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Index > Protein center > Cacybp(Gene name) > Mouse
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  • Cacybp (Gene name),
  • Calcyclin-binding protein (Protein name ),  CYBP_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    Cacybp(Sip);
    Protein name:
    Calcyclin-binding protein(CacyBP);
    Alternative:
    Siah-interacting protein;
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Monomer or homodimer. Component of some large E3 complex at least composed of UBE2D1, SIAH1, CACYBP/SIP, SKP1, APC and TBL1X. Interacts directly with SIAH1, SIAH2 and SKP1 (By similarity). Interacts with proteins of the S100 family S100A1, S100A6, S100B, S100P and S100A12 at physiological calcium concentrations.
    Function:
    May be involved in calcium-dependent ubiquitination and subsequent proteasomal degradation of target proteins. Probably serves as a molecular bridge in ubiquitin E3 complexes. Participates in the ubiquitin-mediated degradation of beta-catenin (CTNNB1).
    Subcellular Location:
    Nucleus Cytoplasm Cytoplasmic in unstimulated cultured neurons. Upon increase of calcium, it localizes to a ring around the nucleus. In neuroblastoma cells, after a Retinoic acid (RA) induction and calcium increase, it localizes in both the nucleus and cytoplasm. The nuclear and perinuclear fractions may be phosphorylated.
    Protein Attributes:
    Sequence length:
    229
    Sequence:
    50:
    MASVLEELQK | DLEEVKVLLE | KSTRKRLRDT | LTSEKSKIET | ELKNKMQQKS | 
    100:
    QKKPELDNEK | PAAVVAPLTT | GYTVKISNYG | WDQSDKFVKI | YITLTGVHQV | 
    150:
    PTENVQVHFT | ERSFDLLVKN | LNGKNYSMIV | NNLLKPISVE | SSSKKVKTDT | 
    200:
    VIILCRKKAE | NTRWDYLTQV | EKECKEKEKP | SYDTEADPSE | GLMNVLKKIY | 
    229:
    EDGDDDMKRT | INKAWVESRE | KQAREDTEF
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    KEGG:
    Pfam:
    String:
    UniGene:
    SMR:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse CacyBP
    ELISA Kit for Mouse CacyBP
    ELISA Kit for Mouse CacyBP
    ELISA Kit for Mouse CacyBP
    CLIA Kit for Mouse CacyBP
    CLIA Kit for Mouse CacyBP
    CLIA Kit for Mouse CacyBP
    CLIA Kit for Mouse CacyBP
    Polyclonal Antibody for Mouse CacyBP
    Polyclonal Antibody for Mouse CacyBP
    Polyclonal Antibody for Mouse CacyBP
    Polyclonal Antibody for Mouse CacyBP
    Monoclonal Antibody for Mouse CacyBP
    Monoclonal Antibody for Mouse CacyBP
    Monoclonal Antibody for Mouse CacyBP
    Monoclonal Antibody for Mouse CacyBP
    Protein for Mouse CacyBP
    Protein for Mouse CacyBP
    Protein for Mouse CacyBP
    Protein for Mouse CacyBP

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    Precision
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    Linearity
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    References
    1. 1.
      "Molecular cloning and expression of a mouse brain cDNA encoding a novel protein target of calcyclin."
      Filipek A. , Kuznicki J.
      J. Neurochem.70:1793-1798(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];PROTEIN SEQUENCE OF 17-22; 73-85 AND 222-229;TISSUE SPECIFICITY;INTERACTION WITH S100A6
      tissue: Brain.
    2. 2.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: C57BL/6J.
      tissue: Embryo.
    3. 3.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
    4. 4.
      "Characterization of the interaction of calcyclin (S100A6) and calcyclin-binding protein."
      Nowotny M. , Bhattacharya S. , Filipek A. , Krezel A.M. , Chazin W. , Kuznicki J.
      J. Biol. Chem.275:31178-31182(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH S100A6
    5. 5.
      "Ca2+-dependent translocation of the calcyclin-binding protein in neurons and neuroblastoma NB-2a cells."
      Filipek A. , Jastrzebska B. , Nowotny M. , Kwiatkowska K. , Hetman M. , Surmacz L. , Wyroba E. , Kuznicki J.
      J. Biol. Chem.277:21103-21109(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;PHOSPHORYLATION
    6. 6.
      "The modular structure of SIP facilitates its role in stabilizing multiprotein assemblies."
      Bhattacharya S. , Lee Y.-T. , Michowski W. , Jastrzebska B. , Filipek A. , Kuznicki J. , Chazin W.J.
      Biochemistry44:9462-9471(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 1-77;INTERACTION WITH SKP1 AND S100A6;SUBUNIT
    7. 7.
      "Structure of the S100A6 complex with a fragment from the C-terminal domain of Siah-1 interacting protein: a novel mode for S100 protein target recognition."
      Lee Y.-T. , Dimitrova Y.N. , Schneider G. , Ridenour W.B. , Bhattacharya S. , Soss S.E. , Caprioli R.M. , Filipek A. , Chazin W.J.
      Biochemistry47:10921-10932(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 189-219 IN COMPLEX WITH S100A6;INTERACTION WITH S100A6
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