Gene name:
Csrp3 (Clp;Mlp) ;
Protein name:
Cysteine and glycine-rich protein 3 ;
Alternative:
LIM domain protein, cardiac ;Cysteine-rich protein 3 (CRP3) ;Muscle LIM protein ;
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Interacts with LDHD (By similarity). Interacts with GLRX3.
Function:
Positive regulator of myogenesis. Plays a crucial and specific role in the organization of cytosolic structures in cardiomyocytes. Could play a role in mechanical stretch sensing. May be a scaffold protein that promotes the assembly of interacting proteins at Z-line structures. It is essential for calcineurin anchorage to the Z line. Required for stress-induced calcineurin-NFAT activation.
Subcellular Location:
Nucleus
Cytoplasm
Cytoplasm
cytoskeleton
Cytoplasm
myofibril
sarcomere
Z line
Mainly cytoplasmic. In the nucleus it associates with the actin cytoskeleton (Potential). In the Z line, found associated with GLRX3.
Protein Attributes:
50:
MPNWGGGAKC | GACEKTVYHA | EEIQCNGRSF | HKTCFHCMAC | RKALDSTTVA |
100:
AHESEIYCKV | CYGRRYGPKG | IGFGQGAGCL | STDTGEHLGL | QFQQSPKPAR |
150:
AATTSNPSKF | SAKFGESEKC | PRCGKSVYAA | EKVMGGGKPW | HKTCFRCAIC |
194:
GKSLESTNVT | DKDGELYCKV | CYAKNFGPTG | IGFGGLTQQV | EKKE
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
Rat
Bovine
ELISA Kit for Mouse Cysteine and glycine-rich protein 3
ELISA Kit for Mouse Cysteine and glycine-rich protein 3
ELISA Kit for Mouse Cysteine and glycine-rich protein 3
ELISA Kit for Mouse Cysteine and glycine-rich protein 3
CLIA Kit for Mouse Cysteine and glycine-rich protein 3
CLIA Kit for Mouse Cysteine and glycine-rich protein 3
CLIA Kit for Mouse Cysteine and glycine-rich protein 3
CLIA Kit for Mouse Cysteine and glycine-rich protein 3
Polyclonal Antibody for Mouse Cysteine and glycine-rich protein 3
Polyclonal Antibody for Mouse Cysteine and glycine-rich protein 3
Polyclonal Antibody for Mouse Cysteine and glycine-rich protein 3
Polyclonal Antibody for Mouse Cysteine and glycine-rich protein 3
Monoclonal Antibody for Mouse Cysteine and glycine-rich protein 3
Monoclonal Antibody for Mouse Cysteine and glycine-rich protein 3
Monoclonal Antibody for Mouse Cysteine and glycine-rich protein 3
Monoclonal Antibody for Mouse Cysteine and glycine-rich protein 3
Protein for Mouse Cysteine and glycine-rich protein 3
Protein for Mouse Cysteine and glycine-rich protein 3
Protein for Mouse Cysteine and glycine-rich protein 3
Protein for Mouse Cysteine and glycine-rich protein 3
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
strain :
MF1 .
tissue :
Mandible .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
strain :
C3H .
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue :
Liver .
4.
"MLP-deficient mice exhibit a disruption of cardiac cytoarchitectural organization, dilated cardiomyopathy, and heart failure."
Arber S.
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Hunter J.J.
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Ross J. Jr.
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Cell88:393-403(1997)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;DISRUPTION PHENOTYPE
strain :
129/Sv .
5.
"Attenuation of cardiac remodeling after myocardial infarction by muscle LIM protein-calcineurin signaling at the sarcomeric Z-disc."
Heineke J.
,
Ruetten H.
,
Willenbockel C.
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Gross S.C.
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Naguib M.
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Schaefer A.
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Proc. Natl. Acad. Sci. U.S.A.102:1655-1660(2005)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;DISRUPTION PHENOTYPE
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH GLRX3;SUBCELLULAR LOCATION
7.
"A common MLP (muscle LIM protein) variant is associated with cardiomyopathy."
Knoll R.
,
Kostin S.
,
Klede S.
,
Savvatis K.
,
Klinge L.
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Stehle I.
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Gunkel S.
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Kotter S.
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Babicz K.
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Sohns M.
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Didie M.
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Zimmermann W.H.
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Maier L.S.
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Schaper W.
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Tschope C.
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Linke W.A.
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Chien K.R.
more...
Circ. Res.106:695-704(2010)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : MUTAGENESIS OF TRP-4