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Index > Protein center > DGAT2(Gene name) > Human
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  • DGAT2 (Gene name),
  • Diacylglycerol O-acyltransferase 2 (Protein name ),  DGAT2_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    DGAT2(HMFN1045;UNQ738/PRO1433);
    Protein name:
    Diacylglycerol O-acyltransferase 2;
    Alternative:
    Diglyceride acyltransferase 2;2.3.1.76;Diglyceride acyltransferase 2(ARAT);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Essential acyltransferase that catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates. Required for synthesis and storage of intracellular triglycerides. Probably plays a central role in cytosolic lipid accumulation.
    Subcellular Location:
    Endoplasmic reticulum membrane Multi-pass membrane protein
    Protein Attributes:
    Sequence length:
    388
    Sequence:
    50:
    MKTLIAAYSG | VLRGERQAEA | DRSQRSHGGP | ALSREGSGRW | GTGSSILSAL | 
    100:
    QDLFSVTWLN | RSKVEKQLQV | ISVLQWVLSF | LVLGVACSAI | LMYIFCTDCW | 
    150:
    LIAVLYFTWL | VFDWNTPKKG | GRRSQWVRNW | AVWRYFRDYF | PIQLVKTHNL | 
    200:
    LTTRNYIFGY | HPHGIMGLGA | FCNFSTEATE | VSKKFPGIRP | YLATLAGNFR | 
    250:
    MPVLREYLMS | GGICPVSRDT | IDYLLSKNGS | GNAIIIVVGG | AAESLSSMPG | 
    300:
    KNAVTLRNRK | GFVKLALRHG | ADLVPIYSFG | ENEVYKQVIF | EEGSWGRWVQ | 
    350:
    KKFQKYIGFA | PCIFHGRGLF | SSDTWGLVPY | SKPITTVVGE | PITIPKLEHP | 
    388:
    TQQDIDLYHT | MYMEALVKLF | DKHKTKFGLP | ETEVLEVN
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    MIM:
    String:
    KEGG:
    UniGene:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Human Diacylglycerol O-acyltransferase 2
    ELISA Kit for Human Diacylglycerol O-acyltransferase 2
    ELISA Kit for Human Diacylglycerol O-acyltransferase 2
    ELISA Kit for Human Diacylglycerol O-acyltransferase 2
    CLIA Kit for Human Diacylglycerol O-acyltransferase 2
    CLIA Kit for Human Diacylglycerol O-acyltransferase 2
    CLIA Kit for Human Diacylglycerol O-acyltransferase 2
    CLIA Kit for Human Diacylglycerol O-acyltransferase 2
    Polyclonal Antibody for Human Diacylglycerol O-acyltransferase 2
    Polyclonal Antibody for Human Diacylglycerol O-acyltransferase 2
    Polyclonal Antibody for Human Diacylglycerol O-acyltransferase 2
    Polyclonal Antibody for Human Diacylglycerol O-acyltransferase 2
    Monoclonal Antibody for Human Diacylglycerol O-acyltransferase 2
    Monoclonal Antibody for Human Diacylglycerol O-acyltransferase 2
    Monoclonal Antibody for Human Diacylglycerol O-acyltransferase 2
    Monoclonal Antibody for Human Diacylglycerol O-acyltransferase 2
    Protein for Human Diacylglycerol O-acyltransferase 2
    Protein for Human Diacylglycerol O-acyltransferase 2
    Protein for Human Diacylglycerol O-acyltransferase 2
    Protein for Human Diacylglycerol O-acyltransferase 2

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Cloning of DGAT2, a second mammalian diacylglycerol acyltransferase, and related family members."
      Cases S. , Stone S.J. , Zhou P. , Yen C.-L.E. , Tow B. , Lardizabal K.D. , Voelker T. , Farese R.V. Jr.
      J. Biol. Chem.276:38870-38876(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];TISSUE SPECIFICITY
      tissue: Testis.
    2. 2.
      "A novel diacylglycerol acyltransferase (DGAT2) is decreased in human psoriatic skin and increased in diabetic mice."
      Wakimoto K. , Chiba H. , Michibata H. , Seishima M. , Kawasaki S. , Okubo K. , Mitsui H. , Torii H. , Imai Y.
      Biochem. Biophys. Res. Commun.310:296-302(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];SUBCELLULAR LOCATION;TISSUE SPECIFICITY
    3. 3.
      "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
      Clark H.F. , Gurney A.L. , Abaya E. , Baker K. , Baldwin D.T. , Brush J. , Chen J. , Chow B. , Chui C. , Crowley C. , Currell B. , Deuel B. , Dowd P. , Eaton D. , Foster J.S. , Grimaldi C. , Gu Q. , Hass P.E. , more...
      Genome Res.13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
    4. 4.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Lymph node.
      tissue: Uterus.
    5. 5.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    6. 6.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Pancreas.
    7. 7.
      "Evaluation of gene structure of human DGAT2 gene."
      Reichwald K. , Petz U. , Platzer M.
      Submitted (2004-10) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 4-341 (ISOFORM 2)
      tissue: Adipocyte.
    8. 8.
      "Expression profiling and differential screening between hepatoblastomas and the corresponding normal livers: identification of high expression of the PLK1 oncogene as a poor-prognostic indicator of hepatoblastomas."
      Yamada S. , Ohira M. , Horie H. , Ando K. , Takayasu H. , Suzuki Y. , Sugano S. , Hirata T. , Goto T. , Matsunaga T. , Hiyama E. , Hayashi Y. , Ando H. , Suita S. , Kaneko M. , Sasaki F. , Hashizume K. , Ohnuma N. , more...
      Oncogene23:5901-5911(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 66-388
      tissue: Hepatoblastoma.
    9. 9.
      "Acyl coenzyme A dependent retinol esterification by acyl coenzyme A: diacylglycerol acyltransferase 1."
      Orland M.D. , Anwar K. , Cromley D. , Chu C.H. , Chen L. , Billheimer J.T. , Hussain M.M. , Cheng D.
      Biochim. Biophys. Acta1737:76-82(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CATALYTIC ACTIVITY
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