATG | ERGLAGLPGQ | PGPPGHPGPP | GEPGTDGAAG | 
    1400:
    KEGPPGKQGF | YGPPGPKGDP | GAAGQKGQAG | EKGRAGMPGG | PGKSGSMGPV | 
    1450:
    GPPGPAGERG | HPGAPGPSGS | PGLPGVPGSM | GDMVNYDEIK | RFIRQEIIKM | 
    1500:
    FDERMAYYTS | RMQFPMEMAA | APGRPGPPGK | DGAPGRPGAP | GSPGLPGQIG | 
    1550:
    REGRQGLPGV | RGLPGTKGEK | GDIGIGIAGE | NGLPGPPGPQ | GPPGYGKMGA | 
    1600:
    TGPMGQQGIP | GIPGPPGPMG | QPGKAGHCNP | SDCFGAMPME | QQYPPMKTMK | 
    1604:
    GPFG
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    Pfam:
    KEGG:
    SMR:
    String:
    UniGene:
    MIM:
    Uniprot:
     
    FOR
    ELISA Kit for Human Collagen alpha-1(XVI) chain
    ELISA Kit for Human Collagen alpha-1(XVI) chain
    CLIA Kit for Human Collagen alpha-1(XVI) chain
    CLIA Kit for Human Collagen alpha-1(XVI) chain
    Polyclonal Antibody for Human Collagen alpha-1(XVI) chain
    Polyclonal Antibody for Human Collagen alpha-1(XVI) chain
    Monoclonal Antibody for Human Collagen alpha-1(XVI) chain
    Monoclonal Antibody for Human Collagen alpha-1(XVI) chain
    Protein for Human Collagen alpha-1(XVI) chain
    Protein for Human Collagen alpha-1(XVI) chain

    R&D Technical Data
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    Precision
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Recovery
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    References
    1. 1.
      "Cloning and chromosomal location of human alpha 1(XVI) collagen."
      Pan T.-C. , Zhang R.-Z. , Mattei M.-G. , Timpl R. , Chu M.-L.
      Proc. Natl. Acad. Sci. U.S.A.89:6565-6569(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANT LYS-62
      tissue: Fibroblast.
    2. 2.
      "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G. , Barlow K.F. , McLay K.E. , Kaul R. , Swarbreck D. , Dunham A. , Scott C.E. , Howe K.L. , Woodfine K. , Spencer C.C.A. , Jones M.C. , Gillson C. , Searle S. , Zhou Y. , Kokocinski F. , McDonald L. , Evans R. , Phillips K. , more...
      Nature441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    3. 3.
      "Recombinant analysis of human alpha 1 (XVI) collagen. Evidence for processing of the N-terminal globular domain."
      Tillet E. , Mann K. , Nischt R. , Pan T.-C. , Chu M.-L. , Timpl R.
      Eur. J. Biochem.228:160-168(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 22-33;SUBUNIT;GLYCOSYLATION
    4. 4.
      "Molecular structure and interaction of recombinant human type XVI collagen."
      Kassner A. , Tiedemann K. , Notbohm H. , Ludwig T. , Morgelin M. , Reinhardt D.P. , Chu M.-L. , Bruckner P. , Grassel S.
      J. Mol. Biol.339:835-853(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 22-30; 257-265 AND 941-950;SUBUNIT;INTERACTION WITH FBN1 AND FN1;GLYCOSYLATION
    5. 5.
      Totoki Y. , Toyoda A. , Takeda T. , Sakaki Y. , Tanaka A. , Yokoyama S. , Ohara O. , Nagase T. , Kikuno R.F.
      Submitted (2005-03) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 111-1604 (ISOFORM 2)
      tissue: Spleen.
    6. 6.
      Kimura S.
      Submitted (1989-04) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 403-849
      tissue: Placenta.
    7. 7.
      "Molecular cloning and partial characterization of a novel collagen chain, alpha 1(XVI), consisting of repetitive collagenous domains and cysteine-containing non-collagenous segments."
      Yamaguchi N. , Kimura S. , McBride O.W. , Hori H. , Yamada Y. , Kanamori T. , Yamakoshi H. , Nagai Y.
      J. Biochem.112:856-863(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 418-1604 (ISOFORM 1)
      tissue: Placenta.
    8. 8.
      "Large-scale cDNA transfection screening for genes related to cancer development and progression."
      Wan D. , Gong Y. , Qin W. , Zhang P. , Li J. , Wei L. , Zhou X. , Li H. , Qiu X. , Zhong F. , He L. , Yu J. , Yao G. , Jiang H. , Qian L. , Yu Y. , Shu H. , Chen X. , more...
      Proc. Natl. Acad. Sci. U.S.A.101:15724-15729(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1387-1604
    9. 9.
      "Biosynthesis and processing of type XVI collagen in human fibroblasts and smooth muscle cells."
      Grassel S. , Timpl R. , Tan E.M.L. , Chu M.-L.
      Eur. J. Biochem.242:576-584(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBUNIT;SUBCELLULAR LOCATION
    10. 10.
      "Discrete integration of collagen XVI into tissue-specific collagen fibrils or beaded microfibrils."
      Kassner A. , Hansen U. , Miosge N. , Reinhardt D.P. , Aigner T. , Bruckner-Tuderman L. , Bruckner P. , Grassel S.
      Matrix Biol.22:131-143(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
    11. 11.
      "Collagen XVI harbors an integrin alpha1 beta1 recognition site in its C-terminal domains."
      Eble J.A. , Kassner A. , Niland S. , Morgelin M. , Grifka J. , Grassel S.
      J. Biol. Chem.281:25745-25756(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBUNIT;INTERACTION WITH INTEGRIN ALPHA-1/BETA-1 AND INTEGRIN ALPHA-2/BETA-1
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