Ddx1 ELISA Kit for Rat(Rattus norvegicus) | EIAab.comDdx1 ELISA Kit for Rat(Rattus norvegicus)

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Ddx1 (Gene name),

ATP-dependent RNA helicase DDX1 (Protein name ), DDX1_RAT from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Ddx1;

Protein name:

ATP-dependent RNA helicase DDX1;

Alternative:

DEAD box protein 1;

Organism:

Rat (Rattus norvegicus).

General Annotation

Sub Unit:

Interacts with PHF5A (via C-terminus). Interacts with MBNL1. Interacts with CSTF2. Interacts with HNRNPK. Interacts with ATM. Interacts with RELA (via C-terminal). Component of the tRNA-splicing ligase complex.

Function:

Acts as an ATP-dependent RNA helicase, able to unwind both RNA-RNA and RNA-DNA duplexes. Possesses 5' single-stranded RNA overhang nuclease activity. Possesses ATPase activity on various RNA, but not DNA polynucleotides. May play a role in RNA clearance at DNA double-strand breaks (DSBs), thereby facilitating the template-guided repair of transcriptionally active regions of the genome. Together with RELA, acts as a coactivator to enhance NF-kappa-B-mediated transcriptional activation. Acts as a positive transcriptional regulator of cyclin CCND2 expression. Binds to the cyclin CCND2 promoter region. Associates with chromatin at the NF-kappa-B promoter region via association with RELA. Binds to poly(A) RNA. May be involved in 3'-end cleavage and polyadenylation of pre-mRNAs.

Subcellular Location:

Nucleus Cytoplasm Cytoplasmic granule Localized with MBNL1, TIAL1 and YBX1 in stress granules upon stress. Localized with CSTF2 in cleavage bodies. Forms large aggregates called DDX1 bodies. Relocalized into multiple foci (IR-induced foci or IRIF) after IR treatment, a process that depends on the presence of chromosomal DNA and/or RNA-DNA duplexes. Relocalized at sites of DNA double-strand breaks (DSBs) in an ATM-dependent manner after IR treatment. Colocalized with RELA in the nucleus upon TNF-alpha induction.

Protein Attributes:

Sequence length:

740

Sequence:

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740:

YKGHVDILAP | TVQELAALEK | EAQTSFLHLG | YLPNQLFRTF |

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

Rn.65536

Pfam:

PF00270

KEGG:

rno:84474

String:

Q641Y8

STRING:

10116.ENSRNOP00000009100

Uniprot:

Q641Y8

FOR

ELISA Kit for Rat ATP-dependent RNA helicase DDX1

CLIA Kit for Rat ATP-dependent RNA helicase DDX1

Polyclonal Antibody for Rat ATP-dependent RNA helicase DDX1

Monoclonal Antibody for Rat ATP-dependent RNA helicase DDX1

Protein for Rat ATP-dependent RNA helicase DDX1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Testis.

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