Protein name:
Transcriptional repressor CTCFL ;
Alternative:
CCCTC-binding factor ;Brother of the regulator of imprinted sites ;CTCF-like protein ;CTCF paralog ;Zinc finger protein CTCF-T ;Cancer/testis antigen 27 (CT27) ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Interacts with histones, PRMT7 and SETD1A. Interacts (via N-terminus) with BAG6/BAT3.
Function:
Testis-specific DNA binding protein responsible for insulator function, nuclear architecture and transcriptional control, which probably acts by recruiting epigenetic chromatin modifiers. Plays a key role in gene imprinting in male germline, by participating in the establishment of differential methylation at the IGF2/H19 imprinted control region (ICR). Directly binds the unmethylated H19 ICR and recruits the PRMT7 methyltransferase, leading to methylate histone H4 'Arg-3' to form H4R3sme2. This probably leads to recruit de novo DNA methyltransferases at these sites (By similarity). Seems to act as tumor suppressor. In association with DNMT1 and DNMT3B, involved in activation of BAG1 gene expression by binding to its promoter. Required for dimethylation of H3 lysine 4 (H3K4me2) of MYC and BRCA1 promoters.
Subcellular Location:
Cytoplasm
Nucleus
Protein Attributes:
50:
MAATEISVLS | EQFTKIKELE | LMPEKGLKEE | EKDGVCREKD | HRSPSELEAE |
100:
RTSGAFQDSV | LEEEVELVLA | PSEESEKYIL | TLQTVHFTSE | AVELQDMSLL |
150:
SIQQQEGVQV | VVQQPGPGLL | WLEEGPRQSL | QQCVAISIQQ | ELYSPQEMEV |
200:
LQFHALEENV | MVASEDSKLA | VSLAETTGLI | KLEEEQEKNQ | LLAERTKEQL |
250:
FFVETMSGDE | RSDEIVLTVS | NSNVEEQEDQ | PTAGQADAEK | AKSTKNQRKT |
300:
KGAKGTFHCD | VCMFTSSRMS | SFNRHMKTHT | SEKPHLCHLC | LKTFRTVTLL |
350:
RNHVNTHTGT | RPYKCNDCNM | AFVTSGELVR | HRRYKHTHEK | PFKCSMCKYA |
400:
SVEASKLKRH | VRSHTGERPF | QCCQCSYASR | DTYKLKRHMR | THSGEKPYEC |
450:
HICHTRFTQS | GTMKIHILQK | HGENVPKYQC | PHCATIIARK | SDLRVHMRNL |
500:
HAYSAAELKC | RYCSAVFHER | YALIQHQKTH | KNEKRFKCKH | CSYACKQERH |
550:
MTAHIRTHTG | EKPFTCLSCN | KCFRQKQLLN | AHFRKYHDAN | FIPTVYKCSK |
600:
CGKGFSRWIN | LHRHSEKCGS | GEAKSAASGK | GRRTRKRKQT | ILKEATKGQK |
650:
EAAKGWKEAA | NGDEAAAEEA | STTKGEQFPG | EMFPVACRET | TARVKEEVDE |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
ELISA Kit for Human Transcriptional repressor CTCFL
ELISA Kit for Human Transcriptional repressor CTCFL
CLIA Kit for Human Transcriptional repressor CTCFL
CLIA Kit for Human Transcriptional repressor CTCFL
Polyclonal Antibody for Human Transcriptional repressor CTCFL
Polyclonal Antibody for Human Transcriptional repressor CTCFL
Monoclonal Antibody for Human Transcriptional repressor CTCFL
Monoclonal Antibody for Human Transcriptional repressor CTCFL
Protein for Human Transcriptional repressor CTCFL
Protein for Human Transcriptional repressor CTCFL
R&D Technical Data
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Precision
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Recovery
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Linearity
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Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3; 4; 5; 6; 7; 8; 9; 10 AND 11);FUNCTION;VARIANT ALA-177
tissue :
Testis .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
tissue :
Testis .
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANT ALA-177
tissue :
Testis .
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[
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[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANT ALA-177
tissue :
Testis .
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[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
6.
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Submitted (2005-09) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANT ALA-177
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : REVIEW
9.
"DNA methyltransferase 1 and 3B activate BAG-1 expression via recruitment of CTCFL/BORIS and modulation of promoter histone methylation."
Sun L.
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Huang L.
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Nguyen P.
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Bar-Sela G.
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Ho A.S.
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Gius D.
Cancer Res.68:2726-2735(2008)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION
10.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;INTERACTION WITH BAG6/BAT3 AND SETD1A