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Index > Protein center > Deaf1(Gene name) > Mouse
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  • Deaf1 (Gene name),
  • Deformed epidermal autoregulatory factor 1 homolog (Protein name ),  DEAF1_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    Deaf1;
    Protein name:
    Deformed epidermal autoregulatory factor 1 homolog;
    Alternative:
    Nuclear DEAF-1-related transcriptional regulator(NUDR);
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Homodimer (Probable). Isoform 1 and isoform 2 may form a heterodimer. Binds to LMO4 (via its C-terminus), LMO2 and CLIM2. May interact with the corepressor NCOR.
    Function:
    Transcription factor that binds to sequence with multiple copies of 5'-TTC[CG]G-3' present in its own promoter and that of the HNRPA2B1 gene. Down-regulates transcription of these genes. Binds to the retinoic acid response element (RARE) 5'-AGGGTTCACCGAAAGTTCA-3'. Activates the proenkephalin gene independently of promoter binding, probably through protein-protein interaction (By similarity). Regulates epithelial cell proliferation and side-branching in the mammary gland. Required for neural tube closure and skeletal patterning. Controls the expression of peripheral tissue antigens in pancreatic lymph nodes. Isoform 1 displays greater transcriptional activity than isoform 2. Isoform 2 may inhibit transcriptional activity of isoform 1 by interacting with it and retaining it in the cytoplasm.
    Subcellular Location:
    Isoform 2 Cytoplasm Nucleus Displays some nuclear localization when expressed with isoform 1, suggesting that it may heterodimerize with isoform 1 and shuttle to the nucleus using the nuclear localization signal of isoform 1.
    Protein Attributes:
    Sequence length:
    566
    Sequence:
    50:
    MEDSDSAAKQ | LGLAEAAAVA | AAAAVAAAAA | AAAESEAEEP | VLSRDEDSEE | 
    100:
    DADSEAERET | RRVTAVAVMA | AESGHMDMGT | EALPSPDEAA | AAAAAFAEVT | 
    150:
    TVTVANVGSS | ADNVFTTSVA | NAASISGHVL | SGRTALQIGD | SLNTEKATLI | 
    200:
    VVHTDGSIVE | TTGLKGPAAP | LTPGPQSPPT | PLAPGQEKGG | TKYNWDPSVY | 
    250:
    DSELPVRCRN | ISGTLYKSRL | GSGGRGRCIK | QGENWYSPTE | FEAMAGRASS | 
    300:
    KDWKRSIRYA | GRPLQCLIQD | GILNPHAASC | TCAACCDDMT | LSGPVRLFVP | 
    350:
    YKRRKKENEL | PTTPVKKDSP | KNITLLPATA | ATTFTVTPSG | QITTSGALTF | 
    400:
    DRASTVEATA | VISESPAQGD | VFAGATVQEA | GVQPPCRVGH | PEPHYPGYQD | 
    450:
    SCQIAPFPEA | ALPTSHPKIV | LTSLPALAVP | PSTPTKAVSP | TVVSGLEMSE | 
    500:
    HRSWLYLEEM | VNSLLNTAQQ | LKTLFEQAKQ | ASSCREAAVT | QARMQVDTER | 
    550:
    KEQSCVNCGR | EAMSECTGCH | KVNYCSTFCQ | RKDWKDHQHV | CGQSASVTVQ | 
    566:
    ADDVHVEESV | IEKVAV
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    SMR:
    UniGene:
    String:
    Pfam:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse Deformed epidermal autoregulatory factor 1 homolog
    ELISA Kit for Mouse Deformed epidermal autoregulatory factor 1 homolog
    ELISA Kit for Mouse Deformed epidermal autoregulatory factor 1 homolog
    CLIA Kit for Mouse Deformed epidermal autoregulatory factor 1 homolog
    CLIA Kit for Mouse Deformed epidermal autoregulatory factor 1 homolog
    CLIA Kit for Mouse Deformed epidermal autoregulatory factor 1 homolog
    Polyclonal Antibody for Mouse Deformed epidermal autoregulatory factor 1 homolog
    Polyclonal Antibody for Mouse Deformed epidermal autoregulatory factor 1 homolog
    Polyclonal Antibody for Mouse Deformed epidermal autoregulatory factor 1 homolog
    Monoclonal Antibody for Mouse Deformed epidermal autoregulatory factor 1 homolog
    Monoclonal Antibody for Mouse Deformed epidermal autoregulatory factor 1 homolog
    Monoclonal Antibody for Mouse Deformed epidermal autoregulatory factor 1 homolog
    Protein for Mouse Deformed epidermal autoregulatory factor 1 homolog
    Protein for Mouse Deformed epidermal autoregulatory factor 1 homolog
    Protein for Mouse Deformed epidermal autoregulatory factor 1 homolog

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    Precision
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    Linearity
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    References
    1. 1.
      "Mouse deformed epidermal autoregulatory factor 1 recruits a LIM domain factor, LMO-4, and CLIM coregulators."
      Sugihara T.M. , Bach I. , Kioussi C. , Rosenfeld M.G. , Andersen B.
      Proc. Natl. Acad. Sci. U.S.A.95:15418-15423(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);INTERACTION WITH CLIM2; LMO2 AND LMO4;TISSUE SPECIFICITY
      tissue: Pituitary.
      tissue: Skin.
    2. 2.
      "Deaf1 isoforms control the expression of genes encoding peripheral tissue antigens in the pancreatic lymph nodes during type 1 diabetes."
      Yip L. , Su L. , Sheng D. , Chang P. , Atkinson M. , Czesak M. , Albert P.R. , Collier A.R. , Turley S.J. , Fathman C.G. , Creusot R.J.
      Nat. Immunol.10:1026-1033(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2);FUNCTION;SUBCELLULAR LOCATION;DEVELOPMENTAL STAGE
      strain: NOD.
      tissue: Pancreas.
    3. 3.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      strain: C57BL/6J.
      tissue: Kidney.
    4. 4.
      Mural R.J. , Adams M.D. , Myers E.W. , Smith H.O. , Venter J.C.
      Submitted (2005-07) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 5.
      "Defective neural tube closure and anteroposterior patterning in mice lacking the LIM protein LMO4 or its interacting partner Deaf-1."
      Hahm K. , Sum E.Y. , Fujiwara Y. , Lindeman G.J. , Visvader J.E. , Orkin S.H.
      Mol. Cell. Biol.24:2074-2082(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DISRUPTION PHENOTYPE
    6. 6.
      "Deaf-1 regulates epithelial cell proliferation and side-branching in the mammary gland."
      Barker H.E. , Smyth G.K. , Wettenhall J. , Ward T.A. , Bath M.L. , Lindeman G.J. , Visvader J.E.
      BMC Dev. Biol.8:94-94(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DEVELOPMENTAL STAGE
    7. 7.
      "Contribution of DEAF1 structural domains to the interaction with the breast cancer oncogene LMO4."
      Cubeddu L. , Joseph S. , Richard D.J. , Matthews J.M.
      PLoS ONE7:E39218-E39218(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH LMO4;SUBUNIT;SUBCELLULAR LOCATION;MUTAGENESIS OF LYS-305
    8. 8.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DISRUPTION PHENOTYPE
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