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Index > Protein center > CATSPER4(Gene name) > Human
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  • CATSPER4 (Gene name),
  • Cation channel sperm-associated protein 4 (Protein name ),  CTSR4_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    CATSPER4;
    Protein name:
    Cation channel sperm-associated protein 4(CatSper4);
    Alternative:

    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Heterotetramer; possibly composed of CATSPER1, CATSPER2, CATSPER3 and CATSPER4 (Potential). Interacts with CATSPER1.
    Function:
    Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte. Activated by extracellular progesterone and prostaglandins following the sequence: progesterone > PGF1-alpha = PGE1 > PGA1 > PGE2 >> PGD2. The primary effect of progesterone activation is to shift voltage dependence towards more physiological, negative membrane potentials; it is not mediated by metabotropic receptors and second messengers. Sperm capacitation enhances the effect of progesterone by providing additional negative shift. Also activated by the elevation of intracellular pH.
    Subcellular Location:
    Cell projection cilium flagellum membrane Multi-pass membrane protein Specifically located in the principal piece of sperm tail.
    Protein Attributes:
    Sequence length:
    472
    Sequence:
    50:
    MRDNEKAWWQ | QWTSHTGLEG | WGGTQEDRMG | FGGAVAALRG | RPSPLQSTIH | 
    100:
    ESYGRPEEQV | LINRQEITNK | ADAWDMQEFI | THMYIKQLLR | HPAFQLLLAL | 
    150:
    LLVINAITIA | LRTNSYLDQK | HYELFSTIDD | IVLTILLCEV | LLGWLNGFWI | 
    200:
    FWKDGWNILN | FIIVFILLLR | FFINEINIPS | INYTLRALRL | VHVCMAVEPL | 
    250:
    ARIIRVILQS | VPDMANIMVL | ILFFMLVFSV | FGVTLFGAFV | PKHFQNIQVA | 
    300:
    LYTLFICITQ | DGWVDIYSDF | QTEKREYAME | IGGAIYFTIF | ITIGAFIGIN | 
    350:
    LFVIVVTTNL | EQMMKAGEQG | QQQRITFSET | GAEEEEENDQ | LPLVHCVVAR | 
    400:
    SEKSGLLQEP | LAGGPLSNLS | ENTCDNFCLV | LEAIQENLRQ | YKEIRDELNM | 
    450:
    IVEEVRAIRF | NQEQESEVLN | RRSSTSGSLE | TTSSKDIRQM | SQQQDLLSAL | 
    472:
    VSMEKVHDSS | SQILLKKHKS | SH
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    String:
    UniGene:
    SMR:
    MIM:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Human CatSper4
    ELISA Kit for Human CatSper4
    CLIA Kit for Human CatSper4
    CLIA Kit for Human CatSper4
    Polyclonal Antibody for Human CatSper4
    Polyclonal Antibody for Human CatSper4
    Monoclonal Antibody for Human CatSper4
    Monoclonal Antibody for Human CatSper4
    Protein for Human CatSper4
    Protein for Human CatSper4

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    References
    1. 1.
      "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G. , Barlow K.F. , McLay K.E. , Kaul R. , Swarbreck D. , Dunham A. , Scott C.E. , Howe K.L. , Woodfine K. , Spencer C.C.A. , Jones M.C. , Gillson C. , Searle S. , Zhou Y. , Kokocinski F. , McDonald L. , Evans R. , Phillips K. , more...
      Nature441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    2. 2.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
    3. 3.
      "Identification of human and mouse CatSper3 and CatSper4 genes: characterisation of a common interaction domain and evidence for expression in testis."
      Lobley A. , Pierron V. , Reynolds L. , Allen L. , Michalovich D.
      Reprod. Biol. Endocrinol.1:53-53(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION;TISSUE SPECIFICITY
    4. 4.
      "Expression of CatSper family transcripts in the mouse testis during post-natal development and human ejaculated spermatozoa: relationship to sperm motility."
      Li H.-G. , Ding X.-F. , Liao A.-H. , Kong X.-B. , Xiong C.-L.
      Mol. Hum. Reprod.13:299-306(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
    5. 5.
      "The CatSper channel mediates progesterone-induced Ca2+ influx in human sperm."
      Strunker T. , Goodwin N. , Brenker C. , Kashikar N.D. , Weyand I. , Seifert R. , Kaupp U.B.
      Nature471:382-386(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN ACTIVATION BY PROGESTERONE
    6. 6.
      "Progesterone activates the principal Ca2+ channel of human sperm."
      Lishko P.V. , Botchkina I.L. , Kirichok Y.
      Nature471:387-391(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN ACTIVATION BY PROGESTERONE
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