DCPS ELISA Kit for Human(Homo sapiens) | EIAab.comDCPS ELISA Kit for Human(Homo sapiens)

Search Protein-oriented Product center.

For antibodies, ELISA/CLIA, proteins... Product center

Tips

Index > Protein center > DCPS(Gene name) > Human

DCPS (Gene name),

Scavenger mRNA-decapping enzyme DcpS (Protein name ), DCPS_HUMAN from NCBI database.

top

General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

Feedback

Gene name:

DCPS(HSPC015;DCS1;HINT5);

Protein name:

Scavenger mRNA-decapping enzyme DcpS;

Alternative:

Hint-related 7meGMP-directed hydrolase;DCS-1;Histidine triad nucleotide-binding protein 5;Histidine triad protein member 5(HINT-5);Scavenger mRNA-decapping enzyme DcpS;Histidine triad protein member 5(HINT-5);

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Homodimer. Associates with components of the exosome multienzyme ribonuclease complex, such as EXOSC3 and EXOSC4.

Function:

Necessary for the complete degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Removes the 7-methyl guanine cap structure from mRNA fragments shorter than 10 nucleotides that are produced by 3'->5' exosome-mediated mRNA decay. Releases m7GMP. Can also degrade m7GDP to m7GMP. Has no activity towards mRNA molecules longer than 25 nucleotides.

Subcellular Location:

Cytoplasm Nucleus

Protein Attributes:

Sequence length:

337

Sequence:

50:

100:

150:

200:

250:

300:

337:

VIENLECDPR | HYQQRTLTFA | LRADDPLLKL | LQEAQQS

3D Structure:

N/A

Predicted Eptitope:

Please Sign in.

Vaild Sequence:

Please Sign in.

Related Databases

SMR:

Q96C86

MIM:

610534

Pfam:

PF05652

UniGene:

Hs.504249

String:

Q96C86

KEGG:

hsa:28960

STRING:

9606.ENSP00000263579

Uniprot:

Q96C86

FOR

ELISA Kit for Human Scavenger mRNA-decapping enzyme DcpS

CLIA Kit for Human Scavenger mRNA-decapping enzyme DcpS

Polyclonal Antibody for Human Scavenger mRNA-decapping enzyme DcpS

Monoclonal Antibody for Human Scavenger mRNA-decapping enzyme DcpS

Protein for Human Scavenger mRNA-decapping enzyme DcpS

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Cloning and characterization of a novel member of the histidine triad protein family (HINT-5) in different vertebrate species."
Huang C.-H. , Peng J. , Chen H. , Chen Y.
Submitted (2001-06) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA]
2.

"The scavenger mRNA decapping enzyme DcpS is a member of the HIT family of pyrophosphatases."
Liu H. , Rodgers N.D. , Jiao X. , Kiledjian M.
EMBO J.21:4699-4708(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];FUNCTION;IDENTIFICATION BY MASS SPECTROMETRY;MUTAGENESIS OF HIS-277;SUBUNIT
3.

"Coordinate expression of NADPH-dependent flavin reductase, Fre-1, and Hint-related 7meGMP-directed hydrolase, DCS-1."
Kwasnicka D.A. , Krakowiak A. , Thacker C. , Brenner C. , Vincent S.R.
J. Biol. Chem.278:39051-39058(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];FUNCTION;SUBCELLULAR LOCATION;TISSUE SPECIFICITY
tissue: Placenta.
4.

"Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells."
Zhang Q.-H. , Ye M. , Wu X.-Y. , Ren S.-X. , Zhao M. , Zhao C.-J. , Fu G. , Shen Y. , Fan H.-Y. , Lu G. , Zhong M. , Xu X.-R. , Han Z.-G. , Zhang J.-W. , Tao J. , Huang Q.-H. , Zhou J. , Hu G.-X. , more...
Genome Res.10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Umbilical cord blood.
5.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANT GLU-73
tissue: Bone marrow.
6.

Bienvenut W.V.
Submitted (2010-01) to the UniProtKB

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 2-11; 129-138 AND 243-255;CLEAVAGE OF INITIATOR METHIONINE;ACETYLATION AT ALA-2;IDENTIFICATION BY MASS SPECTROMETRY
tissue: Ovarian carcinoma.
7.

"Functional link between the mammalian exosome and mRNA decapping."
Wang Z. , Kiledjian M.
Cell107:751-762(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH EXOSOME PROTEINS
8.

"DcpS can act in the 5'-3' mRNA decay pathway in addition to the 3'-5' pathway."
van Dijk E. , Le Hir H. , Seraphin B.
Proc. Natl. Acad. Sci. U.S.A.100:12081-12086(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
9.

"Functional analysis of mRNA scavenger decapping enzymes."
Liu S.-W. , Jiao X. , Liu H. , Gu M. , Lima C.D. , Kiledjian M.
RNA10:1412-1422(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;CATALYTIC ACTIVITY;SUBSTRATE SPECIFICITY;DOMAIN;SUBCELLULAR LOCATION;MUTAGENESIS OF HIS-277
10.

