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Index > Protein center > Dgat1(Gene name) > Mouse
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  • Dgat1 (Gene name),
  • Diacylglycerol O-acyltransferase 1 (Protein name ),  DGAT1_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    Dgat1(Dgat);
    Protein name:
    Diacylglycerol O-acyltransferase 1;
    Alternative:
    Diglyceride acyltransferase;2.3.1.76;Diglyceride acyltransferase(ARAT);
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Homodimer or homotetramer.
    Function:
    Catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates. In contrast to DGAT2 it is not essential for survival. May be involved in VLDL (very low density lipoprotein) assembly.
    Subcellular Location:
    Endoplasmic reticulum membrane Multi-pass membrane protein
    Protein Attributes:
    Sequence length:
    498
    Sequence:
    50:
    MGDRGGAGSS | RRRRTGSRVS | VQGGSGPKVE | EDEVRDAAVS | PDLGAGGDAP | 
    100:
    APAPAPAHTR | DKDGRTSVGD | GYWDLRCHRL | QDSLFSSDSG | FSNYRGILNW | 
    150:
    CVVMLILSNA | RLFLENLIKY | GILVDPIQVV | SLFLKDPYSW | PAPCVIIASN | 
    200:
    IFVVAAFQIE | KRLAVGALTE | QMGLLLHVVN | LATIICFPAA | VALLVESITP | 
    250:
    VGSVFALASY | SIMFLKLYSY | RDVNLWCRQR | RVKAKAVSTG | KKVSGAAAQQ | 
    300:
    AVSYPDNLTY | RDLYYFIFAP | TLCYELNFPR | SPRIRKRFLL | RRVLEMLFFT | 
    350:
    QLQVGLIQQW | MVPTIQNSMK | PFKDMDYSRI | IERLLKLAVP | NHLIWLIFFY | 
    400:
    WFFHSCLNAV | AELLQFGDRE | FYRDWWNAES | VTYFWQNWNI | PVHKWCIRHF | 
    450:
    YKPMLRHGSS | KWVARTGVFL | TSAFFHEYLV | SVPLRMFRLW | AFTAMMAQVP | 
    498:
    LAWIVGRFFQ | GNYGNAAVWV | TLIIGQPVAV | LMYVHDYYVL | NYDAPVGV
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    Pfam:
    String:
    KEGG:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse Diacylglycerol O-acyltransferase 1
    ELISA Kit for Mouse Diacylglycerol O-acyltransferase 1
    ELISA Kit for Mouse Diacylglycerol O-acyltransferase 1
    ELISA Kit for Mouse Diacylglycerol O-acyltransferase 1
    CLIA Kit for Mouse Diacylglycerol O-acyltransferase 1
    CLIA Kit for Mouse Diacylglycerol O-acyltransferase 1
    CLIA Kit for Mouse Diacylglycerol O-acyltransferase 1
    CLIA Kit for Mouse Diacylglycerol O-acyltransferase 1
    Polyclonal Antibody for Mouse Diacylglycerol O-acyltransferase 1
    Polyclonal Antibody for Mouse Diacylglycerol O-acyltransferase 1
    Polyclonal Antibody for Mouse Diacylglycerol O-acyltransferase 1
    Polyclonal Antibody for Mouse Diacylglycerol O-acyltransferase 1
    Monoclonal Antibody for Mouse Diacylglycerol O-acyltransferase 1
    Monoclonal Antibody for Mouse Diacylglycerol O-acyltransferase 1
    Monoclonal Antibody for Mouse Diacylglycerol O-acyltransferase 1
    Monoclonal Antibody for Mouse Diacylglycerol O-acyltransferase 1
    Protein for Mouse Diacylglycerol O-acyltransferase 1
    Protein for Mouse Diacylglycerol O-acyltransferase 1
    Protein for Mouse Diacylglycerol O-acyltransferase 1
    Protein for Mouse Diacylglycerol O-acyltransferase 1

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Identification of a gene encoding an acyl CoA:diacylglycerol acyltransferase, a key enzyme in triacylglycerol synthesis."
      Cases S. , Smith S.J. , Zheng Y.-W. , Myers H.M. , Lear S.R. , Sande E. , Novak S. , Collins C. , Welch C.B. , Lusis A.J. , Erickson S.K. , Farese R.V. Jr.
      Proc. Natl. Acad. Sci. U.S.A.95:13018-13023(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      strain: C57BL/6.
    2. 2.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: C57BL/6J.
      tissue: Tongue.
    3. 3.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
    4. 4.
      "DGAT1 is not essential for intestinal triacylglycerol absorption or chylomicron synthesis."
      Buhman K.K. , Smith S.J. , Stone S.J. , Repa J.J. , Wong J.S. , Knapp F.F.R. Jr. , Burri B.J. , Hamilton R.L. , Abumrad N.A. , Farese R.V. Jr.
      J. Biol. Chem.277:25474-25479(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION PHENOTYPE
    5. 5.
      "Retinol esterification by DGAT1 is essential for retinoid homeostasis in murine skin."
      Shih M.Y. , Kane M.A. , Zhou P. , Yen C.L. , Streeper R.S. , Napoli J.L. , Farese R.V. Jr.
      J. Biol. Chem.284:4292-4299(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CATALYTIC ACTIVITY;FUNCTION
    6. 6.
      "Acyl CoA:Diacylglycerol acyltransferase-1 (DGAT1): topological orientation, identification of a putative active site histidine and the role of the N-terminus in dimer/tetramer formation."
      McFie P.J. , Stone S.L. , Banman S.L. , Stone S.J.
      J. Biol. Chem.285:37377-37387(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS OF HIS-426;SUBUNIT;CATALYTIC ACTIVITY;SUBCELLULAR LOCATION;MEMBRANE TOPOLOGY;FUNCTION
    7. 7.
      "The use of stable isotope-labeled glycerol and oleic acid to differentiate the hepatic functions of DGAT1 and -2."
      Qi J. , Lang W. , Geisler J.G. , Wang P. , Petrounia I. , Mai S. , Smith C. , Askari H. , Struble G.T. , Williams R. , Bhanot S. , Monia B.P. , Bayoumy S. , Grant E. , Caldwell G.W. , Todd M.J. , Liang Y. , Gaul M.D. , more...
      J. Lipid Res.53:1106-1116(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
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