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Index > Protein center > Gps1(Gene name) > Mouse
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  • Gps1 (Gene name),
  • COP9 signalosome complex subunit 1 (Protein name ),  CSN1_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Gene name:
    Gps1(Cops1;Csn1);
    Protein name:
    COP9 signalosome complex subunit 1(SGN1;Signalosome subunit 1);
    Alternative:
    JAB1-containing signalosome subunit 1;G protein pathway suppressor 1(GPS-1);
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Component of the CSN complex, composed of COPS1/GPS1, COPS2, COPS3, COPS4, COPS5, COP6, COPS7 (COPS7A or COPS7B) and COPS8. In the complex, it probably interacts directly with COPS2, COPS3, COPS4 and CSN5. Interacts directly with inositol kinase ITPK1 (By similarity). Interacts with CAPN8.
    Function:
    Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Suppresses G-protein-and mitogen-activated protein kinase-mediated signal transduction.
    Subcellular Location:
    Cytoplasm Nucleus
    Protein Attributes:
    Sequence length:
    471
    Sequence:
    50:
    MQIDVDPQED | PQNAPDVNYV | VENPTLDLEQ | YAASYSGLMR | IERLQFIADR | 
    100:
    CPPLRVEALK | MALSFVQRTF | NVDMYEEIHR | KLSEATRELQ | NAPDAIPESG | 
    150:
    VEPPPLDTAW | VEATRKKALL | KLEKLDTDLK | NYKGNSIKES | IRRGHDDLGD | 
    200:
    HYLDCGDLSN | ALKCYSRARD | YCTSAKHVIN | MCLNVIKVSV | YLQNWSHVLS | 
    250:
    YVSKAESTPE | IAEQRGERDS | QTQAILTKLK | CAAGLAELAA | RKYKQAAKCF | 
    300:
    LLASFDHCDF | PELLSPSNVA | VYGGLCALAT | FDRQELQRNV | ISSSSFKLFL | 
    350:
    ELEPQVRDII | FKFYESKYAS | CLKMLDEMKD | NLLLDMYLAP | HVRTLYTQIR | 
    400:
    NRALIQYFSP | YVSADMHKMA | AAFNTTVAAL | EDELTQLILE | GLINARIDSH | 
    450:
    SKILYARDVD | QRSTTFEKSL | LMGKEFQRRA | KAMILRAAVL | RNQIHVKSPP | 
    471:
    REGSQGELTP | ANSQSRMSTN | M
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    Pfam:
    SMR:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse SGN1
    Cat.:
    E13953h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Mouse SGN1
    Cat.:
    E13953m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Mouse SGN1
    Cat.:
    E13953r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse SGN1
    Cat.:
    U13953h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse SGN1
    Cat.:
    U13953m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse SGN1
    Cat.:
    U13953r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Mouse SGN1
    Cat.:
    P13953Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse SGN1
    Cat.:
    P13953Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse SGN1
    Cat.:
    P13953Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Mouse SGN1
    Monoclonal Antibody for Mouse SGN1
    Monoclonal Antibody for Mouse SGN1
    Protein for Mouse SGN1
    Protein for Mouse SGN1
    Protein for Mouse SGN1

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    Linearity
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    References
    1. 1.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
      strain: NOD.
      tissue: Thymus.
    2. 2.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
      strain: C57BL/6J.
    3. 3.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Mammary tumor.
    4. 4.
      "The COP9 complex is conserved between plants and mammals and is related to the 26S proteasome regulatory complex."
      Wei N. , Tsuge T. , Serino G. , Dohmae N. , Takio K. , Matsui M. , Deng X.-W.
      Curr. Biol.8:919-922(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION IN THE CSN COMPLEX
      strain: C57BL/6.
    5. 5.
      "Stomach-specific calpain, nCL-2, localizes in mucus cells and proteolyzes the beta-subunit of coatomer complex, beta-COP."
      Hata S. , Koyama S. , Kawahara H. , Doi N. , Maeda T. , Toyama-Sorimachi N. , Abe K. , Suzuki K. , Sorimachi H.
      J. Biol. Chem.281:11214-11224(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CAPN8;DOMAIN;TISSUE SPECIFICITY
    6. 6.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-454; THR-459 AND SER-463;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Liver.
    7. 7.
      "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."
      Matsuoka S. , Ballif B.A. , Smogorzewska A. , McDonald E.R. III , Hurov K.E. , Luo J. , Bakalarski C.E. , Zhao Z. , Solimini N. , Lerenthal Y. , Shiloh Y. , Gygi S.P. , Elledge S.J.
      Science316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-459;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Embryonic fibroblast.
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