CATSPER2 ELISA Kit for Human(Homo sapiens) | EIAab.comCATSPER2 ELISA Kit for Human(Homo sapiens)

Search Protein-oriented Product center.

For antibodies, ELISA/CLIA, proteins... Product center

Tips

Index > Protein center > CATSPER2(Gene name) > Human

CATSPER2 (Gene name),

Cation channel sperm-associated protein 2 (Protein name ), CTSR2_HUMAN from NCBI database.

top

General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

Feedback

Gene name:

CATSPER2;

Protein name:

Cation channel sperm-associated protein 2(CatSper2);

Alternative:

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Heterotetramer; possibly composed of CATSPER1, CATSPER2, CATSPER3 and CATSPER4 (Potential). Interacts with Ca(v)3.3/CACNA1I, leading to suppress T-type calcium channel activity.

Function:

Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte. Activated by extracellular progesterone and prostaglandins following the sequence: progesterone > PGF1-alpha = PGE1 > PGA1 > PGE2 >> PGD2. The primary effect of progesterone activation is to shift voltage dependence towards more physiological, negative membrane potentials; it is not mediated by metabotropic receptors and second messengers. Sperm capacitation enhances the effect of progesterone by providing additional negative shift. Also activated by the elevation of intracellular pH.

Subcellular Location:

Cell projection cilium flagellum membrane Multi-pass membrane protein Specifically located in the principal piece of sperm tail.

Protein Attributes:

Sequence length:

530

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

530:

ELLEKLQYNL | EERKKLQEFA | VQALMNLEDK |

3D Structure:

N/A

Predicted Eptitope:

Please Sign in.

Vaild Sequence:

Please Sign in.

Related Databases

STRING:

9606.ENSP00000299989

SMR:

Q96P56

String:

Q96P56

KEGG:

hsa:117155

Pfam:

PF00520

UniGene:

Hs.662284

MIM:

607249

Uniprot:

Q96P56

FOR

ELISA Kit for Human CatSper2

CLIA Kit for Human CatSper2

Polyclonal Antibody for Human CatSper2

Monoclonal Antibody for Human CatSper2

Protein for Human CatSper2

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"A voltage-gated ion channel expressed specifically in spermatozoa."
Quill T.A. , Ren D. , Clapham D.E. , Garbers D.L.
Proc. Natl. Acad. Sci. U.S.A.98:12527-12531(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3);TISSUE SPECIFICITY
2.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 4)
tissue: Brain.
tissue: Testis.
3.

"CATSPER2, a human autosomal nonsyndromic male infertility gene."
Avidan N. , Tamary H. , Dgany O. , Cattan D. , Pariente A. , Thulliez M. , Borot N. , Moati L. , Barthelme A. , Shalmon L. , Krasnov T. , Ben-Asher E. , Olender T. , Khen M. , Yaniv I. , Zaizov R. , Shalev H. , Delaunay J. , more...
Eur. J. Hum. Genet.11:497-502(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN DIS
4.

"Association of Catsper1 or -2 with Ca(v)3.3 leads to suppression of T-type calcium channel activity."
Zhang D. , Chen J. , Saraf A. , Cassar S. , Han P. , Rogers J.C. , Brioni J.D. , Sullivan J.P. , Gopalakrishnan M.
J. Biol. Chem.281:22332-22341(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CACNA1I
5.

"Sensorineural deafness and male infertility: a contiguous gene deletion syndrome."
Zhang Y. , Malekpour M. , Al-Madani N. , Kahrizi K. , Zanganeh M. , Mohseni M. , Mojahedi F. , Daneshi A. , Najmabadi H. , Smith R.J.H.
J. Med. Genet.44:233-240(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN DIS
6.

"Expression of CatSper family transcripts in the mouse testis during post-natal development and human ejaculated spermatozoa: relationship to sperm motility."
Li H.-G. , Ding X.-F. , Liao A.-H. , Kong X.-B. , Xiong C.-L.
Mol. Hum. Reprod.13:299-306(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
7.

"The CatSper channel mediates progesterone-induced Ca2+ influx in human sperm."
Strunker T. , Goodwin N. , Brenker C. , Kashikar N.D. , Weyand I. , Seifert R. , Kaupp U.B.
Nature471:382-386(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN ACTIVATION BY PROGESTERONE
8.

"Progesterone activates the principal Ca2+ channel of human sperm."
Lishko P.V. , Botchkina I.L. , Kirichok Y.
Nature471:387-391(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN ACTIVATION BY PROGESTERONE

Product Feedback Wall

* Email:
*Comments: