Cops3 ELISA Kit for Mouse(Mus musculus) | EIAab.comCops3 ELISA Kit for Mouse(Mus musculus)

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Cops3 (Gene name),

COP9 signalosome complex subunit 3 (Protein name ), CSN3_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Cops3(Csn3);

Protein name:

COP9 signalosome complex subunit 3(SGN3;Signalosome subunit 3);

Alternative:

JAB1-containing signalosome subunit 3;

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Component of the CSN complex, composed of COPS1/GPS1, COPS2, COPS3, COPS4, COPS5, COP6, COPS7 (COPS7A or COPS7B) and COPS8. In the complex, it probably interacts directly with COPS1, COPS4 and COPS8. Interacts with CK2 and PKD. Interacts with the translation initiation factor EIF3S6 and IKBKG.

Function:

Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Essential to maintain the survival of epiblast cells and thus the development of the postimplantation embryo.

Subcellular Location:

Cytoplasm Nucleus

Protein Attributes:

Sequence length:

423

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

423:

PQFVQKSMGS | QEDDSGNKPS | SYS

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

Mm.40

KEGG:

mmu:26572

Pfam:

PF01399

String:

O88543

SMR:

O88543

Uniprot:

O88543

FOR

ELISA Kit for Mouse SGN3

CLIA Kit for Mouse SGN3

Polyclonal Antibody for Mouse SGN3

Monoclonal Antibody for Mouse SGN3

Protein for Mouse SGN3

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"The COP9 complex is conserved between plants and mammals and is related to the 26S proteasome regulatory complex."
Wei N. , Tsuge T. , Serino G. , Dohmae N. , Takio K. , Matsui M. , Deng X.-W.
Curr. Biol.8:919-922(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];IDENTIFICATION IN THE CSN COMPLEX
strain: C57BL/6.
2.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain: C57BL/6.
tissue: Brain.
3.

"COP9 signalosome subunit 3 is essential for maintenance of cell proliferation in the mouse embryonic epiblast."
Yan J. , Walz K. , Nakamura H. , Carattini-Rivera S. , Zhao Q. , Vogel H. , Wei N. , Justice M.J. , Bradley A. , Lupski J.R.
Mol. Cell. Biol.23:6798-6808(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;TISSUE SPECIFICITY;DISRUPTION PHENOTYPE

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