Gene name:
Creb3l1 (Oasis) ;
Protein name:
Cyclic AMP-responsive element-binding protein 3-like protein 1 (cAMP-responsive element-binding protein 3-like protein 1) ;
Alternative:
Old astrocyte specifically-induced substance (OASIS) ;
Organism:
Mouse (Mus musculus).
General Annotation
Function:
Transcription factor that acts during endoplasmic reticulum stress by activating unfolded protein response target genes. Specifically involved in ER-stress response in astrocytes in the central nervous system. May play a role in gliosis. In vitro, binds to box-B element, cAMP response element (CRE) and CRE-like sequences, and activates transcription through box-B element but not through CRE.
Subcellular Location:
Processed cyclic AMP-responsive element-binding protein 3-like protein 1
Nucleus
Under ER stress the cleaved N-terminal cytoplasmic domain translocates into the nucleus.
Protein Attributes:
50:
MDAVLEPFPA | DRLFPGSSFL | DLGDLNESDF | LNNAHFPEHL | DHFVENMEDF |
100:
SNDLFSSFFD | DPVLDEKSAL | LDMELDSPAP | GIQAEHSYSL | SGDSAPQSPL |
150:
VPVKMEDTTQ | DVEHGAWALG | NKLCSIMVKQ | EQSPELPVDP | LAASSAMAAA |
200:
AAMATPPLLG | LSPMPRLPIP | HQAPGEMTQL | PVIKAEPPEM | SQFLKVTPED |
250:
LVQMPPTPPS | SHGSDSDGSQ | SPRSLPPSSP | VRPMARSSTA | ISTSPLLTAP |
300:
HKLQGTSGPL | LLTEEEKRTL | IAEGYPIPTK | LPLTKAEEKA | LKRVRRKIKN |
350:
KISAQESRRK | KKEYVECLEK | KVETYTSENN | ELWKKVETLE | TANRTLLQQL |
400:
QKLQTLVTSK | ISRPYKMAAT | QTGTCLMVAA | LCFVLVLGSL | VPCLPAFSSG |
450:
SMTVKEDPIA | ADSVYAASQM | PSRSLLFYDD | GAGSWEDGRG | ALLPVEPPEG |
500:
WELKPGGPAE | QRPQDHLRHD | RADSIHETTK | YLRETWPEDT | DDNGTSPNFS |
519:
HPEWFHDRDL | GPNTTIKLS
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Rat
Human
Mouse
ELISA Kit for Mouse cAMP-responsive element-binding protein 3-like protein 1
ELISA Kit for Mouse cAMP-responsive element-binding protein 3-like protein 1
ELISA Kit for Mouse cAMP-responsive element-binding protein 3-like protein 1
CLIA Kit for Mouse cAMP-responsive element-binding protein 3-like protein 1
CLIA Kit for Mouse cAMP-responsive element-binding protein 3-like protein 1
CLIA Kit for Mouse cAMP-responsive element-binding protein 3-like protein 1
Polyclonal Antibody for Mouse cAMP-responsive element-binding protein 3-like protein 1
Polyclonal Antibody for Mouse cAMP-responsive element-binding protein 3-like protein 1
Polyclonal Antibody for Mouse cAMP-responsive element-binding protein 3-like protein 1
Monoclonal Antibody for Mouse cAMP-responsive element-binding protein 3-like protein 1
Monoclonal Antibody for Mouse cAMP-responsive element-binding protein 3-like protein 1
Monoclonal Antibody for Mouse cAMP-responsive element-binding protein 3-like protein 1
Protein for Mouse cAMP-responsive element-binding protein 3-like protein 1
Protein for Mouse cAMP-responsive element-binding protein 3-like protein 1
Protein for Mouse cAMP-responsive element-binding protein 3-like protein 1
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
"Identification of a novel gene, OASIS, which encodes for a putative CREB/ATF family transcription factor in the long-term cultured astrocytes and gliotic tissue."
Honma Y.
,
Kanazawa K.
,
Mori T.
,
Tanno Y.
,
Tojo M.
,
Kiyosawa H.
,
Takeda J.
,
Nikaido T.
,
Tsukamoto T.
,
Yokoya S.
,
Wanaka A.
Brain Res. Mol. Brain Res.69:93-103(1999)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);TISSUE SPECIFICITY;DEVELOPMENTAL STAGE;INDUCTION
strain :
ICR .
2.
"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M.
,
Goodstadt L.
,
Hillier L.W.
,
Zody M.C.
,
Goldstein S.
,
She X.
,
Bult C.J.
,
Agarwala R.
,
Cherry J.L.
,
DiCuccio M.
,
Hlavina W.
,
Kapustin Y.
,
Meric P.
,
Maglott D.
,
Birtle Z.
,
Marques A.C.
,
Graves T.
,
Zhou S.
,
Teague B.
,
Potamousis K.
,
Churas C.
,
Place M.
,
Herschleb J.
,
Runnheim R.
,
Forrest D.
,
Amos-Landgraf J.
,
Schwartz D.C.
,
Cheng Z.
,
Lindblad-Toh K.
,
Eichler E.E.
,
Ponting C.P.
more...
PLoS Biol.7:E1000112-E1000112(2009)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
strain :
C57BL/6J .
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
strain :
FVB/N .
tissue :
Salivary gland .
4.
"Expression of OASIS, a CREB/ATF family transcription factor, in CNS lesion and its transcriptional activity."
Nikaido T.
,
Iseki K.
,
Mori T.
,
Takaki H.
,
Yokoya S.
,
Hagino S.
,
Takeda J.
,
Zhang Y.
,
Takeuchi M.
,
Kikuchi S.
,
Wanaka A.
Brain Res. Mol. Brain Res.108:129-138(2002)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;INDUCTION
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : DEVELOPMENTAL STAGE
6.
"OASIS, a CREB/ATF-family member, modulates UPR signalling in astrocytes."
Kondo S.
,
Murakami T.
,
Tatsumi K.
,
Ogata M.
,
Kanemoto S.
,
Otori K.
,
Iseki K.
,
Wanaka A.
,
Imaizumi K.
Nat. Cell Biol.7:186-194(2005)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;SUBCELLULAR LOCATION