"Nematode m7GpppG and m3(2,2,7)GpppG decapping: activities in Ascaris embryos and characterization of C. elegans scavenger DcpS."
Cohen L.S. , Mikhli C. , Friedman C. , Jankowska-Anyszka M. , Stepinski J. , Darzynkiewicz E. , Davis R.E.
RNA10:1609-1624(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;CATALYTIC ACTIVITY;SUBSTRATE SPECIFICITY
11.

"Role of a novel dual flavin reductase (NR1) and an associated histidine triad protein (DCS-1) in menadione-induced cytotoxicity."
Kwasnicka-Crawford D.A. , Vincent S.R.
Biochem. Biophys. Res. Commun.336:565-571(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN CYTOTOXICITY INHIBITION;INDUCTION;INTERACTION WITH NDOR1
12.

"DcpS scavenger decapping enzyme can modulate pre-mRNA splicing."
Shen V. , Liu H. , Liu S.W. , Jiao X. , Kiledjian M.
RNA14:1132-1142(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN SPLICING;MUTAGENESIS OF 10-LYS--ARG-13; LEU-148 AND LEU-150;SUBCELLULAR LOCATION
13.

"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Gauci S. , Helbig A.O. , Slijper M. , Krijgsveld J. , Heck A.J. , Mohammed S.
Anal. Chem.81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
14.

"Proteomic approach to the identification of novel delta-lactoferrin target genes: Characterization of DcpS, an mRNA scavenger decapping enzyme."
Mariller C. , Hardiville S. , Hoedt E. , Benaissa M. , Mazurier J. , Pierce A.
Biochimie91:109-122(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INDUCTION;IDENTIFICATION BY MASS SPECTROMETRY
15.

"Lysine acetylation targets protein complexes and co-regulates major cellular functions."
Choudhary C. , Kumar C. , Gnad F. , Nielsen M.L. , Rehman M. , Walther T.C. , Olsen J.V. , Mann M.
Science325:834-840(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-138 AND LYS-142;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
16.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
17.

"7-Methylguanosine diphosphate (m(7)GDP) is not hydrolyzed but strongly bound by decapping scavenger (dcpS) enzymes and potently inhibits their activity."
Wypijewska A. , Bojarska E. , Lukaszewicz M. , Stepinski J. , Jemielity J. , Davis R.E. , Darzynkiewicz E.
Biochemistry51:8003-8013(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;CATALYTIC ACTIVITY;SUBSTRATE SPECIFICITY;ENZYME REGULATION
18.

"Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
Bienvenut W.V. , Sumpton D. , Martinez A. , Lilla S. , Espagne C. , Meinnel T. , Giglione C.
Mol. Cell. Proteomics11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
19.

"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Van Damme P. , Lasa M. , Polevoda B. , Gazquez C. , Elosegui-Artola A. , Kim D.S. , De Juan-Pardo E. , Demeyer K. , Hole K. , Larrea E. , Timmerman E. , Prieto J. , Arnesen T. , Sherman F. , Gevaert K. , Aldabe R.
Proc. Natl. Acad. Sci. U.S.A.109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
20.

"Insights into the structure, mechanism, and regulation of scavenger mRNA decapping activity."
Gu M. , Fabrega C. , Liu S.-W. , Liu H. , Kiledjian M. , Lima C.D.
Mol. Cell14:67-80(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF MUTANT ASN-277 IN COMPLEX WITH SUBSTRATE;SUBUNIT;MUTAGENESIS OF ARG-58; ILE-61; PHE-63; ILE-83; GLU-85; PHE-108; ASN-110; TYR-113; LYS-128; LYS-138; ARG-145; GLN-146; TRP-175; GLU-185; PRO-204; ASP-205; LEU-206; LYS-207; TYR-217; HIS-268; SER-272; HIS-277; HIS-279; ARG-294 AND ARG-322
21.

"Crystal structures of human DcpS in ligand-free and m7GDP-bound forms suggest a dynamic mechanism for scavenger mRNA decapping."
Chen N. , Walsh M.A. , Liu Y. , Parker R. , Song H.
J. Mol. Biol.347:707-718(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) IN COMPLEX WITH SUBSTRATE;FUNCTION;SUBUNIT;MUTAGENESIS OF TYR-273
22.

"DcpS as a therapeutic target for spinal muscular atrophy."
Singh J. , Salcius M. , Liu S.W. , Staker B.L. , Mishra R. , Thurmond J. , Michaud G. , Mattoon D.R. , Printen J. , Christensen J. , Bjornsson J.M. , Pollok B.A. , Kiledjian M. , Stewart L. , Jarecki J. , Gurney M.E.
ACS Chem. Biol.3:711-722(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 38-337 IN COMPLEX WITH SUBSTRATE ANALOGS;CATALYTIC ACTIVITY;ENZYME REGULATION

Product Feedback Wall

* Email:
*Comments: