DDX5 ELISA Kit for Human(Homo sapiens) | EIAab.comDDX5 ELISA Kit for Human(Homo sapiens)

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DDX5 (Gene name),

Probable ATP-dependent RNA helicase DDX5 (Protein name ), DDX5_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

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Gene name:

DDX5(G17P1;HELR;HLR1);

Protein name:

Probable ATP-dependent RNA helicase DDX5;

Alternative:

RNA helicase p68;DEAD box protein 5;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Identified in the spliceosome C complex. Interacts with RBM4; the interaction occurs in a RNA-independent manner. Interacts with EIF2C1 and EIF2C2.

Function:

Involved in the alternative regulation of pre-mRNA splicing; its RNA helicase activity is necessary for increasing tau exon 10 inclusion and occurs in a RBM4-dependent manner. Binds to the tau pre-mRNA in the stem-loop region downstream of exon 10. The rate of ATP hydrolysis is highly stimulated by single-stranded RNA.

Subcellular Location:

Nucleus nucleolus

Protein Attributes:

Sequence length:

614

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

614:

APMIGYPMPT | GYSQ

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

String:

P17844

Pfam:

PF00270

MIM:

180630

STRING:

9606.ENSP00000225792

UniGene:

Hs.279806

SMR:

P17844

KEGG:

hsa:1655

Uniprot:

P17844

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ELISA Kit for Human Probable ATP-dependent RNA helicase DDX5

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E2641h

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96T

ELISA Kit for Human Probable ATP-dependent RNA helicase DDX5

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E2641m

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96T

CLIA Kit for Human Probable ATP-dependent RNA helicase DDX5

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U2641h

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96T

CLIA Kit for Human Probable ATP-dependent RNA helicase DDX5

Cat.:

U2641m

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96T

Polyclonal Antibody for Human Probable ATP-dependent RNA helicase DDX5

Cat.:

P2641Rb-m

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40ug/0.2ml

Polyclonal Antibody for Human Probable ATP-dependent RNA helicase DDX5

Cat.:

P2641Rb-h

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Packing:

40ug/0.2ml

Monoclonal Antibody for Human Probable ATP-dependent RNA helicase DDX5

Protein for Human Probable ATP-dependent RNA helicase DDX5

R&D Technical Data

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Precision

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Recovery

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Linearity

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References

1.

"Complete cDNA sequence of the human p68 protein."
Hloch P. , Stahl H.
Nucleic Acids Res.18:3045-3045(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
2.

"p68 RNA helicase: identification of a nucleolar form and cloning of related genes containing a conserved intron in yeasts."
Iggo R.D. , Jamieson D.J. , McNeill S.A. , Southgate J. , McPheat J. , Lane D.P.
Mol. Cell. Biol.11:1326-1333(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];SUBCELLULAR LOCATION
3.

"Structure and expression of the human p68 RNA helicase gene."
Roessler O.G. , Hloch P. , Schutz N. , Weitzenegger T. , Stahl H.
Nucleic Acids Res.28:932-939(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
4.

"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N. , Chen X. , Rolfs A. , Halleck A. , Hines L. , Eisenstein S. , Koundinya M. , Raphael J. , Moreira D. , Kelley T. , LaBaer J. , Lin Y. , Phelan M. , Farmer A.
Submitted (2003-05) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
5.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
tissue: Brain.
6.

"Human protein factory for converting the transcriptome into an in vitro-expressed proteome."
Goshima N. , Kawamura Y. , Fukumoto A. , Miura A. , Honma R. , Satoh R. , Wakamatsu A. , Yamamoto J. , Kimura K. , Nishikawa T. , Andoh T. , Iida Y. , Ishikawa K. , Ito E. , Kagawa N. , Kaminaga C. , Kanehori K. , Kawakami B. , more...
Nat. Methods5:1011-1017(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
7.

"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
Zody M.C. , Garber M. , Adams D.J. , Sharpe T. , Harrow J. , Lupski J.R. , Nicholson C. , Searle S.M. , Wilming L. , Young S.K. , Abouelleil A. , Allen N.R. , Bi W. , Bloom T. , Borowsky M.L. , Bugalter B.E. , Butler J. , Chang J.L. , more...
Nature440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
8.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-09) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
9.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue: Muscle.
10.

"Nuclear protein with sequence homology to translation initiation factor eIF-4A."
Ford M.J. , Anton I.A. , Lane D.P.
Nature332:736-738(1988) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 21-614 (ISOFORM 1)
11.

"Molecular organization of the murine p68 RNA helicase gene promotor region."
Petry P. , Bammer S. , Heinlein U.A.O.
Submitted (1998-09) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 53-163
12.

"Purification and identification of p68 RNA helicase acting as a transcriptional coactivator specific for the activation function 1 of human estrogen receptor alpha."
Endoh H. , Maruyama K. , Masuhiro Y. , Kobayashi Y. , Goto M. , Tai H. , Yanagisawa J. , Metzger D. , Hashimoto S. , Kato S.
Mol. Cell. Biol.19:5363-5372(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION AS TRANSCRIPTIONAL COACTIVATOR;INTERACTION WITH ESR1;MUTAGENESIS OF LYS-144
13.

"The nuclear DEAD box RNA helicase p68 interacts with the nucleolar protein fibrillarin and colocalizes specifically in nascent nucleoli during telophase."
Nicol S.M. , Causevic M. , Prescott A.R. , Fuller-Pace F.V.
Exp. Cell Res.257:272-280(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH FBL;SUBCELLULAR LOCATION
14.

"A subfamily of RNA-binding DEAD-box proteins acts as an estrogen receptor alpha coactivator through the N-terminal activation domain (AF-1) with an RNA coactivator, SRA."
Watanabe M. , Yanagisawa J. , Kitagawa H. , Takeyama K. , Ogawa S. , Arao Y. , Suzawa M. , Kobayashi Y. , Yano T. , Yoshikawa H. , Masuhiro Y. , Kato S.
EMBO J.20:1341-1352(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION AS TRANSCRIPTIONAL COACTIVATOR;INTERACTION WITH ESR1; NCOA1; NCOA2 AND NCOA3
15.

"Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis."
Jurica M.S. , Licklider L.J. , Gygi S.P. , Grigorieff N. , Moore M.J.
RNA8:426-439(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY;IDENTIFICATION IN THE SPLICEOSOMAL C COMPLEX
16.

"The highly related DEAD box RNA helicases p68 and p72 exist as heterodimers in cells."
Ogilvie V.C. , Wilson B.J. , Nicol S.M. , Morrice N.A. , Saunders L.R. , Barber G.N. , Fuller-Pace F.V.
Nucleic Acids Res.31:1470-1480(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SELF-ASSOCIATION;INTERACTION WITH DDX17
17.

"Synergism between p68 RNA helicase and the transcriptional coactivators CBP and p300."
Rossow K.L. , Janknecht R.
Oncogene22:151-156(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION AS TRANSCRIPTIONAL COACTIVATOR;INTERACTION WITH EP300; CREBBP AND POLR2A
18.

"The p68 and p72 DEAD box RNA helicases interact with HDAC1 and repress transcription in a promoter-specific manner."
Wilson B.J. , Bates G.J. , Nicol S.M. , Gregory D.J. , Perkins N.D. , Fuller-Pace F.V.
BMC Mol. Biol.5:11-11(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN TRANSCRIPTIONAL REPRESSION;INTERACTION WITH HDAC1
19.

"The DEAD box protein p68: a novel transcriptional coactivator of the p53 tumour suppressor."
Bates G.J. , Nicol S.M. , Wilson B.J. , Jacobs A.M. , Bourdon J.C. , Wardrop J. , Gregory D.J. , Lane D.P. , Perkins N.D. , Fuller-Pace F.V.
EMBO J.24:543-553(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION AS TRANSCRIPTIONAL COACTIVATOR;INTERACTION WITH TP53
20.

"Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."
Rush J. , Moritz A. , Lee K.A. , Guo A. , Goss V.L. , Spek E.J. , Zhang H. , Zha X.-M. , Polakiewicz R.D. , Comb M.J.
Nat. Biotechnol.23:94-101(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-297;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
21.

"The RNA helicases p68/p72 and the noncoding RNA SRA are coregulators of MyoD and skeletal muscle differentiation."
Caretti G. , Schiltz R.L. , Dilworth F.J. , Di Padova M. , Zhao P. , Ogryzko V. , Fuller-Pace F.V. , Hoffman E.P. , Tapscott S.J. , Sartorelli V.
Dev. Cell11:547-560(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH MYOD1;MUTAGENESIS OF LYS-144
22.

