Protein name:
COP9 signalosome complex subunit 4 (SGN4;Signalosome subunit 4) ;
Alternative:
Organism:
Bovine (Bos taurus).
General Annotation
Sub Unit:
Component of the CSN complex, composed of COPS1/GPS1, COPS2, COPS3, COPS4, COPS5, COP6, COPS7 (COPS7A or COPS7B) and COPS8. In the complex, it probably interacts directly with COPS1, COPS2, COPS3, COPS5, COPS6, COPS7 (COPS7A or COPS7B) and COPS8.
Function:
Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.
Subcellular Location:
Cytoplasm
Nucleus
Protein Attributes:
50:
MAAAVRQDLA | QLMNSSGSHK | DLAGKYRQIL | EKAIQLSGAE | QLEALKAFVE |
100:
SMVNENVSLV | ISRQLLTDFC | THLPNLPDST | AKEIYHFTLE | KIQPRVISFE |
150:
EQVASIRQHL | ASIYEKEEDW | RNAAQVLVGI | PLETGQKQYN | VDYKLETYLK |
200:
IARLYLEDDD | PVQAEAYINR | ASLLQNESTN | EQLQIHYKVC | YARVLDYRRK |
250:
FIEAAQRYNE | LSYKTIVHES | ERLEALKHAL | HCTILASAGQ | QRSRMLATLF |
300:
KDERCQQLAA | YGILEKMYLD | RIIRGNQLQE | FAAMLMPHQK | ATTADGSSIL |
350:
DRAVIEHNLL | SASKLYNNIT | FEELGALLEI | PAAKAEKIAS | QMITEGRMNG |
400:
FIDQIDGIVH | FETREALPTW | DKQIQSLCFQ | VNNLLEKISQ | TAPEWTAQAM |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Rat
Pig
Mouse
Bovine
ELISA Kit for Bovine SGN4
ELISA Kit for Bovine SGN4
ELISA Kit for Bovine SGN4
ELISA Kit for Bovine SGN4
ELISA Kit for Bovine SGN4
Polyclonal Antibody for Bovine SGN4
Polyclonal Antibody for Bovine SGN4
Polyclonal Antibody for Bovine SGN4
Polyclonal Antibody for Bovine SGN4
Polyclonal Antibody for Bovine SGN4
Monoclonal Antibody for Bovine SGN4
Monoclonal Antibody for Bovine SGN4
Monoclonal Antibody for Bovine SGN4
Monoclonal Antibody for Bovine SGN4
Monoclonal Antibody for Bovine SGN4
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
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Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain :
Crossbred X Angus .
tissue :
Ileum .