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Index > Protein center > Dgat2(Gene name) > Mouse
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  • Dgat2 (Gene name),
  • Diacylglycerol O-acyltransferase 2 (Protein name ),  DGAT2_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    Dgat2;
    Protein name:
    Diacylglycerol O-acyltransferase 2;
    Alternative:
    Diglyceride acyltransferase 2;2.3.1.76;Diglyceride acyltransferase 2(ARAT);
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Essential acyltransferase that catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates. Required for synthesis and storage of intracellular triglycerides. Probably plays a central role in cytosolic lipid accumulation.
    Subcellular Location:
    Endoplasmic reticulum membrane Multi-pass membrane protein
    Protein Attributes:
    Sequence length:
    388
    Sequence:
    50:
    MKTLIAAYSG | VLRGERRAEA | ARSENKNKGS | ALSREGSGRW | GTGSSILSAL | 
    100:
    QDIFSVTWLN | RSKVEKQLQV | ISVLQWVLSF | LVLGVACSVI | LMYTFCTDCW | 
    150:
    LIAVLYFTWL | AFDWNTPKKG | GRRSQWVRNW | AVWRYFRDYF | PIQLVKTHNL | 
    200:
    LTTRNYIFGY | HPHGIMGLGA | FCNFSTEATE | VSKKFPGIRP | YLATLAGNFR | 
    250:
    MPVLREYLMS | GGICPVNRDT | IDYLLSKNGS | GNAIIIVVGG | AAESLSSMPG | 
    300:
    KNAVTLKNRK | GFVKLALRHG | ADLVPTYSFG | ENEVYKQVIF | EEGSWGRWVQ | 
    350:
    KKFQKYIGFA | PCIFHGRGLF | SSDTWGLVPY | SKPITTVVGE | PITVPKLEHP | 
    388:
    TQKDIDLYHA | MYMEALVKLF | DNHKTKFGLP | ETEVLEVN
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    Pfam:
    UniGene:
    KEGG:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse Diacylglycerol O-acyltransferase 2
    ELISA Kit for Mouse Diacylglycerol O-acyltransferase 2
    ELISA Kit for Mouse Diacylglycerol O-acyltransferase 2
    ELISA Kit for Mouse Diacylglycerol O-acyltransferase 2
    CLIA Kit for Mouse Diacylglycerol O-acyltransferase 2
    CLIA Kit for Mouse Diacylglycerol O-acyltransferase 2
    CLIA Kit for Mouse Diacylglycerol O-acyltransferase 2
    CLIA Kit for Mouse Diacylglycerol O-acyltransferase 2
    Polyclonal Antibody for Mouse Diacylglycerol O-acyltransferase 2
    Polyclonal Antibody for Mouse Diacylglycerol O-acyltransferase 2
    Polyclonal Antibody for Mouse Diacylglycerol O-acyltransferase 2
    Polyclonal Antibody for Mouse Diacylglycerol O-acyltransferase 2
    Monoclonal Antibody for Mouse Diacylglycerol O-acyltransferase 2
    Monoclonal Antibody for Mouse Diacylglycerol O-acyltransferase 2
    Monoclonal Antibody for Mouse Diacylglycerol O-acyltransferase 2
    Monoclonal Antibody for Mouse Diacylglycerol O-acyltransferase 2
    Protein for Mouse Diacylglycerol O-acyltransferase 2
    Protein for Mouse Diacylglycerol O-acyltransferase 2
    Protein for Mouse Diacylglycerol O-acyltransferase 2
    Protein for Mouse Diacylglycerol O-acyltransferase 2

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Cloning of DGAT2, a second mammalian diacylglycerol acyltransferase, and related family members."
      Cases S. , Stone S.J. , Zhou P. , Yen C.-L.E. , Tow B. , Lardizabal K.D. , Voelker T. , Farese R.V. Jr.
      J. Biol. Chem.276:38870-38876(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];FUNCTION;TISSUE SPECIFICITY
      tissue: Liver.
    2. 2.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: C57BL/6J.
      tissue: Kidney.
    3. 3.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: FVB/N.
      tissue: Liver.
    4. 4.
      "Concerted elevation of acyl-coenzyme A:diacylglycerol acyltransferase (DGAT) activity through independent stimulation of mRNA expression of DGAT1 and DGAT2 by carbohydrate and insulin."
      Meegalla R.L. , Billheimer J.T. , Cheng D.
      Biochem. Biophys. Res. Commun.298:317-323(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INDUCTION
    5. 5.
      "A novel diacylglycerol acyltransferase (DGAT2) is decreased in human psoriatic skin and increased in diabetic mice."
      Wakimoto K. , Chiba H. , Michibata H. , Seishima M. , Kawasaki S. , Okubo K. , Mitsui H. , Torii H. , Imai Y.
      Biochem. Biophys. Res. Commun.310:296-302(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INDUCTION
    6. 6.
      "Lipopenia and skin barrier abnormalities in DGAT2-deficient mice."
      Stone S.J. , Myers H.M. , Watkins S.M. , Brown B.E. , Feingold K.R. , Elias P.M. , Farese R.V. Jr.
      J. Biol. Chem.279:11767-11776(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION PHENOTYPE
    7. 7.
      "Niacin noncompetitively inhibits DGAT2 but not DGAT1 activity in HepG2 cells."
      Ganji S.H. , Tavintharan S. , Zhu D. , Xing Y. , Kamanna V.S. , Kashyap M.L.
      J. Lipid Res.45:1835-1845(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ENZYME REGULATION
    8. 8.
      "Antisense oligonucleotide reduction of DGAT2 expression improves hepatic steatosis and hyperlipidemia in obese mice."
      Yu X.X. , Murray S.F. , Pandey S.K. , Booten S.L. , Bao D. , Song X.Z. , Kelly S. , Chen S. , McKay R. , Monia B.P. , Bhanot S.
      Hepatology42:362-371(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INDUCTION
    9. 9.
      "Increased very low density lipoprotein secretion and gonadal fat mass in mice overexpressing liver DGAT1."
      Yamazaki T. , Sasaki E. , Kakinuma C. , Yano T. , Miura S. , Ezaki O.
      J. Biol. Chem.280:21506-21514(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    10. 10.
      "Membrane topology and identification of key functional amino acid residues of murine acyl-CoA:diacylglycerol acyltransferase-2."
      Stone S.J. , Levin M.C. , Farese R.V. Jr.
      J. Biol. Chem.281:40273-40282(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;MEMBRANE TOPOLOGY
    11. 11.
      "Murine diacylglycerol acyltransferase-2 (DGAT2) can catalyze triacylglycerol synthesis and promote lipid droplet formation independent of its localization to the endoplasmic reticulum."
      McFie P.J. , Banman S.L. , Kary S. , Stone S.J.
      J. Biol. Chem.286:28235-28246(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBUNIT;FUNCTION;SUBCELLULAR LOCATION
    12. 12.
      "The use of stable isotope-labeled glycerol and oleic acid to differentiate the hepatic functions of DGAT1 and -2."
      Qi J. , Lang W. , Geisler J.G. , Wang P. , Petrounia I. , Mai S. , Smith C. , Askari H. , Struble G.T. , Williams R. , Bhanot S. , Monia B.P. , Bayoumy S. , Grant E. , Caldwell G.W. , Todd M.J. , Liang Y. , Gaul M.D. , more...
      J. Lipid Res.53:1106-1116(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
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