"Proteomic and functional analysis of Argonaute-containing mRNA-protein complexes in human cells."
Hoeck J. , Weinmann L. , Ender C. , Ruedel S. , Kremmer E. , Raabe M. , Urlaub H. , Meister G.
EMBO Rep.8:1052-1060(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH AGO1 AND AGO2
23.

"SUMO modification of the DEAD box protein p68 modulates its transcriptional activity and promotes its interaction with HDAC1."
Jacobs A.M. , Nicol S.M. , Hislop R.G. , Jaffray E.G. , Hay R.T. , Fuller-Pace F.V.
Oncogene26:5866-5876(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUMOYLATION AT LYS-53;INTERACTION WITH HDAC1 AND PIAS1;MUTAGENESIS OF LYS-53 AND GLU-55
24.

"The RNA helicase p68 is a novel androgen receptor coactivator involved in splicing and is overexpressed in prostate cancer."
Clark E.L. , Coulson A. , Dalgliesh C. , Rajan P. , Nicol S.M. , Fleming S. , Heer R. , Gaughan L. , Leung H.Y. , Elliott D.J. , Fuller-Pace F.V. , Robson C.N.
Cancer Res.68:7938-7946(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION AS TRANSCRIPTIONAL COACTIVATOR;INTERACTION WITH AR
25.

"p68 (Ddx5) interacts with Runx2 and regulates osteoblast differentiation."
Jensen E.D. , Niu L. , Caretti G. , Nicol S.M. , Teplyuk N. , Stein G.S. , Sartorelli V. , van Wijnen A.J. , Fuller-Pace F.V. , Westendorf J.J.
J. Cell. Biochem.103:1438-1451(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH RUNX2
26.

"A quantitative atlas of mitotic phosphorylation."
Dephoure N. , Zhou C. , Villen J. , Beausoleil S.A. , Bakalarski C.E. , Elledge S.J. , Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A.105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
27.

"The DEAD-box protein p72 regulates ERalpha-/oestrogen-dependent transcription and cell growth, and is associated with improved survival in ERalpha-positive breast cancer."
Wortham N.C. , Ahamed E. , Nicol S.M. , Thomas R.S. , Periyasamy M. , Jiang J. , Ochocka A.M. , Shousha S. , Huson L. , Bray S.E. , Coombes R.C. , Ali S. , Fuller-Pace F.V.
Oncogene28:4053-4064(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH ESR1
28.

"Lysine acetylation targets protein complexes and co-regulates major cellular functions."
Choudhary C. , Kumar C. , Gnad F. , Nielsen M.L. , Rehman M. , Walther T.C. , Olsen J.V. , Mann M.
Science325:834-840(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-32; LYS-33 AND LYS-40;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
29.

"Sumoylation of p68 and p72 RNA helicases affects protein stability and transactivation potential."
Mooney S.M. , Grande J.P. , Salisbury J.L. , Janknecht R.
Biochemistry49:1-10(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUMOYLATION AT LYS-53;MUTAGENESIS OF LYS-53;POLYUBIQUITINATION
30.

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-480;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
31.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
32.

"RNA helicase p68 (DDX5) regulates tau exon 10 splicing by modulating a stem-loop structure at the 5' splice site."
Kar A. , Fushimi K. , Zhou X. , Ray P. , Shi C. , Chen X. , Liu Z. , Chen S. , Wu J.Y.
Mol. Cell. Biol.31:1812-1821(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH RBM4;MUTAGENESIS OF ARG-403;RNA-BINDING
33.

"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Rigbolt K.T. , Prokhorova T.A. , Akimov V. , Henningsen J. , Johansen P.T. , Kratchmarova I. , Kassem M. , Mann M. , Olsen J.V. , Blagoev B.
Sci. Signal.4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-480;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
34.

"Comparative structural analysis of human DEAD-box RNA helicases."
Schutz P. , Karlberg T. , van den Berg S. , Collins R. , Lehtio L. , Hogbom M. , Holmberg-Schiavone L. , Tempel W. , Park H.W. , Hammarstrom M. , Moche M. , Thorsell A.G. , Schuler H.
PLoS ONE5:E12791-E12791(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS) OF 68-307 IN COMPLEX WITH ADP

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