DAPK2 ELISA Kit for Human(Homo sapiens) | EIAab.comDAPK2 ELISA Kit for Human(Homo sapiens)

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DAPK2 (Gene name),

Death-associated protein kinase 2 (Protein name ), DAPK2_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

DAPK2;

Protein name:

Death-associated protein kinase 2(DAP kinase 2);

Alternative:

DAP-kinase-related protein 1(DRP-1);

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Homodimer. Homodimerization is required for apoptotic function and is inhibited by autophosphorylation at Ser-318.

Function:

Calcium/calmodulin-dependent serine/threonine kinase which acts as a positive regulator of apoptosis.

Subcellular Location:

Cytoplasm

Protein Attributes:

Sequence length:

370

Sequence:

50:

100:

150:

200:

250:

300:

350:

370:

TEEDIARRKA | LHPRRRSSTS |

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

String:

Q9UIK4

KEGG:

hsa:23604

STRING:

9606.ENSP00000261891

UniGene:

Hs.237886

SMR:

Q9UIK4

Pfam:

PF00069

Uniprot:

Q9UIK4

FOR

ELISA Kit for Human DAP kinase 2

CLIA Kit for Human DAP kinase 2

Polyclonal Antibody for Human DAP kinase 2

Monoclonal Antibody for Human DAP kinase 2

Protein for Human DAP kinase 2

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Death-associated protein kinase 2 is a new calcium/calmodulin-dependent protein kinase that signals apoptosis through its catalytic activity."
Kawai T. , Nomura F. , Hoshino K. , Copeland N.G. , Gilbert D.J. , Jenkins N.A. , Akira S.
Oncogene18:3471-3480(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];FUNCTION;ENZYME REGULATION;TISSUE SPECIFICITY;MUTAGENESIS OF LYS-52
tissue: Skeletal muscle.
2.

"Death-associated protein kinase-related protein 1, a novel serine/threonine kinase involved in apoptosis."
Inbal B. , Shani G. , Cohen O. , Kissil J.L. , Kimchi A.
Mol. Cell. Biol.20:1044-1054(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];FUNCTION;SUBCELLULAR LOCATION;HOMODIMERIZATION;MUTAGENESIS OF LYS-52
tissue: Kidney.
3.

"New modularity of DAP-kinases: alternative splicing of the DRP-1 gene produces a ZIPk-like isoform."
Shoval Y. , Berissi H. , Kimchi A. , Pietrokovski S.
PLoS ONE6:E17344-E17344(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);FUNCTION (ISOFORM 2);TISSUE SPECIFICITY;INTERACTION WITH ATF4 (ISOFORM 2)
4.

"Analysis of the DNA sequence and duplication history of human chromosome 15."
Zody M.C. , Garber M. , Sharpe T. , Young S.K. , Rowen L. , O'Neill K. , Whittaker C.A. , Kamal M. , Chang J.L. , Cuomo C.A. , Dewar K. , FitzGerald M.G. , Kodira C.D. , Madan A. , Qin S. , Yang X. , Abbasi N. , Abouelleil A. , more...
Nature440:671-675(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
5.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
6.

"Autophosphorylation restrains the apoptotic activity of DRP-1 kinase by controlling dimerization and calmodulin binding."
Shani G. , Henis-Korenblit S. , Jona G. , Gileadi O. , Eisenstein M. , Ziv T. , Admon A. , Kimchi A.
EMBO J.20:1099-1113(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;HOMODIMERIZATION;MUTAGENESIS OF LYS-52; SER-299; SER-318; SER-320; SER-323 AND THR-329;PHOSPHORYLATION AT SER-318
7.

"The DAP-kinase family of proteins: study of a novel group of calcium-regulated death-promoting kinases."
Shohat G. , Shani G. , Eisenstein M. , Kimchi A.
Biochim. Biophys. Acta1600:45-50(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
8.

"DAP kinase and DRP-1 mediate membrane blebbing and the formation of autophagic vesicles during programmed cell death."
Inbal B. , Bialik S. , Sabanay I. , Shani G. , Kimchi A.
J. Cell Biol.157:455-468(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION
9.

"The death-associated protein kinases: structure, function, and beyond."
Bialik S. , Kimchi A.
Annu. Rev. Biochem.75:189-210(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON FUNCTION
10.

"The death-associated protein kinase 2 is up-regulated during normal myeloid differentiation and enhances neutrophil maturation in myeloid leukemic cells."
Rizzi M. , Tschan M.P. , Britschgi C. , Britschgi A. , Huegli B. , Grob T.J. , Leupin N. , Mueller B.U. , Simon H.U. , Ziemiecki A. , Torbett B.E. , Fey M.F. , Tobler A.
J. Leukoc. Biol.81:1599-1608(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INDUCTION;TISSUE SPECIFICITY
11.

"A quantitative atlas of mitotic phosphorylation."
Dephoure N. , Zhou C. , Villen J. , Beausoleil S.A. , Bakalarski C.E. , Elledge S.J. , Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A.105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-349;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
12.

"Down-regulation of death-associated protein kinase-2 is required for beta-catenin-induced anoikis resistance of malignant epithelial cells."
Li H. , Ray G. , Yoo B.H. , Erdogan M. , Rosen K.V.
J. Biol. Chem.284:2012-2022(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
13.

"Patterns of somatic mutation in human cancer genomes."
Greenman C. , Stephens P. , Smith R. , Dalgliesh G.L. , Hunter C. , Bignell G. , Davies H. , Teague J. , Butler A. , Stevens C. , Edkins S. , O'Meara S. , Vastrik I. , Schmidt E.E. , Avis T. , Barthorpe S. , Bhamra G. , Buck G. , more...
Nature446:153-158(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS [LARGE SCALE ANALYSIS] TRP-60 AND TRP-271

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