Protein name:
Cation channel sperm-associated protein 4 (CatSper4) ;
Alternative:
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Heterotetramer; possibly composed of CATSPER1, CATSPER2, CATSPER3 and CATSPER4 (Potential). Interacts with CATSPER1.
Function:
Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte. Activated by extracellular progesterone and prostaglandins following the sequence: progesterone > PGF1-alpha = PGE1 > PGA1 > PGE2 >> PGD2. The primary effect of progesterone activation is to shift voltage dependence towards more physiological, negative membrane potentials; it is not mediated by metabotropic receptors and second messengers. Sperm capacitation enhances the effect of progesterone by providing additional negative shift. Also activated by the elevation of intracellular pH.
Subcellular Location:
Cell projection
cilium
flagellum membrane
Multi-pass membrane protein
Specifically located in the principal piece of sperm tail.
Protein Attributes:
50:
MRDNEKAWWQ | QWTSHTGLEG | WGGTQEDRMG | FGGAVAALRG | RPSPLQSTIH |
100:
ESYGRPEEQV | LINRQEITNK | ADAWDMQEFI | THMYIKQLLR | HPAFQLLLAL |
150:
LLVINAITIA | LRTNSYLDQK | HYELFSTIDD | IVLTILLCEV | LLGWLNGFWI |
200:
FWKDGWNILN | FIIVFILLLR | FFINEINIPS | INYTLRALRL | VHVCMAVEPL |
250:
ARIIRVILQS | VPDMANIMVL | ILFFMLVFSV | FGVTLFGAFV | PKHFQNIQVA |
300:
LYTLFICITQ | DGWVDIYSDF | QTEKREYAME | IGGAIYFTIF | ITIGAFIGIN |
350:
LFVIVVTTNL | EQMMKAGEQG | QQQRITFSET | GAEEEEENDQ | LPLVHCVVAR |
400:
SEKSGLLQEP | LAGGPLSNLS | ENTCDNFCLV | LEAIQENLRQ | YKEIRDELNM |
450:
IVEEVRAIRF | NQEQESEVLN | RRSSTSGSLE | TTSSKDIRQM | SQQQDLLSAL |
472:
VSMEKVHDSS | SQILLKKHKS | SH
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
ELISA Kit for Human CatSper4
ELISA Kit for Human CatSper4
CLIA Kit for Human CatSper4
CLIA Kit for Human CatSper4
Polyclonal Antibody for Human CatSper4
Polyclonal Antibody for Human CatSper4
Monoclonal Antibody for Human CatSper4
Monoclonal Antibody for Human CatSper4
Protein for Human CatSper4
Protein for Human CatSper4
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G.
,
Barlow K.F.
,
McLay K.E.
,
Kaul R.
,
Swarbreck D.
,
Dunham A.
,
Scott C.E.
,
Howe K.L.
,
Woodfine K.
,
Spencer C.C.A.
,
Jones M.C.
,
Gillson C.
,
Searle S.
,
Zhou Y.
,
Kokocinski F.
,
McDonald L.
,
Evans R.
,
Phillips K.
,
Atkinson A.
,
Cooper R.
,
Jones C.
,
Hall R.E.
,
Andrews T.D.
,
Lloyd C.
,
Ainscough R.
,
Almeida J.P.
,
Ambrose K.D.
,
Anderson F.
,
Andrew R.W.
,
Ashwell R.I.S.
,
Aubin K.
,
Babbage A.K.
,
Bagguley C.L.
,
Bailey J.
,
Beasley H.
,
Bethel G.
,
Bird C.P.
,
Bray-Allen S.
,
Brown J.Y.
,
Brown A.J.
,
Buckley D.
,
Burton J.
,
Bye J.
,
Carder C.
,
Chapman J.C.
,
Clark S.Y.
,
Clarke G.
,
Clee C.
,
Cobley V.
,
Collier R.E.
,
Corby N.
,
Coville G.J.
,
Davies J.
,
Deadman R.
,
Dunn M.
,
Earthrowl M.
,
Ellington A.G.
,
Errington H.
,
Frankish A.
,
Frankland J.
,
French L.
,
Garner P.
,
Garnett J.
,
Gay L.
,
Ghori M.R.J.
,
Gibson R.
,
Gilby L.M.
,
Gillett W.
,
Glithero R.J.
,
Grafham D.V.
,
Griffiths C.
,
Griffiths-Jones S.
,
Grocock R.
,
Hammond S.
,
Harrison E.S.I.
,
Hart E.
,
Haugen E.
,
Heath P.D.
,
Holmes S.
,
Holt K.
,
Howden P.J.
,
Hunt A.R.
,
Hunt S.E.
,
Hunter G.
,
Isherwood J.
,
James R.
,
Johnson C.
,
Johnson D.
,
Joy A.
,
Kay M.
,
Kershaw J.K.
,
Kibukawa M.
,
Kimberley A.M.
,
King A.
,
Knights A.J.
,
Lad H.
,
Laird G.
,
Lawlor S.
,
Leongamornlert D.A.
,
Lloyd D.M.
,
Loveland J.
,
Lovell J.
,
Lush M.J.
,
Lyne R.
,
Martin S.
,
Mashreghi-Mohammadi M.
,
Matthews L.
,
Matthews N.S.W.
,
McLaren S.
,
Milne S.
,
Mistry S.
,
Moore M.J.F.
,
Nickerson T.
,
O'Dell C.N.
,
Oliver K.
,
Palmeiri A.
,
Palmer S.A.
,
Parker A.
,
Patel D.
,
Pearce A.V.
,
Peck A.I.
,
Pelan S.
,
Phelps K.
,
Phillimore B.J.
,
Plumb R.
,
Rajan J.
,
Raymond C.
,
Rouse G.
,
Saenphimmachak C.
,
Sehra H.K.
,
Sheridan E.
,
Shownkeen R.
,
Sims S.
,
Skuce C.D.
,
Smith M.
,
Steward C.
,
Subramanian S.
,
Sycamore N.
,
Tracey A.
,
Tromans A.
,
Van Helmond Z.
,
Wall M.
,
Wallis J.M.
,
White S.
,
Whitehead S.L.
,
Wilkinson J.E.
,
Willey D.L.
,
Williams H.
,
Wilming L.
,
Wray P.W.
,
Wu Z.
,
Coulson A.
,
Vaudin M.
,
Sulston J.E.
,
Durbin R.M.
,
Hubbard T.
,
Wooster R.
,
Dunham I.
,
Carter N.P.
,
McVean G.
,
Ross M.T.
,
Harrow J.
,
Olson M.V.
,
Beck S.
,
Rogers J.
,
Bentley D.R.
more...
Nature441:315-321(2006)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
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Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
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Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
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Cited for : IDENTIFICATION;TISSUE SPECIFICITY
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Cited for : TISSUE SPECIFICITY
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Cited for : FUNCTION IN ACTIVATION BY PROGESTERONE
6.
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Cited for : FUNCTION IN ACTIVATION BY PROGESTERONE