Rbbp8 ELISA Kit for Rat(Rattus norvegicus) | EIAab.comRbbp8 ELISA Kit for Rat(Rattus norvegicus)

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Index > Protein center > Rbbp8(Gene name) > Rat

Rbbp8 (Gene name),

DNA endonuclease RBBP8 (Protein name ), COM1_RAT from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

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Gene name:

Rbbp8(Ctip);

Protein name:

DNA endonuclease RBBP8;

Alternative:

Retinoblastoma-binding protein 8(RBBP-8);CtBP-interacting protein(CtIP);Sporulation in the absence of SPO11 protein 2 homolog(SAE2);Retinoblastoma-interacting protein and myosin-like(RIM);

Organism:

Rat (Rattus norvegicus).

General Annotation

Sub Unit:

Homodimer; dimerizes via the coiled coil domain. Interacts (via the PXDLS motif) with CTBP1. Component of the BRCA1-RBBP8 complex. Interacts (the Ser-326 phosphorylated form) with BRCA1 (via the C-terminal BRCA1 domains): the interaction occurs in the G2 phase, ubiquitinates RBBP8 and involves RBBP8 in BRCA1-dependent G2/M checkpoint control on DNA damage. Interacts with RB1. Interacts with the MRN complex. Interacts directly with MRE11A; the interaction is required for efficient homologous recombination (HR) and regulation of the MRN complex. Interacts directly with RAD50. Interacts directly with NBN. Interacts with SIRT6; the interaction deacetylates RBBP8 upon DNA damage. Interacts with LM04 (via the LIM zinc-binding 1 domain).

Function:

Endonuclease that cooperates with the MRE11-RAD50-NBN (MRN) complex in processing meiotic and mitotic double-strand breaks (DSBs) by ensuring both resection and intrachromosomal association of the broken ends. Functions downstream of the MRN complex and ATM, promotes ATR activation and its recruitment to DSBs in the S/G2 phase facilitating the generation of ssDNA. Component of the BRCA1-RBBP8 complex that regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage. Promotes microhomology-mediated alternative end joining (A-NHEJ) during class-switch recombination and plays an essential role in chromosomal translocations.

Subcellular Location:

Nucleus Associates with sites of DNA damage in S/G2 phase. Ubiquitinated RBBP8 binds to chromatin following DNA damage.

Protein Attributes:

Sequence length:

893

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