Protein name:
Collagen alpha-1(XXV) chain ;
Alternative:
CLAC-P ;
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Forms homodimers and homotrimers. Binds to the fibrillized forms of beta amyloid peptide 40 (beta-APP40) and beta amyloid peptide 42 (beta-APP42). Found associated with beta-APP42 more frequently than with beta-APP40.
Function:
Inhibits fibrillization of beta amyloid peptide during the elongation phase. Has also been shown to assemble amyloid fibrils into protease-resistant aggregates. Binds heparin.
Subcellular Location:
Membrane
Single-pass type II membrane protein
After proteolytic cleavage, CLAC is secreted.
Protein Attributes:
50:
MLVKKLAGKG | GGRESGSEDP | RPLGQRCAGT | MPSCTALATL | LSVVAVAFCF |
100:
YLGVKTNDLQ | ARIVALESAK | GTPSFHPLSD | TVDELKAMVQ | EKVERLLAQK |
150:
SYEYMAKIRT | VREAPLECNC | PAGPPGKRGK | RGRRGESGPP | GQPGPQGPPG |
200:
PKGDKGEQGD | QGPRMVFPKI | NHGFLSADQQ | LIKRRLIKGD | QGQAGPPGPP |
250:
GPPGPRGPPG | DTGKDGPRGM | PGVPGEPGKP | GEQGLMGPLG | PPGQKGSIGA |
300:
PGTPGMDGQK | GEPGSPGAAG | QSGLPGPKGE | PGKEGEKGDA | GENGPKGDTG |
350:
EKGDPGSSAA | GIKGEPGESG | RPGQKGEPGL | PGLPGLPGIK | GEPGFIGPQG |
400:
EPGLPGLPGT | KGDRGEAGPP | GRGERGDPGA | PGPKGKQGES | GARGPKGSKG |
450:
DRGDKGDSGA | LGPRGPPGQK | GDPGATEIID | YNGNLHEALQ | RITTLTVTGP |
500:
PGPPGPQGLQ | GPKGEQGSPG | IPGVDGEQGL | KGSKGDMGDP | GVPGEKGGLG |
550:
LPGLPGANGV | KGEKGDTGLP | GPQGPSIIGP | PGPPGPHGPP | GPMGPHGLPG |
600:
PKGASGLDGK | PGSRGADGPI | GPHGPAGPKG | ERGEKGAMGE | PGPRGPYGLP |
650:
GKDGEPGLDG | FPGPRGEKGD | LGEKGEKGFR | GVKGEKGEPG | QPGLDGLDAP |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
ELISA Kit for Mouse Collagen alpha-1(XXV) chain
ELISA Kit for Mouse Collagen alpha-1(XXV) chain
CLIA Kit for Mouse Collagen alpha-1(XXV) chain
CLIA Kit for Mouse Collagen alpha-1(XXV) chain
Polyclonal Antibody for Mouse Collagen alpha-1(XXV) chain
Polyclonal Antibody for Mouse Collagen alpha-1(XXV) chain
Monoclonal Antibody for Mouse Collagen alpha-1(XXV) chain
Monoclonal Antibody for Mouse Collagen alpha-1(XXV) chain
Protein for Mouse Collagen alpha-1(XXV) chain
Protein for Mouse Collagen alpha-1(XXV) chain
R&D Technical Data
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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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Precision
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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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Recovery
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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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Linearity
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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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References
1.
"CLAC: a novel Alzheimer amyloid plaque component derived from a transmembrane precursor, CLAC-P/collagen type XXV."
Hashimoto T.
,
Wakabayashi T.
,
Watanabe A.
,
Kowa H.
,
Hosoda R.
,
Nakamura A.
,
Kanazawa I.
,
Arai T.
,
Takio K.
,
Mann D.M.A.
,
Iwatsubo T.
EMBO J.21:1524-1534(2002)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA];TISSUE SPECIFICITY
strain :
BALB/c .
tissue :
Brain .
2.
"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M.
,
Goodstadt L.
,
Hillier L.W.
,
Zody M.C.
,
Goldstein S.
,
She X.
,
Bult C.J.
,
Agarwala R.
,
Cherry J.L.
,
DiCuccio M.
,
Hlavina W.
,
Kapustin Y.
,
Meric P.
,
Maglott D.
,
Birtle Z.
,
Marques A.C.
,
Graves T.
,
Zhou S.
,
Teague B.
,
Potamousis K.
,
Churas C.
,
Place M.
,
Herschleb J.
,
Runnheim R.
,
Forrest D.
,
Amos-Landgraf J.
,
Schwartz D.C.
,
Cheng Z.
,
Lindblad-Toh K.
,
Eichler E.E.
,
Ponting C.P.
more...
PLoS Biol.7:E1000112-E1000112(2009)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
strain :
C57BL/6J .
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]