DEDD2 ELISA Kit for Human(Homo sapiens) | EIAab.comDEDD2 ELISA Kit for Human(Homo sapiens)

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DEDD2 (Gene name),

DNA-binding death effector domain-containing protein 2 (Protein name ), DEDD2_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

DEDD2(PSEC0004;FLAME3);

Protein name:

DNA-binding death effector domain-containing protein 2;

Alternative:

FADD-like anti-apoptotic molecule 3;DED-containing protein FLAME-3;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Interacts with CASP8, CASP10 and GTF3C3. Homodimerizes and heterodimerizes with DEDD.

Function:

May play a critical role in death receptor-induced apoptosis and may target CASP8 and CASP10 to the nucleus. May regulate degradation of intermediate filaments during apoptosis. May play a role in the general transcription machinery in the nucleus and might be an important regulator of the activity of GTF3C3.

Subcellular Location:

Nucleus nucleolus Nuclear, accumulated in subnuclear structures resembling nucleoli.

Protein Attributes:

Sequence length:

326

Sequence:

50:

100:

150:

200:

250:

300:

326:

EADYEAGRRR | LLLMEEEGGR | RPTEAS

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

KEGG:

hsa:162989

UniGene:

Hs.515432

Pfam:

PF01335

SMR:

Q8WXF8

STRING:

9606.ENSP00000336972

String:

Q8WXF8

Uniprot:

Q8WXF8

FOR

ELISA Kit for Human DNA-binding death effector domain-containing protein 2

CLIA Kit for Human DNA-binding death effector domain-containing protein 2

Polyclonal Antibody for Human DNA-binding death effector domain-containing protein 2

Monoclonal Antibody for Human DNA-binding death effector domain-containing protein 2

Protein for Human DNA-binding death effector domain-containing protein 2

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Identification and characterization of DEDD2, a death effector domain-containing protein."
Roth W. , Stenner-Liewen F. , Pawlowski K. , Godzik A. , Reed J.C.
J. Biol. Chem.277:7501-7508(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);TISSUE SPECIFICITY;INTERACTION WITH CASP8
2.

"Death effector domain-containing proteins DEDD and FLAME-3 form nuclear complexes with the TFIIIC102 subunit of human transcription factor IIIC."
Zhan Y. , Hegde R. , Srinivasula S.M. , Fernandes-Alnemri T. , Alnemri E.S.
Cell Death Differ.9:439-447(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);TISSUE SPECIFICITY;SUBCELLULAR LOCATION;INTERACTION WITH CASP8 AND GTF3C3
3.

"DEDD regulates degradation of intermediate filaments during apoptosis."
Lee J.C. , Schickling O. , Stegh A.H. , Oshima R.G. , Dinsdale D. , Cohen G.M. , Peter M.E.
J. Cell Biol.158:1051-1066(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
4.

"Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries."
Otsuki T. , Ota T. , Nishikawa T. , Hayashi K. , Suzuki Y. , Yamamoto J. , Wakamatsu A. , Kimura K. , Sakamoto K. , Hatano N. , Kawai Y. , Ishii S. , Saito K. , Kojima S. , Sugiyama T. , Ono T. , Okano K. , Yoshikawa Y. , more...
DNA Res.12:117-126(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue: Teratocarcinoma.
5.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
tissue: Brain.
tissue: Lung.
6.

"DEDD and DEDD2 associate with caspase-8/10 and signal cell death."
Alcivar A. , Hu S. , Tang J. , Yang X.
Oncogene22:291-297(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CASP8 AND CASP10

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