CYP2D6 ELISA Kit for Human(Homo sapiens) | EIAab.comCYP2D6 ELISA Kit for Human(Homo sapiens)

Search Protein-oriented Product center.

For antibodies, ELISA/CLIA, proteins... Product center

Tips

Index > Protein center > CYP2D6(Gene name) > Human

CYP2D6 (Gene name),

Cytochrome P450 2D6 (Protein name ), CP2D6_HUMAN from NCBI database.

top

General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

Feedback

Gene name:

CYP2D6(CYP2DL1);

Protein name:

Cytochrome P450 2D6;

Alternative:

Cytochrome P450-DB1;CYPIID6;Debrisoquine 4-hydroxylase;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

N/A

Function:

Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic antidepressants.

Subcellular Location:

Endoplasmic reticulum membrane Peripheral membrane protein Microsome membrane Peripheral membrane protein

Protein Attributes:

Sequence length:

497

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

497:

MELFLFFTSL | LQHFSFSVPT | GQPRPSHHGV | FAFLVSPSPY | ELCAVPR

3D Structure:

N/A

Predicted Eptitope:

Please Sign in.

Vaild Sequence:

Please Sign in.

Related Databases

SMR:

P10635

UniGene:

Hs.333497

MIM:

124030

STRING:

9606.ENSP00000353820

UniGene:

Hs.648256

String:

P10635

Pfam:

PF00067

KEGG:

hsa:1565

Uniprot:

P10635

FOR

ELISA Kit for Human Cytochrome P450 2D6

Cat.:

E0226h

Price:

Please sign in first.

Manual:

Looking for manual.

MSDS:

Please sign in first.

Packing:

96T

Range:

Please sign in first.

CLIA Kit for Human Cytochrome P450 2D6

Cat.:

U0226h

Price:

Please sign in first.

Manual:

Looking for manual.

MSDS:

Please sign in first.

Packing:

96T

Range:

Please sign in first.

Polyclonal Antibody for Human Cytochrome P450 2D6

Cat.:

P0226Rb-h

Price:

Please sign in first.

Packing:

40ug/0.2ml

Monoclonal Antibody for Human Cytochrome P450 2D6

Protein for Human Cytochrome P450 2D6

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Human debrisoquine 4-hydroxylase (P450IID1): cDNA and deduced amino acid sequence and assignment of the CYP2D locus to chromosome 22."
Gonzalez F.J. , Vilbois F. , Hardwick J.P. , McBride O.W. , Nebert D.W. , Gelboin H.V. , Meyer U.A.
Genomics2:174-179(1988) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
2.

"Characterization of the common genetic defect in humans deficient in debrisoquine metabolism."
Gonzalez F.J. , Skoda R.C. , Kimura S. , Umeno M. , Zanger U.M. , Nebert D.W. , Gelboin H.V. , Hardwick J.P. , Meyer U.A.
Nature331:442-446(1988) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
tissue: Liver.
3.

"The human debrisoquine 4-hydroxylase (CYP2D) locus: sequence and identification of the polymorphic CYP2D6 gene, a related gene, and a pseudogene."
Kimura S. , Umeno M. , Skoda R.C. , Meyer U.A. , Gonzalez F.J.
Am. J. Hum. Genet.45:889-904(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
4.

"Identification and characterization of novel sequence variations in the cytochrome P4502D6 (CYP2D6) gene in African Americans."
Gaedigk A. , Bhathena A. , Ndjountche L. , Pearce R.E. , Abdel-Rahman S.M. , Alander S.W. , Bradford L.D. , Rogan P.K. , Leeder J.S.
Pharmacogenomics J.5:173-182(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE CYP2D6*1);IDENTIFICATION OF ALLELES CYP2D6*41B; CYP2D6*45A; CYP2D6*45B AND CYP2D6*46;VARIANTS HIS-26; LYS-155; CYS-296 AND THR-486;CHARACTERIZATION OF ISOZYMES CYP2D6.45 AND CYP2D6.46
5.

Gaedigk A. , Bhathena A. , Ndjountche L. , Pearce R.E. , Abdel-Rahman S.M. , Alander S.W. , Bradford L.D. , Rogan P.K. , Leeder J.S.
Pharmacogenomics J.5:276-276(2005)

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ERRATUM
6.

"CYP2D6 evolution and allele diversity among human races."
Koch W.H. , Nikoloff D.M. , Lu W. , Pan R.M. , deLeon J. , Wedlund P.J.
Submitted (2005-11) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANT HIS-26
7.

