Protein name:
Calcyclin-binding protein (CacyBP) ;
Alternative:
Siah-interacting protein ;
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Monomer or homodimer. Component of some large E3 complex at least composed of UBE2D1, SIAH1, CACYBP/SIP, SKP1, APC and TBL1X. Interacts directly with SIAH1, SIAH2 and SKP1 (By similarity). Interacts with proteins of the S100 family S100A1, S100A6, S100B, S100P and S100A12 at physiological calcium concentrations.
Function:
May be involved in calcium-dependent ubiquitination and subsequent proteasomal degradation of target proteins. Probably serves as a molecular bridge in ubiquitin E3 complexes. Participates in the ubiquitin-mediated degradation of beta-catenin (CTNNB1).
Subcellular Location:
Nucleus
Cytoplasm
Cytoplasmic in unstimulated cultured neurons. Upon increase of calcium, it localizes to a ring around the nucleus. In neuroblastoma cells, after a Retinoic acid (RA) induction and calcium increase, it localizes in both the nucleus and cytoplasm. The nuclear and perinuclear fractions may be phosphorylated.
Protein Attributes:
50:
MASVLEELQK | DLEEVKVLLE | KSTRKRLRDT | LTSEKSKIET | ELKNKMQQKS |
100:
QKKPELDNEK | PAAVVAPLTT | GYTVKISNYG | WDQSDKFVKI | YITLTGVHQV |
150:
PTENVQVHFT | ERSFDLLVKN | LNGKNYSMIV | NNLLKPISVE | SSSKKVKTDT |
200:
VIILCRKKAE | NTRWDYLTQV | EKECKEKEKP | SYDTEADPSE | GLMNVLKKIY |
229:
EDGDDDMKRT | INKAWVESRE | KQAREDTEF
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
Rat
Bovine
ELISA Kit for Mouse CacyBP
ELISA Kit for Mouse CacyBP
ELISA Kit for Mouse CacyBP
ELISA Kit for Mouse CacyBP
CLIA Kit for Mouse CacyBP
CLIA Kit for Mouse CacyBP
CLIA Kit for Mouse CacyBP
CLIA Kit for Mouse CacyBP
Polyclonal Antibody for Mouse CacyBP
Polyclonal Antibody for Mouse CacyBP
Polyclonal Antibody for Mouse CacyBP
Polyclonal Antibody for Mouse CacyBP
Monoclonal Antibody for Mouse CacyBP
Monoclonal Antibody for Mouse CacyBP
Monoclonal Antibody for Mouse CacyBP
Monoclonal Antibody for Mouse CacyBP
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
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Cited for : NUCLEOTIDE SEQUENCE [MRNA];PROTEIN SEQUENCE OF 17-22; 73-85 AND 222-229;TISSUE SPECIFICITY;INTERACTION WITH S100A6
tissue :
Brain .
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Science309:1559-1563(2005)
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[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain :
C57BL/6J .
tissue :
Embryo .
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH S100A6
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : SUBCELLULAR LOCATION;PHOSPHORYLATION
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : STRUCTURE BY NMR OF 1-77;INTERACTION WITH SKP1 AND S100A6;SUBUNIT
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : STRUCTURE BY NMR OF 189-219 IN COMPLEX WITH S100A6;INTERACTION WITH S100A6