CYBB ELISA Kit for Human(Homo sapiens) | EIAab.comCYBB ELISA Kit for Human(Homo sapiens)

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CYBB (Gene name),

Cytochrome b-245 heavy chain (Protein name ), CY24B_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

CYBB(NOX2);

Protein name:

Cytochrome b-245 heavy chain;

Alternative:

Cytochrome b(558) subunit beta(Cytochrome b558 subunit beta);CGD91-phox;NADPH oxidase 2;Heme-binding membrane glycoprotein gp91phox;Superoxide-generating NADPH oxidase heavy chain subunit;Neutrophil cytochrome b 91 kDa polypeptide;gp91-phox;gp91-1;p22 phagocyte B-cytochrome;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Composed of a heavy chain (beta) and a light chain (alpha).

Function:

Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. It is the terminal component of a respiratory chain that transfers single electrons from cytoplasmic NADPH across the plasma membrane to molecular oxygen on the exterior. Also functions as a voltage-gated proton channel that mediates the H(+) currents of resting phagocytes. It participates in the regulation of cellular pH and is blocked by zinc.

Subcellular Location:

Membrane Multi-pass membrane protein

Protein Attributes:

Sequence length:

570

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

570:

ISNSESGPRG | VHFIFNKENF |

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

KEGG:

hsa:1536

UniGene:

Hs.292356

SMR:

P04839

String:

P04839

Pfam:

PF08022

STRING:

9606.ENSP00000367851

MIM:

300481

Uniprot:

P04839

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ELISA Kit for Human Cytochrome b-245 heavy chain

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E10150h

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96T

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ELISA Kit for Human Cytochrome b-245 heavy chain

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E10150m

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96T

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ELISA Kit for Human Cytochrome b-245 heavy chain

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E10150b

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96T

ELISA Kit for Human Cytochrome b-245 heavy chain

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E10150p

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96T

CLIA Kit for Human Cytochrome b-245 heavy chain

Cat.:

U10150b

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96T

CLIA Kit for Human Cytochrome b-245 heavy chain

Cat.:

U10150p

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Packing:

96T

CLIA Kit for Human Cytochrome b-245 heavy chain

Cat.:

U10150m

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MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Human Cytochrome b-245 heavy chain

Cat.:

U10150h

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Packing:

96T

Polyclonal Antibody for Human Cytochrome b-245 heavy chain

Cat.:

P10150Rb-m

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40ug/0.2ml

Polyclonal Antibody for Human Cytochrome b-245 heavy chain

Cat.:

P10150Rb-h

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Packing:

40ug/0.2ml

Monoclonal Antibody for Human Cytochrome b-245 heavy chain

Protein for Human Cytochrome b-245 heavy chain

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"Cloning the gene for an inherited human disorder -- chronic granulomatous disease -- on the basis of its chromosomal location."
Royer-Pokora B. , Kunkel L.M. , Monaco A.P. , Goff S.C. , Newburger P.E. , Baehner R.L. , Cole F.S. , Curnutte J.T. , Orkin S.H.
Nature322:32-38(1986) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
2.

"CYBB mutation analysis in X-linked chronic granulomatous disease."
Jirapongsananuruk O. , Niemela J.E. , Malech H.L. , Fleisher T.A.
Clin. Immunol.104:73-76(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS CGD ASP-41 AND ARG-537;VARIANTS ARG-364 AND GLU-517
3.

NHLBI resequencing and genotyping service (RS&G)
Submitted (2005-12) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
4.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Brain.
5.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-09) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
6.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Lymph.
7.

"The glycoprotein encoded by the X-linked chronic granulomatous disease locus is a component of the neutrophil cytochrome b complex."
Dinauer M.C. , Orkin S.H. , Brown R. , Jesaitis A.J. , Parkos C.A.
Nature327:717-720(1987) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-135
8.

"Nonhomologous recombination between the cytochrome b558 heavy chain gene (CYBB) and LINE-1 causes an X-linked chronic granulomatous disease."
Kumatori A. , Faizunnessa N.N. , Suzuki S. , Moriuchi T. , Kurozumi H. , Nakamura M.
Genomics53:123-128(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 233-267
tissue: Peripheral blood.
9.

"The X-linked chronic granulomatous disease gene codes for the beta-chain of cytochrome b-245."
Teahan C. , Rowe P. , Parker P. , Totty N. , Segal A.W.
Nature327:720-721(1987) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 2-44;SUBUNIT
10.

"Evidence that the product of the human X-linked CGD gene, gp91-phox, is a voltage-gated H(+) pathway."
Henderson L.M. , Meech R.W.
J. Gen. Physiol.114:771-786(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION AS A PROTON CHANNEL
11.

"Regulation of the phagocyte NADPH oxidase activity: phosphorylation of gp91phox/NOX2 by protein kinase C enhances its diaphorase activity and binding to Rac2, p67phox, and p47phox."
Raad H. , Paclet M.H. , Boussetta T. , Kroviarski Y. , Morel F. , Quinn M.T. , Gougerot-Pocidalo M.A. , Dang P.M. , El-Benna J.
FASEB J.23:1011-1022(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBUNIT;PHOSPHORYLATION;TISSUE SPECIFICITY
12.

"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
Chen R. , Jiang X. , Sun D. , Han G. , Wang F. , Ye M. , Wang L. , Zou H.
J. Proteome Res.8:651-661(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-132; ASN-149 AND ASN-240
tissue: Liver.
13.

"Interaction of human neutrophil flavocytochrome b with cytosolic proteins: transferred-NOESY NMR studies of a gp91phox C-terminal peptide bound to p47phox."
Adams E.R. , Dratz E.A. , Gizachew D. , Deleo F.R. , Yu L. , Volpp B.D. , Vlases M. , Jesaitis A.J. , Quinn M.T.
Biochem. J.325:249-257(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 556-570 IN COMPLEX WITH NCF1;INTERACTION WITH NCF1
14.

"A missense mutation in the neutrophil cytochrome b heavy chain in cytochrome-positive X-linked chronic granulomatous disease."
Dinauer M.C. , Curnutte J.T. , Rosen H.R. , Orkin S.H.
J. Clin. Invest.84:2012-2016(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN CGD;VARIANT CGD HIS-415
15.

"Point mutations in the beta-subunit of cytochrome b558 leading to X-linked chronic granulomatous disease."
Bolscher B.G.J.M. , de Boer M. , de Klein A. , Weening R.S. , Roos D.
Blood77:2482-2487(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS CGD ARG-101; THR-156; TYR-209; SER-244 AND ALA-389
16.

"A newly recognized point mutation in the cytochrome b558 heavy chain gene replacing alanine57 by glutamic acid, in a patient with cytochrome b positive X-linked chronic granulomatous disease."
Ariga T. , Sakiyama Y. , Tomizawa K. , Imajoh-Ohmi S. , Kanegasaki S. , Matsumoto S.
Eur. J. Pediatr.152:469-472(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT CGD GLU-57
17.

"Two novel point mutations in the cytochrome b 558 heavy chain gene, detected in two Japanese patients with X-linked chronic granulomatous disease."
Ariga T. , Sakiyama Y. , Matsumoto S.
Hum. Genet.94:441-441(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT CGD HIS-339
18.

"A point mutation in gp91-phox of cytochrome b558 of the human NADPH oxidase leading to defective translocation of the cytosolic proteins p47-phox and p67-phox."
Leusen J.H.W. , de Boer M. , Bolscher B.G.J.M. , Hilarius P.M. , Weening R.S. , Ochs H.D. , Roos D. , Verhoeven A.J.
J. Clin. Invest.93:2120-2126(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT CGD GLY-500
19.

"Identification of mutations in seven Chinese patients with X-linked chronic granulomatous disease."
Hui Y.F. , Chan S.Y. , Lau Y.L.
Blood88:4021-4028(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS CGD ILE-205; PHE-215 DEL AND GLN-342
20.

Hui Y.F. , Chan S.Y. , Lau Y.L.
Blood89:1843-1843(1996)

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ERRATUM
21.

"An in-frame triplet deletion within the gp91-phox gene in an adult X-linked chronic granulomatous disease patient with residual NADPH-oxidase activity."
Jendrossek V. , Ritzel A. , Neubauer B. , Heyden S. , Gahr M.
Eur. J. Haematol.58:78-85(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT CGD PHE-215 DEL
22.

"X-linked chronic granulomatous disease: mutations in the CYBB gene encoding the gp91-phox component of respiratory-burst oxidase."
Rae J. , Newburger P.E. , Dinauer M.C. , Noack D. , Hopkins P.J. , Kuruto R. , Curnutte J.T.
Am. J. Hum. Genet.62:1320-1331(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS CGD ARG-20; SER-54; ARG-59; ARG-119; THR-156; GLN-209; ASN-222; ARG-222; TYR-222; LEU-223; ARG-244; LYS-309; LYS-315 DEL; GLU-322; PHE-325; PRO-333; HIS-339; PRO-356; ARG-405; GLU-408; ARG-408; HIS-415; LEU-415; PRO-422; ARG-453; CYS-516; ASP-534 AND ARG-537
23.

"A novel mutation at a probable heme-binding ligand in neutrophil cytochrome b558 in atypical X-linked chronic granulomatous disease."
Tsuda M. , Kaneda M. , Sakiyama T. , Inana I. , Owada M. , Kiryu C. , Shiraishi T. , Kakinuma K.
Hum. Genet.103:377-381(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT CGD TYR-101
24.

"Nicotinamide-adenine dinucleotide phosphate oxidase assembly and activation in EBV-transformed B lymphoblastoid cell lines of normal and chronic granulomatous disease patients."
Dusi S. , Nadalini K.A. , Donini M. , Zentilin L. , Wientjes F.B. , Roos D. , Giacca M. , Rossi F.
J. Immunol.161:4968-4974(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS CGD ARG-179 AND 298-THR--THR-302 DEL
25.