"The DNA sequence of human chromosome 22."
Dunham I. , Hunt A.R. , Collins J.E. , Bruskiewich R. , Beare D.M. , Clamp M. , Smink L.J. , Ainscough R. , Almeida J.P. , Babbage A.K. , Bagguley C. , Bailey J. , Barlow K.F. , Bates K.N. , Beasley O.P. , Bird C.P. , Blakey S.E. , Bridgeman A.M. , more...
Nature402:489-495(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA];VARIANTS CYS-296 AND THR-486
8.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2);VARIANTS CYS-296 AND THR-486
9.

"Crystal structure of human cytochrome P450 2D6."
Rowland P. , Blaney F.E. , Smyth M.G. , Jones J.J. , Leydon V.R. , Oxbrow A.K. , Lewis C.J. , Tennant M.G. , Modi S. , Eggleston D.S. , Chenery R.J. , Bridges A.M.
J. Biol. Chem.281:7614-7622(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF 34-497 IN COMPLEX WITH HEME;FUNCTION
10.

"Identification of a new variant CYP2D6 allele lacking the codon encoding Lys-281: possible association with the poor metabolizer phenotype."
Tyndale R. , Aoyama T. , Broly F. , Matsunaga T. , Inaba T. , Kalow W. , Gelboin H.V. , Meyer U.A. , Gonzalez F.J.
Pharmacogenetics1:26-32(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT CYP2D6*9 LYS-281 DEL
11.

"Evidence for a new variant CYP2D6 allele CYP2D6J in a Japanese population associated with lower in vivo rates of sparteine metabolism."
Yokota H. , Tamura S. , Furuya H. , Kimura S. , Watanabe M. , Kanazawa I. , Kondo I. , Gonzalez F.J.
Pharmacogenetics3:256-263(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS CYP2D6*10 SER-34 AND THR-486
12.

"A missense mutation in exon 6 of the CYP2D6 gene leading to a histidine 324 to proline exchange is associated with the poor metabolizer phenotype of sparteine."
Evert B. , Griese E.U. , Eichelbaum M.
Naunyn Schmiedebergs Arch. Pharmacol.350:434-439(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT CYP2D6*7 PRO-324
13.

"An inactive cytochrome P450 CYP2D6 allele containing a deletion and a base substitution."
Daly A.K. , Leathart J.B. , London S.J. , Idle J.R.
Hum. Genet.95:337-341(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT CYP2D6*6B/6C GLU-212
14.

"A novel mutant variant of the CYP2D6 gene (CYP2D6*17) common in a black African population: association with diminished debrisoquine hydroxylase activity."
Masimirembwa C. , Persson I. , Bertilsson L. , Hasler J. , Ingelman-Sundberg M.
Br. J. Clin. Pharmacol.42:713-719(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT CYP2D6*17 ILE-107
15.

"An additional allelic variant of the CYP2D6 gene causing impaired metabolism of sparteine."
Marez D. , Legrand M. , Sabbagh N. , Lo-Guidice J.-M. , Boone P. , Broly F.
Hum. Genet.97:668-670(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT CYP2D6*12 ARG-42
16.

"Polymorphism of the cytochrome P450 CYP2D6 gene in a European population: characterization of 48 mutations and 53 alleles, their frequencies and evolution."
Marez D. , Legrand M. , Sabbagh N. , Guidice J.M. , Spire C. , Lafitte J.J. , Meyer U.A. , Broly F.
Pharmacogenetics7:193-202(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS
17.

"G169R mutation diminishes the metabolic activity of CYP2D6 in Chinese."
Wang S.L. , Lai M.D. , Huang J.D.
Drug Metab. Dispos.27:385-388(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT CYP2D6*14 ARG-169
18.

"Genetic variation in eleven phase I drug metabolism genes in an ethnically diverse population."
Solus J.F. , Arietta B.J. , Harris J.R. , Sexton D.P. , Steward J.Q. , McMunn C. , Ihrie P. , Mehall J.M. , Edwards T.L. , Dawson E.P.
Pharmacogenomics5:895-931(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS MET-11; HIS-26; SER-34; MET-91; ARG-94; ILE-107; ILE-120; LYS-155; SER-237; CYS-296; LYS-418; ALA-469; TYR-478 AND THR-486

Product Feedback Wall

* Email:
*Comments: