Protein name:
Coordinator of PRMT5 and differentiation stimulator ;
Alternative:
Cooperator of PRMT5 ;
Organism:
Bovine (Bos taurus).
General Annotation
Sub Unit:
Interacts with PRMT5 (By similarity). Interacts with histone H4; specifically interacts with the N-terminus of histone H4 but not with histone H3 (By similarity). Interacts with CBFB (By similarity). Found in a complex with PRMT5, RUNX1 and CBFB.
Function:
Histone-binding protein required for histone H4 methyltransferase activity of PRMT5. Specifically required for histone H4 'Arg-3' methylation mediated by PRMT5, but not histone H3 'Arg-8' methylation, suggesting that it modulates the substrate specificity of PRMT5. Specifically interacts with the N-terminus of histone H4 but not with histone H3, suggesting that it acts by promoting the association between histone H4 and PRMT5. Involved in CCNE1 promoter repression (By similarity). Plays a role in muscle cell differentiation by modulating the recruitment of PRMT5 to the promoter of genes involved in the coordination between cell cycle exit and muscle differentiation.
Subcellular Location:
Nucleus
Protein Attributes:
50:
MDPPTAGAQS | LGAAEQPRGL | QLPSGREAPP | SPGTAFAPAD | HSSQEKATEN |
100:
ATDRLANGAQ | SIPHDSPAHG | EGTHCEEEGF | AEDDEDSDGE | PSPWELSEGM |
150:
SGCLPKEQAG | DLFHEDWDLE | LKADQGNPYD | ADDIQGCLSQ | EVRPWVCCAP |
185:
QGDMIYDPSW | HHPPPLIPHY | SKMVFETGQF | DDAED
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Bovine
Human
Mouse
ELISA Kit for Bovine Coordinator of PRMT5 and differentiation stimulator
ELISA Kit for Bovine Coordinator of PRMT5 and differentiation stimulator
ELISA Kit for Bovine Coordinator of PRMT5 and differentiation stimulator
CLIA Kit for Bovine Coordinator of PRMT5 and differentiation stimulator
CLIA Kit for Bovine Coordinator of PRMT5 and differentiation stimulator
CLIA Kit for Bovine Coordinator of PRMT5 and differentiation stimulator
Polyclonal Antibody for Bovine Coordinator of PRMT5 and differentiation stimulator
Polyclonal Antibody for Bovine Coordinator of PRMT5 and differentiation stimulator
Polyclonal Antibody for Bovine Coordinator of PRMT5 and differentiation stimulator
Monoclonal Antibody for Bovine Coordinator of PRMT5 and differentiation stimulator
Monoclonal Antibody for Bovine Coordinator of PRMT5 and differentiation stimulator
Monoclonal Antibody for Bovine Coordinator of PRMT5 and differentiation stimulator
Protein for Bovine Coordinator of PRMT5 and differentiation stimulator
Protein for Bovine Coordinator of PRMT5 and differentiation stimulator
Protein for Bovine Coordinator of PRMT5 and differentiation stimulator
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
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Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain :
Crossbred X Angus .
tissue :
Liver .