Copg1 ELISA Kit for Mouse(Mus musculus) | EIAab.comCopg1 ELISA Kit for Mouse(Mus musculus)

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Copg1 (Gene name),

Coatomer subunit gamma-1 (Protein name ), COPG1_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

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Gene name:

Copg1(Copg);

Protein name:

Coatomer subunit gamma-1;

Alternative:

Gamma-1-coat protein(Gamma-1-COP);

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits. Interacts with ZNF289/ARFGAP2 through its C-terminal appendage domain (By similarity). Interacts with EGFR upon EGF treatment; interaction is essential for regulation of EGF-dependent nuclear transport of EGFR by retrograde trafficking from the Golgi to the ER (By similarity). Interacts with COPB1 (By similarity). Interacts with TMED10 (via C-terminus). Interacts with TMED2, TMED3, TMED7 and TMED9.

Function:

The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity). Required for limiting lipid storage in lipid droplets. Involved in lipid homeostasis by regulating the presence of perilipin family members PLIN2 and PLIN3 at the lipid droplet surface and promoting the association of adipocyte triglyceride lipase (PNPLA2) with the lipid droplet surface to mediate lipolysis.

Subcellular Location:

Cytoplasm Cytosol Golgi apparatus membrane Peripheral membrane protein Cytoplasmic side Cytoplasmic vesicle COPI-coated vesicle membrane Peripheral membrane protein Cytoplasmic side The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it (By similarity). Predominantly located in the cis-Golgi apparatus.

Protein Attributes:

Sequence length:

874

Sequence:

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