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Index > Protein center > Def6(Gene name) > Mouse
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  • Def6 (Gene name),
  • Differentially expressed in FDCP 6 (Protein name ),  DEFI6_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    Def6(Ibp;Slat);
    Protein name:
    Differentially expressed in FDCP 6(DEF-6);
    Alternative:
    SWAP-70-like adapter of T-cells;IRF4-binding protein;
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Interacts with IRF4, activated RAC1 and F-actin. Both the phosphorylated and non-phosphorylated forms bind phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) (By similarity). Interacts with ZAP70.
    Function:
    Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which plays a role in the activation of Rho GTPases RAC1, RhoA and CDC42. Can regulate cell morphology in cooperation with activated RAC1. Plays a role in Th2 (T helper cells) development and/or activation, perhaps by interfering with ZAP70 signaling. Required for optimal T-cell effector function, lymphocyte homeostasis and the prevention of sytemic autoimmunity.
    Subcellular Location:
    Cytoplasm Cell membrane Nucleus Recruited to the plasma membrane upon binding phosphatidylinositol 3,4,5-trisphosphate.
    Protein Attributes:
    Sequence length:
    630
    Sequence:
    50:
    MALRKELLKS | IWYAFTALDV | EKSGKVSKSQ | LKVLSHNLYT | VLNIPHDPVA | 
    100:
    LEEHFRDDDD | GPVSSQGYMP | YLNKYILDKV | EEGAFVKEHF | DELCWTLTAK | 
    150:
    KNYRADGIGS | SPLSNQDAFR | LWCLFNFLSE | DKYPLIMVPD | EVEYLLKKLL | 
    200:
    GSLSLEMGLG | ELEELLAQDA | QSAQTAVGLS | VWQFLELFNS | GRCLRGVGRD | 
    250:
    SLSMAIQEVY | QELIQDVLKQ | GYLWKRGHLR | RNWAERWFQL | QPSSLCYFGS | 
    300:
    EECKEKRGTI | PLDAHCCVEV | LPDREGKRCM | FCVKTASRTY | EMSASDTRQR | 
    350:
    QEWTAAIQTA | IRLQAEGKTS | LHKDLKQKRR | EQREQRERRR | AAKEEELLRL | 
    400:
    QQLQEEKERK | LQELELLQEA | QRQAERLLQE | EEERRRSQHK | ELQQALEGQL | 
    450:
    REAEQARASM | QAEMELKKEE | AARQRQRIAE | LEEMQERLQE | ALQLEVKARR | 
    500:
    DEEAVRLAQT | RLLEEEEEKL | KQLMHLKEEQ | ERYIERAQQE | KQELQQEMAL | 
    550:
    QSRSLQHAQQ | QLEEVRQNRQ | RADEDVEAAQ | RKLRQASTNV | KHWNVQMNRL | 
    600:
    MHPIEPGDKR | PTTSSSFTGF | QPPPLARRDS | SLKRLTRWGS | QGNRTLSVNS | 
    630:
    SEQKSLNGGD | ETPILALASQ | EEKLDPAPGN | 
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    SMR:
    Pfam:
    String:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse DEF-6
    ELISA Kit for Mouse DEF-6
    CLIA Kit for Mouse DEF-6
    CLIA Kit for Mouse DEF-6
    Polyclonal Antibody for Mouse DEF-6
    Polyclonal Antibody for Mouse DEF-6
    Monoclonal Antibody for Mouse DEF-6
    Monoclonal Antibody for Mouse DEF-6
    Protein for Mouse DEF-6
    Protein for Mouse DEF-6

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "SWAP-70-like adapter of T cells, an adapter protein that regulates early TCR-initiated signaling in Th2 lineage cells."
      Tanaka Y. , Bi K. , Kitamura R. , Hong S. , Altman Y. , Matsumoto A. , Tabata H. , Lebedeva S. , Bushway P.J. , Altman A.
      Immunity18:403-414(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2);FUNCTION;SUBCELLULAR LOCATION;INDUCTION;INTERACTION WITH ZAP70;TISSUE SPECIFICITY
      strain: B10.A.
    2. 2.
      "Molecular cloning of IBP, a SWAP-70 homologous GEF, which is highly expressed in the immune system."
      Gupta S. , Lee A.E. , Hu C. , Fanzo J.C. , Goldberg I. , Cattoretti G. , Pernis A.B.
      Hum. Immunol.64:389-401(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
      strain: C57BL/6.
      tissue: Thymus.
    3. 3.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      strain: C57BL/6J.
      strain: NOD.
      tissue: Thymus.
    4. 4.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
      strain: C57BL/6J.
    5. 5.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Brain.
    6. 6.
      "T cell receptor engagement leads to the recruitment of IBP, a novel guanine nucleotide exchange factor, to the immunological synapse."
      Gupta S. , Fanzo J.C. , Hu C. , Cox D. , Jang S.Y. , Lee A.E. , Greenberg S. , Pernis A.B.
      J. Biol. Chem.278:43541-43549(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DISEASE
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