"Genetic analysis of 13 families with X-linked chronic granulomatous disease reveals a low proportion of sporadic patients and a high proportion of sporadic carriers."
Ariga T. , Furuta H. , Cho K. , Sakiyama Y.
Pediatr. Res.44:85-92(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS CGD MET-54; ASP-55; GLU-57; HIS-339 AND PHE-344
26.

"Uncommon missense and splice mutations and resulting biochemical phenotypes in German patients with X-linked chronic granulomatous disease."
Roesler J. , Heyden S. , Burdelski M. , Schaefer H. , Kreth H.-W. , Lehmann R. , Paul D. , Marzahn J. , Gahr M. , Roesen-Wolff A.
Exp. Hematol.27:505-511(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS CGD PHE-193; ARG-222; TYR-338; HIS-339 AND PRO-546;VARIANT ARG-364
27.

"Molecular analysis of chronic granulomatous disease caused by defects in gp91-phox."
Patino P.J. , Perez J.E. , Lopez J.A. , Condino-Neto A. , Grumach A.S. , Botero J.H. , Curnutte J.T. , Garcia de Olarte D.
Hum. Mutat.13:29-37(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS CGD VAL-225 AND TYR-244
28.

"Statistical and mutational analysis of chronic granulomatous disease in Japan with special reference to gp91-phox and p22-phox deficiency."
Ishibashi F. , Nunoi H. , Endo F. , Matsuda I. , Kanegasaki S.
Hum. Genet.106:473-481(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS CGD MET-54; ASP-55; GLU-57; TYR-101; ARG-209; GLY-224; LYS-309; TYR-338; HIS-339; PHE-344; GLU-389; PRO-420 AND ARG-516
29.

"Characterization of 11 novel mutations in the X-linked chronic granulomatous disease (CYBB gene)."
Gerard B. , El Benna J. , Alcain F. , Gougerot-Pocidalo M.-A. , Grandchamp B. , Chollet-Martin S.
Hum. Mutat.18:163-163(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS CGD 54-ARG-ALA-55 DEL; TRP-59; PRO-307 AND ARG-505
30.

"Molecular and functional characterization of a new X-linked chronic granulomatous disease variant (X91+) case with a double missense mutation in the cytosolic gp91phox C-terminal tail."
Stasia M.J. , Lardy B. , Maturana A. , Rousseau P. , Martel C. , Bordigoni P. , Demaurex N. , Morel F.
Biochim. Biophys. Acta1586:316-330(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS CGD ASN-303 AND ARG-304
31.

"Functional analysis of two-amino acid substitutions in gp91 phox in a patient with X-linked flavocytochrome b558-positive chronic granulomatous disease by means of transgenic PLB-985 cells."
Bionda C. , Li X.J. , van Bruggen R. , Eppink M. , Roos D. , Morel F. , Stasia M.-J.
Hum. Genet.115:418-427(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION OF VARIANTS CGD ASN-303 AND ARG-304
32.

"First report of clinical, functional, and molecular investigation of chronic granulomatous disease in nine Jordanian families."
Bakri F.G. , Martel C. , Khuri-Bulos N. , Mahafzah A. , El-Khateeb M.S. , Al-Wahadneh A.M. , Hayajneh W.A. , Hamamy H.A. , Maquet E. , Molin M. , Stasia M.J.
J. Clin. Immunol.29:215-230(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT CGD ARG-408
33.

"Germline CYBB mutations that selectively affect macrophages in kindreds with X-linked predisposition to tuberculous mycobacterial disease."
Bustamante J. , Arias A.A. , Vogt G. , Picard C. , Galicia L.B. , Prando C. , Grant A.V. , Marchal C.C. , Hubeau M. , Chapgier A. , de Beaucoudrey L. , Puel A. , Feinberg J. , Valinetz E. , Janniere L. , Besse C. , Boland A. , Brisseau J.M. , more...
Nat. Immunol.12:213-221(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS IMD34 PRO-178 AND PRO-231
34.

"Identification and functional characterization of two novel mutations in the alpha-helical loop (residues 484-503) of CYBB/gp91(phox) resulting in the rare X91(+) variant of chronic granulomatous disease."
Boog B. , Quach A. , Costabile M. , Smart J. , Quinn P. , Singh H. , Gold M. , Booker G. , Choo S. , Hii C.S. , Ferrante A.
Hum. Mutat.33:471-475(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS CGD ASP-488 AND GLU-500
35.

"Clinical, functional, and genetic characterization of chronic granulomatous disease in 89 Turkish patients."
Koeker M.Y. , Camcioglu Y. , van Leeuwen K. , Kilic S.S. , Barlan I. , Yilmaz M. , Metin A. , de Boer M. , Avcilar H. , Patiroglu T. , Yildiran A. , Yegin O. , Tezcan I. , Sanal O. , Roos D.
J. Allergy Clin. Immunol.132:1156-1163(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS CGD ASN-299; ASP-338; HIS-339; PHE-344 AND GLU-412

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