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Index > Protein center > CSDE1(Gene name) > Human
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  • CSDE1 (Gene name),
  • Cold shock domain-containing protein E1 (Protein name ),  CSDE1_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    CSDE1(D1S155E;KIAA0885;NRU;UNR);
    Protein name:
    Cold shock domain-containing protein E1;
    Alternative:
    Protein UNR;N-ras upstream gene protein;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Component of a multi subunit autoregulatory ribonucleoprotein complex (ARC), at least composed of IGF2BP1, PABPC1 and CSDE1. Interacts with STRAP. Part of a complex associated with the FOS mCRD domain and consisting of PABPC1, PAIP1, HNRPD and SYNCRIP. The interaction with PABPC1 is direct and RNA-independent.
    Function:
    RNA-binding protein. Required for internal initiation of translation of human rhinovirus RNA. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain.
    Subcellular Location:
    Cytoplasm
    Protein Attributes:
    Sequence length:
    798
    Sequence:
    50:
    MSFDPNLLHN | NGHNGYPNGT | SAALRETGVI | EKLLTSYGFI | QCSERQARLF | 
    100:
    FHCSQYNGNL | QDLKVGDDVE | FEVSSDRRTG | KPIAVKLVKI | KQEILPEERM | 
    150:
    NGQVVCAVPH | NLESKSPAAP | GQSPTGSVCY | ERNGEVFYLT | YTPEDVEGNV | 
    200:
    QLETGDKINF | VIDNNKHTGA | VSARNIMLLK | KKQARCQGVV | CAMKEAFGFI | 
    250:
    ERGDVVKEIF | FHYSEFKGDL | ETLQPGDDVE | FTIKDRNGKE | VATDVRLLPQ | 
    300:
    GTVIFEDISI | EHFEGTVTKV | IPKVPSKNQN | DPLPGRIKVD | FVIPKELPFG | 
    350:
    DKDTKSKVTL | LEGDHVRFNI | STDRRDKLER | ATNIEVLSNT | FQFTNEAREM | 
    400:
    GVIAAMRDGF | GFIKCVDRDV | RMFFHFSEIL | DGNQLHIADE | VEFTVVPDML | 
    450:
    SAQRNHAIRI | KKLPKGTVSF | HSHSDHRFLG | TVEKEATFSN | PKTTSPNKGK | 
    500:
    EKEAEDGIIA | YDDCGVKLTI | AFQAKDVEGS | TSPQIGDKVE | FSISDKQRPG | 
    550:
    QQVATCVRLL | GRNSNSKRLL | GYVATLKDNF | GFIETANHDK | EIFFHYSEFS | 
    600:
    GDVDSLELGD | MVEYSLSKGK | GNKVSAEKVN | KTHSVNGITE | EADPTIYSGK | 
    650:
    VIRPLRSVDP | TQTEYQGMIE | IVEEGDMKGE | VYPFGIVGMA | NKGDCLQKGE | 
    700:
    SVKFQLCVLG | QNAQTMAYNI | TPLRRATVEC | VKDQFGFINY | EVGDSKKLFF | 
    750:
    HVKEVQDGIE | LQAGDEVEFS | VILNQRTGKC | SACNVWRVCE | GPKAVAAPRP | 
    798:
    DRLVNRLKNI | TLDDASAPRL | MVLRQPRGPD | NSMGFGAERK | IRQAGVID
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    MIM:
    SMR:
    UniGene:
    Pfam:
    String:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Human Cold shock domain-containing protein E1
    ELISA Kit for Human Cold shock domain-containing protein E1
    ELISA Kit for Human Cold shock domain-containing protein E1
    CLIA Kit for Human Cold shock domain-containing protein E1
    CLIA Kit for Human Cold shock domain-containing protein E1
    CLIA Kit for Human Cold shock domain-containing protein E1
    Polyclonal Antibody for Human Cold shock domain-containing protein E1
    Polyclonal Antibody for Human Cold shock domain-containing protein E1
    Polyclonal Antibody for Human Cold shock domain-containing protein E1
    Monoclonal Antibody for Human Cold shock domain-containing protein E1
    Monoclonal Antibody for Human Cold shock domain-containing protein E1
    Monoclonal Antibody for Human Cold shock domain-containing protein E1
    Protein for Human Cold shock domain-containing protein E1
    Protein for Human Cold shock domain-containing protein E1
    Protein for Human Cold shock domain-containing protein E1

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Organization of the human N-ras locus: characterization of a gene located immediately upstream of N-ras."
