Gene name:
Gps1 (Cops1;Csn1) ;
Protein name:
COP9 signalosome complex subunit 1 (SGN1;Signalosome subunit 1) ;
Alternative:
JAB1-containing signalosome subunit 1 ;G protein pathway suppressor 1 (GPS-1) ;
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Component of the CSN complex, composed of COPS1/GPS1, COPS2, COPS3, COPS4, COPS5, COP6, COPS7 (COPS7A or COPS7B) and COPS8. In the complex, it probably interacts directly with COPS2, COPS3, COPS4 and CSN5. Interacts directly with inositol kinase ITPK1 (By similarity). Interacts with CAPN8.
Function:
Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Suppresses G-protein-and mitogen-activated protein kinase-mediated signal transduction.
Subcellular Location:
Cytoplasm
Nucleus
Protein Attributes:
50:
MQIDVDPQED | PQNAPDVNYV | VENPTLDLEQ | YAASYSGLMR | IERLQFIADR |
100:
CPPLRVEALK | MALSFVQRTF | NVDMYEEIHR | KLSEATRELQ | NAPDAIPESG |
150:
VEPPPLDTAW | VEATRKKALL | KLEKLDTDLK | NYKGNSIKES | IRRGHDDLGD |
200:
HYLDCGDLSN | ALKCYSRARD | YCTSAKHVIN | MCLNVIKVSV | YLQNWSHVLS |
250:
YVSKAESTPE | IAEQRGERDS | QTQAILTKLK | CAAGLAELAA | RKYKQAAKCF |
300:
LLASFDHCDF | PELLSPSNVA | VYGGLCALAT | FDRQELQRNV | ISSSSFKLFL |
350:
ELEPQVRDII | FKFYESKYAS | CLKMLDEMKD | NLLLDMYLAP | HVRTLYTQIR |
400:
NRALIQYFSP | YVSADMHKMA | AAFNTTVAAL | EDELTQLILE | GLINARIDSH |
450:
SKILYARDVD | QRSTTFEKSL | LMGKEFQRRA | KAMILRAAVL | RNQIHVKSPP |
471:
REGSQGELTP | ANSQSRMSTN | M
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
Rat
Polyclonal Antibody for Mouse SGN1
Polyclonal Antibody for Mouse SGN1
Polyclonal Antibody for Mouse SGN1
Monoclonal Antibody for Mouse SGN1
Monoclonal Antibody for Mouse SGN1
Monoclonal Antibody for Mouse SGN1
R&D Technical Data
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Precision
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Recovery
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Linearity
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Science309:1559-1563(2005)
[
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[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
strain :
NOD .
tissue :
Thymus .
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PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
strain :
C57BL/6J .
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue :
Mammary tumor .
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION IN THE CSN COMPLEX
strain :
C57BL/6 .
5.
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-454; THR-459 AND SER-463;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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Liver .
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Science316:1160-1166(2007)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-459;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Embryonic fibroblast .