Ddx58 ELISA Kit for Mouse(Mus musculus) | EIAab.comDdx58 ELISA Kit for Mouse(Mus musculus)

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Ddx58 (Gene name),

Probable ATP-dependent RNA helicase DDX58 (Protein name ), DDX58_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

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Gene name:

Ddx58;

Protein name:

Probable ATP-dependent RNA helicase DDX58;

Alternative:

Retinoic acid-inducible gene 1 protein(RIG-1);DEAD box protein 58;Retinoic acid-inducible gene I protein(RIG-I);Retinoic acid-inducible gene I protein(RIG-I);

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Monomer; maintained as a monomer in an autoinhibited state. Upon viral dsRNA binding and conformation shift, homomultimerizes and interacts with MAVS. Interacts with DHX58/LGP2, IKBKE, TBK1 and TMEM173/STING (By similarity). Interacts (via CARD domain) with TRIM25 (via SPRY domain). Interacts with CYLD. Interacts with RNF135 (By similarity). Interacts with CYLD. Interacts with NLRC5; blocks the interaction of MAVS to DDX58. Interacts with SRC.

Function:

Involved in innate immune defense against viruses. Upon interaction with intracellular dsRNA produced during viral replication, triggers a transduction cascade involving MAVS/IPS1, which results in the activation of NF-kappa-B, IRF3 and IRF7 and the induction of the expression of antiviral cytokines such as IFN-beta and RANTES (CCL5). Detects dsRNA produced from non-self dsDNA by RNA polymerase III. Essential for the production of interferons in response to RNA viruses including paramyxoviruses, and possibly other negative strand RNA viruses.

Subcellular Location:

Cytoplasm Colocalized with TRIM25 at cytoplasmic perinuclear bodies.

Protein Attributes:

Sequence length:

926

Sequence:

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926:

GVQNRHSKWK | DFHFERIQFD | PAEMSV

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

KEGG:

mmu:230073

Pfam:

PF00270

UniGene:

Mm.86382

String:

Q6Q899

SMR:

Q6Q899

Uniprot:

Q6Q899

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ELISA Kit for Mouse Probable ATP-dependent RNA helicase DDX58

Cat.:

E16293p

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96T

ELISA Kit for Mouse Probable ATP-dependent RNA helicase DDX58

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E16293m

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96T

ELISA Kit for Mouse Probable ATP-dependent RNA helicase DDX58

Cat.:

E16293h

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96T

CLIA Kit for Mouse Probable ATP-dependent RNA helicase DDX58

Cat.:

U16293h

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96T

CLIA Kit for Mouse Probable ATP-dependent RNA helicase DDX58

Cat.:

U16293p

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Mouse Probable ATP-dependent RNA helicase DDX58

Cat.:

U16293m

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MSDS:

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96T

Polyclonal Antibody for Mouse Probable ATP-dependent RNA helicase DDX58

Cat.:

P16293Rb-h

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40ug/0.2ml

Polyclonal Antibody for Mouse Probable ATP-dependent RNA helicase DDX58

Cat.:

P16293Rb-m

Price:

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Packing:

40ug/0.2ml

Polyclonal Antibody for Mouse Probable ATP-dependent RNA helicase DDX58

Monoclonal Antibody for Mouse Probable ATP-dependent RNA helicase DDX58

Protein for Mouse Probable ATP-dependent RNA helicase DDX58

R&D Technical Data

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Precision

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Recovery

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Linearity

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References

1.

Wei J. , Gu J.
Submitted (2004-02) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
2.

"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M. , Goodstadt L. , Hillier L.W. , Zody M.C. , Goldstein S. , She X. , Bult C.J. , Agarwala R. , Cherry J.L. , DiCuccio M. , Hlavina W. , Kapustin Y. , Meric P. , Maglott D. , Birtle Z. , Marques A.C. , Graves T. , Zhou S. , more...
PLoS Biol.7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
strain: C57BL/6J.
3.

Mural R.J. , Adams M.D. , Myers E.W. , Smith H.O. , Venter J.C.
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
4.

"The transcriptional landscape of the mammalian genome."
Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2; 3 AND 4)
strain: C57BL/6J.
tissue: Olfactory bulb.
5.

"Cell type-specific involvement of RIG-I in antiviral response."
Kato H. , Sato S. , Yoneyama M. , Yamamoto M. , Uematsu S. , Matsui K. , Tsujimura T. , Takeda K. , Fujita T. , Takeuchi O. , Akira S.
Immunity23:19-28(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
6.

"Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses."
Kato H. , Takeuchi O. , Sato S. , Yoneyama M. , Yamamoto M. , Matsui K. , Uematsu S. , Jung A. , Kawai T. , Ishii K.J. , Yamaguchi O. , Otsu K. , Tsujimura T. , Koh C.S. , Reis e Sousa C. , Matsuura Y. , Fujita T. , Akira S.
Nature441:101-105(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DISRUPTION PHENOTYPE
7.

"Distinct RIG-I and MDA5 signaling by RNA viruses in innate immunity."
Loo Y.M. , Fornek J. , Crochet N. , Bajwa G. , Perwitasari O. , Martinez-Sobrido L. , Akira S. , Gill M.A. , Garcia-Sastre A. , Katze M.G. , Gale M. Jr.
J. Virol.82:335-345(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
8.

"RNA polymerase III detects cytosolic DNA and induces type I interferons through the RIG-I pathway."
Chiu Y.-H. , Macmillan J.B. , Chen Z.J.
Cell138:576-591(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
9.

"Recognition of 5' triphosphate by RIG-I helicase requires short blunt double-stranded RNA as contained in panhandle of negative-strand virus."
Schlee M. , Roth A. , Hornung V. , Hagmann C.A. , Wimmenauer V. , Barchet W. , Coch C. , Janke M. , Mihailovic A. , Wardle G. , Juranek S. , Kato H. , Kawai T. , Poeck H. , Fitzgerald K.A. , Takeuchi O. , Akira S. , Tuschl T. , more...
Immunity31:25-34(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
10.

"RIG-I-dependent sensing of poly(dA:dT) through the induction of an RNA polymerase III-transcribed RNA intermediate."
Ablasser A. , Bauernfeind F. , Hartmann G. , Latz E. , Fitzgerald K.A. , Hornung V.
Nat. Immunol.10:1065-1072(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
11.

"Function and regulation of retinoic acid-inducible gene-I."
Matsumiya T. , Stafforini D.M.
Crit. Rev. Immunol.30:489-513(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON FUNCTION
12.

"Immune signaling by RIG-I-like receptors."
Loo Y.M. , Gale M. Jr.
Immunity34:680-692(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON FUNCTION
13.

"RIG-I-like receptors: cytoplasmic sensors for non-self RNA."
Kato H. , Takahasi K. , Fujita T.
Immunol. Rev.243:91-98(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON FUNCTION
14.

"Retinoic acid-inducible gene-I-like receptors."
Onoguchi K. , Yoneyama M. , Fujita T.
J. Interferon Cytokine Res.31:27-31(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON FUNCTION
15.

"Sensing of viral nucleic acids by RIG-I: from translocation to translation."
Schmidt A. , Rothenfusser S. , Hopfner K.P.
Eur. J. Cell Biol.91:78-85(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON FUNCTION

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