      Nicolaiew N. , Triqueneaux G. , Dautry F.
      Oncogene6:721-730(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
    2. 2.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
      tissue: Pituitary.
    3. 3.
      "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T. , Ishikawa K. , Suyama M. , Kikuno R. , Hirosawa M. , Miyajima N. , Tanaka A. , Kotani H. , Nomura N. , Ohara O.
      DNA Res.5:355-364(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Brain.
    4. 4.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Thalamus.
    5. 5.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3)
      tissue: Liver.
    6. 6.
      "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G. , Barlow K.F. , McLay K.E. , Kaul R. , Swarbreck D. , Dunham A. , Scott C.E. , Howe K.L. , Woodfine K. , Spencer C.C.A. , Jones M.C. , Gillson C. , Searle S. , Zhou Y. , Kokocinski F. , McDonald L. , Evans R. , Phillips K. , more...
      Nature441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    7. 7.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    8. 8.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
      tissue: Cervix.
    9. 9.
      Yu W. , Gibbs R.A.
      Submitted (1998-06) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-498 (ISOFORM 2)
      tissue: Brain.
    10. 10.
      "Exon skipping in the expression of the gene immediately upstream of N-ras (unr/NRU)."
      Boussadia O. , Jacquemin-Sablon H. , Dautry F.
      Biochim. Biophys. Acta1172:64-72(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 67-166;ALTERNATIVE SPLICING
    11. 11.
      "unr, a cellular cytoplasmic RNA-binding protein with five cold-shock domains, is required for internal initiation of translation of human rhinovirus RNA."
      Hunt S.L. , Hsuan J.J. , Totty N. , Jackson R.J.
      Genes Dev.13:437-448(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH STRAP
    12. 12.
      "A mechanism for translationally coupled mRNA turnover: interaction between the poly(A) tail and a c-fos RNA coding determinant via a protein complex."
      Grosset C. , Chen C.-Y.A. , Xu N. , Sonenberg N. , Jacquemin-Sablon H. , Shyu A.-B.
      Cell103:29-40(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN TRANSLATIONALLY COUPLED MRNA TURNOVER;IDENTIFICATION IN A COMPLEX WITH HNRPD; SYNCRIP; PABPC1 AND PAIP1
    13. 13.
      "UNR, a new partner of poly(A)-binding protein, plays a key role in translationally coupled mRNA turnover mediated by the c-fos major coding-region determinant."
      Chang T.-C. , Yamashita A. , Chen C.-Y.A. , Yamashita Y. , Zhu W. , Durdan S. , Kahvejian A. , Sonenberg N. , Shyu A.-B.
      Genes Dev.18:2010-2023(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH PABPC1
    14. 14.
      "The autoregulatory translational control element of poly(A)-binding protein mRNA forms a heteromeric ribonucleoprotein complex."
      Patel G.P. , Ma S. , Bag J.
      Nucleic Acids Res.33:7074-7089(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION IN A MRNP COMPLEX WITH IGF2BP1 AND PABPC1
    15. 15.
      "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V. , Blagoev B. , Gnad F. , Macek B. , Kumar C. , Mortensen P. , Mann M.
      Cell127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    16. 16.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-123;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    17. 17.
      "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S. , Helbig A.O. , Slijper M. , Krijgsveld J. , Heck A.J. , Mohammed S.
      Anal. Chem.81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    18. 18.
      "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C. , Kumar C. , Gnad F. , Nielsen M.L. , Rehman M. , Walther T.C. , Olsen J.V. , Mann M.
      Science325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-81;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    19. 19.
      "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
      Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-514;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    20. 20.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    21. 21.
      "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T. , Prokhorova T.A. , Akimov V. , Henningsen J. , Johansen P.T. , Kratchmarova I. , Kassem M. , Mann M. , Olsen J.V. , Blagoev B.
      Sci. Signal.4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-514;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    22. 22.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    23. 23.
      "The NMR solution structures of the five constituent cold-shock domains (CSD) of the human UNR (upstream of N-ras) protein."
      Goroncy A.K. , Koshiba S. , Tochio N. , Tomizawa T. , Inoue M. , Watanabe S. , Harada T. , Tanaka A. , Ohara O. , Kigawa T. , Yokoyama S.
      J. Struct. Funct. Genomics11:181-188(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 15-90; 175-259; 348-424; 508-582 AND 673-738
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