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Index > Protein center > Catsper4(Gene name) > Mouse
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  • Catsper4 (Gene name),
  • Cation channel sperm-associated protein 4 (Protein name ),  CTSR4_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    Catsper4;
    Protein name:
    Cation channel sperm-associated protein 4(CatSper4);
    Alternative:

    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Heterotetramer; possibly composed of CATSPER1, CATSPER2, CATSPER3 and CATSPER4 (Potential). Interacts with CATSPER1.
    Function:
    Voltage-gated calcium channel that plays a central role in sperm cell hyperactivation. Controls calcium entry to mediate the hyperactivated motility, a step needed for sperm motility which is essential late in the preparation of sperm for fertilization. Activated by intracellular alkalinization. Contrary to the human ortholog, not activated by progesterone.
    Subcellular Location:
    Cell projection cilium flagellum membrane Multi-pass membrane protein Specifically located in the principal piece of sperm tail.
    Protein Attributes:
    Sequence length:
    442
    Sequence:
    50:
    MSEKHKWWQQ | VENIDITHLG | PKRKAYELLG | RHEEQVLINR | RDVMEKKDAW | 
    100:
    DVQEFITQMY | IKQLLRHPAF | QLLLAFLLLS | NAITIALRTN | SYLGQKHYEL | 
    150:
    FSTIDDIVLT | ILICEVLLGW | LNGFWIFWKD | GWNILNFAIV | FILFMGFFIK | 
    200:
    QLDMVAITYP | LRVLRLVHVC | MAVEPLARII | KVILQSMPDL | ANVMALILFF | 
    250:
    MLVFSVFGVT | LFGAFVPKHF | QNMGVALYTL | FICITQDGWL | DIYTDFQMDE | 
    300:
    REYAMEVGGA | IYFAVFITLG | AFIGLNLFVV | VVTTNLEQMM | KTGEEEGHLN | 
    350:
    IKFTETEEDE | DWTDELPLVH | CTEARKDTST | VPKEPLVGGP | LSNLTEKTCD | 
    400:
    NFCLVLEAIQ | ENLMEYKEIR | EELNMIVEEV | SSIRFNQEQQ | NVILHKYTSK | 
    442:
    SATFLSEPPE | GANKQDLITA | LVSREKVSDS | NINMVNKHKF | SH
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    String:
    Pfam:
    SMR:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse CatSper4
    ELISA Kit for Mouse CatSper4
    CLIA Kit for Mouse CatSper4
    CLIA Kit for Mouse CatSper4
    Polyclonal Antibody for Mouse CatSper4
    Polyclonal Antibody for Mouse CatSper4
    Monoclonal Antibody for Mouse CatSper4
    Monoclonal Antibody for Mouse CatSper4
    Protein for Mouse CatSper4
    Protein for Mouse CatSper4

    R&D Technical Data
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Precision
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Recovery
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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    References
    1. 1.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: C57BL/6J.
      tissue: Testis.
    2. 2.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
      strain: C57BL/6J.
    3. 3.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
    4. 4.
      "Catsper3 and catsper4 encode two cation channel-like proteins exclusively expressed in the testis."
      Jin J.-L. , O'Doherty A.M. , Wang S. , Zheng H. , Sanders K.M. , Yan W.
      Biol. Reprod.73:1235-1242(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;TISSUE SPECIFICITY
    5. 5.
      "Expression of CatSper family transcripts in the mouse testis during post-natal development and human ejaculated spermatozoa: relationship to sperm motility."
      Li H.-G. , Ding X.-F. , Liao A.-H. , Kong X.-B. , Xiong C.-L.
      Mol. Hum. Reprod.13:299-306(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DEVELOPMENTAL STAGE
    6. 6.
      "Catsper3 and catsper4 are essential for sperm hyperactivated motility and male fertility in the mouse."
      Jin J.-L. , Jin N. , Zheng H. , Ro S. , Tafolla D. , Sanders K.M. , Yan W.
      Biol. Reprod.77:37-44(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DISRUPTION PHENOTYPE
    7. 7.
      "All four CatSper ion channel proteins are required for male fertility and sperm cell hyperactivated motility."
      Qi H. , Moran M.M. , Navarro B. , Chong J.A. , Krapivinsky G. , Krapivinsky L. , Kirichok Y. , Ramsey I.S. , Quill T.A. , Clapham D.E.
      Proc. Natl. Acad. Sci. U.S.A.104:1219-1223(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;TISSUE SPECIFICITY;INTERACTION WITH CATSPER1;DISRUPTION PHENOTYPE
    8. 8.
      "Progesterone activates the principal Ca2+ channel of human sperm."
      Lishko P.V. , Botchkina I.L. , Kirichok Y.
      Nature471:387-391(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: LACK OF ACTIVATION BY PROGESTERONE AND PGE1
    9. 9.
      "A novel gene required for male fertility and functional CATSPER channel formation in spermatozoa."
      Chung J.J. , Navarro B. , Krapivinsky G. , Krapivinsky L. , Clapham D.E.
      Nat. Commun.2:153-153(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION IN THE CATSPER COMPLEX
      strain: C57BL/6.
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