RBBP8 ELISA Kit for Bovine(Bos taurus) | EIAab.comRBBP8 ELISA Kit for Bovine(Bos taurus)

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RBBP8 (Gene name),

DNA endonuclease RBBP8 (Protein name ), COM1_BOVIN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

RBBP8(CTIP);

Protein name:

DNA endonuclease RBBP8;

Alternative:

Retinoblastoma-binding protein 8(RBBP-8);CtBP-interacting protein(CtIP);Sporulation in the absence of SPO11 protein 2 homolog(SAE2);Retinoblastoma-interacting protein and myosin-like(RIM);

Organism:

Bovine (Bos taurus).

General Annotation

Sub Unit:

Homodimer; dimerizes via the coiled coil domain. Interacts (via the PXDLS motif) with CTBP1. Component of the BRCA1-RBBBP8 complex. Interacts (the Ser-321 phosphorylated form) with BRCA1 (via the C-terminal BRCA1 domains): the interaction occurs in the G2 phase, ubiquitinates RBBP8 and involves RBBP8 in BRCA1-dependent G2/M checkpoint control on DNA damage. Interacts with RB1. Interacts with the MRN complex. Interacts directly with MRE11A; the interaction is required for efficient homologous recombination (HR) and regulation of the MRN complex. Interacts directly with RAD50. Interacts directly with NBN. Interacts with SIRT6; the interaction deacetylates RBBP8 upon DNA damage. Interacts with LM04 (via the LIM zinc-binding 1 domain).

Function:

Endonuclease that cooperates with the MRE11-RAD50-NBN (MRN) complex in processing meiotic and mitotic double-strand breaks (DSBs) by ensuring both resection and intrachromosomal association of the broken ends. Functions downstream of the MRN complex and ATM, promotes ATR activation and its recruitment to DSBs in the S/G2 phase facilitating the generation of ssDNA. Component of the BRCA1-RBBP8 complex that regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage. Promotes microhomology-mediated alternative end joining (A-NHEJ) during class-switch recombination and plays an essential role in chromosomal translocations.

Subcellular Location:

Nucleus Associates with sites of DNA damage in S/G2 phase. Ubiquitinated RBBP8 binds to chromatin following DNA damage.

Protein Attributes:

Sequence length:

757

Sequence:

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750:

757:

KKPNISW

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

KEGG:

bta:512977

UniGene:

Bt.16288

STRING:

9913.ENSBTAP00000008875

Pfam:

PF10482

Uniprot:

A6QNQ6

FOR

ELISA Kit for Bovine DNA endonuclease RBBP8

CLIA Kit for Bovine DNA endonuclease RBBP8

Polyclonal Antibody for Bovine DNA endonuclease RBBP8

Monoclonal Antibody for Bovine DNA endonuclease RBBP8

Protein for Bovine DNA endonuclease RBBP8

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"A whole-genome assembly of the domestic cow, Bos taurus."
Zimin A.V. , Delcher A.L. , Florea L. , Kelley D.R. , Schatz M.C. , Puiu D. , Hanrahan F. , Pertea G. , Van Tassell C.P. , Sonstegard T.S. , Marcais G. , Roberts M. , Subramanian P. , Yorke J.A. , Salzberg S.L.
Genome Biol.10:R42.01-R42.10(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
strain: Hereford.
2.

NIH - Mammalian Gene Collection (MGC) project
Submitted (2007-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain: Hereford.
tissue: Ascending colon.

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