Cpeb1 ELISA Kit for Rat(Rattus norvegicus) | EIAab.comCpeb1 ELISA Kit for Rat(Rattus norvegicus)

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Cpeb1 (Gene name),

Cytoplasmic polyadenylation element-binding protein 1 (Protein name ), CPEB1_RAT from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

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Gene name:

Cpeb1;

Protein name:

Cytoplasmic polyadenylation element-binding protein 1(CPE-BP1;CPE-binding protein 1;CPEB;CPEB-1);

Alternative:

Organism:

Rat (Rattus norvegicus).

General Annotation

Sub Unit:

Interacts with kinesin, dynein, APLP1, APLP2, PAPD4/GLD2 and APP. Both phosphorylated and non phosphorylated forms interact with APLP1.

Function:

Sequence-specific RNA-binding protein that regulates mRNA cytoplasmic polyadenylation and translation initiation during oocyte maturation, early development and at postsynapse sites of neurons. Binds to the cytoplasmic polyadenylation element (CPE), an uridine-rich sequence element (consensus sequence 5'-UUUUUAU-3') within the 3'-UTR of mRNAs. In absence of phosphorylation and in association with TACC3 is also involved as a repressor of translation of CPE-containing mRNA; a repression that is relieved by phosphorylation or degradation. Involved in the transport of CPE-containing mRNA to dendrites; those mRNAs may be transported to dendrites in a translationally dormant form and translationally activated at synapses. Its interaction with APLP1 promotes local CPE-containing mRNA polyadenylation and translation activation. Induces the assembly of stress granules in the absence of stress.

Subcellular Location:

Cytoplasm Cell junction synapse Cytoplasm P-body Cytoplasmic granule Membrane Cell junction synapse postsynaptic cell membrane postsynaptic density Localizes in synaptosomes at dendritic synapses of neurons. Strongly enriched in postsynaptic density fractions. Transported into dendrites in a microtubule-dependent fashion and colocalizes in mRNA-containing particles with TACC3, dynein and kinesin (By similarity). Membrane-associated (By similarity). Colocalizes at excitatory synapses with members of the polyadenylation and translation complex factors (CPSF, APLP1, TACC3, AURKA, SYP, etc.) including CPE-containing RNAs (By similarity). In P-bodies and stress granules (By similarity). Recruited to stress granules (SGs) upon arsenite treatment.

Protein Attributes:

Sequence length:

561

Sequence:

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