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Index > Protein center > Cops4(Gene name) > Mouse
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  • Cops4 (Gene name),
  • COP9 signalosome complex subunit 4 (Protein name ),  CSN4_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    Cops4(Csn4);
    Protein name:
    COP9 signalosome complex subunit 4(SGN4;Signalosome subunit 4);
    Alternative:
    JAB1-containing signalosome subunit 4;
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Component of the CSN complex, composed of COPS1/GPS1, COPS2, COPS3, COPS4, COPS5, COP6, COPS7 (COPS7A or COPS7B) and COPS8. In the complex, it probably interacts directly with COPS1, COPS2, COPS3, COPS5, COPS6, COPS7 (COPS7A or COPS7B) and COPS8.
    Function:
    Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.
    Subcellular Location:
    Cytoplasm Nucleus
    Protein Attributes:
    Sequence length:
    406
    Sequence:
    50:
    MAAAVRQDLA | QLMNSSGSHK | DLAGKYRQIL | EKAIQLSGTE | QLEALKAFVE | 
    100:
    AMVNENVSLV | ISRQLLTDFC | THLPNLPDST | AKEVYHFTLE | KIQPRVISFE | 
    150:
    EQVASIRQHL | ASIYEKEEDW | RNAAQVLVGI | PLETGQKQYN | VDYKLETYLK | 
    200:
    IARLYLEDDD | PVQAEAYINR | ASLLQNESTN | EQLQIHYKVC | YARVLDYRRK | 
    250:
    FIEAAQRYNE | LSYKTIVHES | ERLEALKHAL | HCTILASAGQ | QRSRMLATLF | 
    300:
    KDERCQQLAA | YGILEKMYLD | RIIRGNQLQE | FAAMLMPHQK | ATTADGSSIL | 
    350:
    DRAVIEHNLL | SASKLYNNIT | FEELGALLEI | PAAKAEKIAS | QMITEGRMNG | 
    400:
    FIDQIDGIVH | FETREALPTW | DKQIQSLCFQ | VNNLLEKISQ | TAPEWTAQAM | 
    406:
    EAQMAQ
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    KEGG:
    Pfam:
    String:
    SMR:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse SGN4
    ELISA Kit for Mouse SGN4
    ELISA Kit for Mouse SGN4
    ELISA Kit for Mouse SGN4
    ELISA Kit for Mouse SGN4
    CLIA Kit for Mouse SGN4
    CLIA Kit for Mouse SGN4
    CLIA Kit for Mouse SGN4
    CLIA Kit for Mouse SGN4
    CLIA Kit for Mouse SGN4
    Polyclonal Antibody for Mouse SGN4
    Polyclonal Antibody for Mouse SGN4
    Polyclonal Antibody for Mouse SGN4
    Polyclonal Antibody for Mouse SGN4
    Polyclonal Antibody for Mouse SGN4
    Monoclonal Antibody for Mouse SGN4
    Monoclonal Antibody for Mouse SGN4
    Monoclonal Antibody for Mouse SGN4
    Monoclonal Antibody for Mouse SGN4
    Monoclonal Antibody for Mouse SGN4
    Protein for Mouse SGN4
    Protein for Mouse SGN4
    Protein for Mouse SGN4
    Protein for Mouse SGN4
    Protein for Mouse SGN4

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "The COP9 complex is conserved between plants and mammals and is related to the 26S proteasome regulatory complex."
      Wei N. , Tsuge T. , Serino G. , Dohmae N. , Takio K. , Matsui M. , Deng X.-W.
      Curr. Biol.8:919-922(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];IDENTIFICATION IN THE CSN COMPLEX
    2. 2.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: C57BL/6J.
      tissue: Tongue.
    3. 3.
      Lubec G. , Klug S.
      Submitted (2007-03) to the UniProtKB
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 96-107; 154-170 AND 228-242;IDENTIFICATION BY MASS SPECTROMETRY
      tissue: Hippocampus.
    4. 4.
      "Solution structure of the PCI domain."
      RIKEN structural genomics initiative (RSGI)
      Submitted (2004-06) to the PDB data bank
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 296-366
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