Protein name:
Deformed epidermal autoregulatory factor 1 homolog ;
Alternative:
Nuclear DEAF-1-related transcriptional regulator (NUDR) ;
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Homodimer (Probable). Isoform 1 and isoform 2 may form a heterodimer. Binds to LMO4 (via its C-terminus), LMO2 and CLIM2. May interact with the corepressor NCOR.
Function:
Transcription factor that binds to sequence with multiple copies of 5'-TTC[CG]G-3' present in its own promoter and that of the HNRPA2B1 gene. Down-regulates transcription of these genes. Binds to the retinoic acid response element (RARE) 5'-AGGGTTCACCGAAAGTTCA-3'. Activates the proenkephalin gene independently of promoter binding, probably through protein-protein interaction (By similarity). Regulates epithelial cell proliferation and side-branching in the mammary gland. Required for neural tube closure and skeletal patterning. Controls the expression of peripheral tissue antigens in pancreatic lymph nodes. Isoform 1 displays greater transcriptional activity than isoform 2. Isoform 2 may inhibit transcriptional activity of isoform 1 by interacting with it and retaining it in the cytoplasm.
Subcellular Location:
Isoform 2
Cytoplasm
Nucleus
Displays some nuclear localization when expressed with isoform 1, suggesting that it may heterodimerize with isoform 1 and shuttle to the nucleus using the nuclear localization signal of isoform 1.
Protein Attributes:
50:
MEDSDSAAKQ | LGLAEAAAVA | AAAAVAAAAA | AAAESEAEEP | VLSRDEDSEE |
100:
DADSEAERET | RRVTAVAVMA | AESGHMDMGT | EALPSPDEAA | AAAAAFAEVT |
150:
TVTVANVGSS | ADNVFTTSVA | NAASISGHVL | SGRTALQIGD | SLNTEKATLI |
200:
VVHTDGSIVE | TTGLKGPAAP | LTPGPQSPPT | PLAPGQEKGG | TKYNWDPSVY |
250:
DSELPVRCRN | ISGTLYKSRL | GSGGRGRCIK | QGENWYSPTE | FEAMAGRASS |
300:
KDWKRSIRYA | GRPLQCLIQD | GILNPHAASC | TCAACCDDMT | LSGPVRLFVP |
350:
YKRRKKENEL | PTTPVKKDSP | KNITLLPATA | ATTFTVTPSG | QITTSGALTF |
400:
DRASTVEATA | VISESPAQGD | VFAGATVQEA | GVQPPCRVGH | PEPHYPGYQD |
450:
SCQIAPFPEA | ALPTSHPKIV | LTSLPALAVP | PSTPTKAVSP | TVVSGLEMSE |
500:
HRSWLYLEEM | VNSLLNTAQQ | LKTLFEQAKQ | ASSCREAAVT | QARMQVDTER |
550:
KEQSCVNCGR | EAMSECTGCH | KVNYCSTFCQ | RKDWKDHQHV | CGQSASVTVQ |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Rat
Human
Mouse
ELISA Kit for Mouse Deformed epidermal autoregulatory factor 1 homolog
ELISA Kit for Mouse Deformed epidermal autoregulatory factor 1 homolog
ELISA Kit for Mouse Deformed epidermal autoregulatory factor 1 homolog
CLIA Kit for Mouse Deformed epidermal autoregulatory factor 1 homolog
CLIA Kit for Mouse Deformed epidermal autoregulatory factor 1 homolog
CLIA Kit for Mouse Deformed epidermal autoregulatory factor 1 homolog
Polyclonal Antibody for Mouse Deformed epidermal autoregulatory factor 1 homolog
Polyclonal Antibody for Mouse Deformed epidermal autoregulatory factor 1 homolog
Polyclonal Antibody for Mouse Deformed epidermal autoregulatory factor 1 homolog
Monoclonal Antibody for Mouse Deformed epidermal autoregulatory factor 1 homolog
Monoclonal Antibody for Mouse Deformed epidermal autoregulatory factor 1 homolog
Monoclonal Antibody for Mouse Deformed epidermal autoregulatory factor 1 homolog
Protein for Mouse Deformed epidermal autoregulatory factor 1 homolog
Protein for Mouse Deformed epidermal autoregulatory factor 1 homolog
Protein for Mouse Deformed epidermal autoregulatory factor 1 homolog
R&D Technical Data
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Precision
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Recovery
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Linearity
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);INTERACTION WITH CLIM2; LMO2 AND LMO4;TISSUE SPECIFICITY
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Pituitary .
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Skin .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2);FUNCTION;SUBCELLULAR LOCATION;DEVELOPMENTAL STAGE
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NOD .
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Pancreas .
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[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
strain :
C57BL/6J .
tissue :
Kidney .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;DISRUPTION PHENOTYPE
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;DEVELOPMENTAL STAGE
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH LMO4;SUBUNIT;SUBCELLULAR LOCATION;MUTAGENESIS OF LYS-305
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Am. J. Hum. Genet.94:649-661(2014)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;DISRUPTION PHENOTYPE