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Index > Protein center > DGKH(Gene name) > Human
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  • DGKH (Gene name),
  • Diacylglycerol kinase eta (Protein name ),  DGKH_HUMAN from NCBI database.
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  • General Annotation
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    • Gene name:
    DGKH;
    Protein name:
    Diacylglycerol kinase eta(DAG kinase eta);
    Alternative:
    Diglyceride kinase eta(DGK-eta);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Isoform 1 forms homooligomers through the SAM domain. Isoform 1 is also able to form heterooligomers with SAM domain-containing isoforms of DGKD. Oligomerization of isoform 1 inhibits its catalytic activity.
    Function:
    Phosphorylates diacylglycerol (DAG) to generate phosphatidic acid (PA).
    Subcellular Location:
    Cytoplasm Translocated from the cytoplasm to endosomes in response to stress stimuli. Isoform 2 is rapidly relocated back to the cytoplasm upon removal of stress stimuli, whereas isoform 1 exhibits sustained endosomal association.
    Protein Attributes:
    Sequence length:
    1220
    Sequence:
    50:
    MAGAGGQHHP | PGAAGGAAAG | AGAAVTSAAA | SAGPGEDSSD | SEAEQEGPQK | 
    100:
    LIRKVSTSGQ | IRTKTSIKEG | QLLKQTSSFQ | RWKKRYFKLR | GRTLYYAKDS | 
    150:
    KSLIFDEVDL | SDASVAEAST | KNANNSFTII | TPFRRLMLCA | ENRKEMEDWI | 
    200:
    SSLKSVQTRE | PYEVAQFNVE | HFSGMHNWYA | CSHARPTFCN | VCRESLSGVT | 
    250:
    SHGLSCEVCK | FKAHKRCAVR | ATNNCKWTTL | ASIGKDIIED | EDGVAMPHQW | 
    300:
    LEGNLPVSAK | CAVCDKTCGS | VLRLQDWKCL | WCKTMVHTAC | KDLYHPICPL | 
    350:
    GQCKVSIIPP | IALNSTDSDG | FCRATFSFCV | SPLLVFVNSK | SGDNQGVKFL | 
    400:
    RRFKQLLNPA | QVFDLMNGGP | HLGLRLFQKF | DNFRILVCGG | DGSVGWVLSE | 
    450:
    IDKLNLNKQC | QLGVLPLGTG | NDLARVLGWG | GSYDDDTQLP | QILEKLERAS | 
    500:
    TKMLDRWSIM | TYELKLPPKA | SLLPGPPEAS | EEFYMTIYED | SVATHLTKIL | 
    550:
    NSDEHAVVIS | SAKTLCETVK | DFVAKVEKTY | DKTLENAVVA | DAVASKCSVL | 
    600:
    NEKLEQLLQA | LHTDSQAAPV | LPGLSPLIVE | EDAVESSSEE | SLGESKEQLG | 
    650:
    DDVTKPSSQK | AVKPREIMLR | ANSLKKAVRQ | VIEEAGKVMD | DPTVHPCEPA | 
    700:
    NQSSDYDSTE | TDESKEEAKD | DGAKESITVK | TAPRSPDARA | SYGHSQTDSV | 
    750:
    PGPAVAASKE | NLPVLNTRII | CPGLRAGLAA | SIAGSSIINK | MLLANIDPFG | 
    800:
    ATPFIDPDLD | SVDGYSEKCV | MNNYFGIGLD | AKISLEFNNK | REEHPEKCRS | 
    850:
    RTKNLMWYGV | LGTRELLQRS | YKNLEQRVQL | ECDGQYIPLP | SLQGIAVLNI | 
    900:
    PSYAGGTNFW | GGTKEDDIFA | APSFDDKILE | VVAIFDSMQM | AVSRVIKLQH | 
    950:
    HRIAQCRTVK | ITIFGDEGVP | VQVDGEAWVQ | PPGIIKIVHK | NRAQMLTRDR | 
    1000:
    AFESTLKSWE | DKQKCDSGKP | VLRTHLYIHH | AIDLATEEVS | QMQLCSQAAE | 
    1050:
    ELITRICDAA | TIHCLLEQEL | AHAVNACSHA | LNKANPRCPE | SLTRDTATEI | 
    1100:
    AINVKALYNE | TESLLVGRVP | LQLESPHEER | VSNALHSVEV | ELQKLTEIPW | 
    1150:
    LYYILHPNED | EEPPMDCTKR | NNRSTVFRIV | PKFKKEKVQK | QKTSSQPVQK | 
    1200:
    WGTEEVAAWL | DLLNLGEYKD | IFIRHDIRGA | ELLHLERRDL | KDLGIPKVGH | 
    1220:
    VKRILQGIKE | LGRSTPQSEV | 
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    Hs.733239
    String:
    Q86XP1
    STRING:
    9606.ENSP00000337572
    UniGene:
    Hs.659437
    KEGG:
    hsa:160851
    SMR:
    Q86XP1
    MIM:
    604071
    Pfam:
    PF00130
    Uniprot:
    Q86XP1
     
    FOR
    ELISA Kit for Human DAG kinase eta
    CLIA Kit for Human DAG kinase eta
    Polyclonal Antibody for Human DAG kinase eta
    Monoclonal Antibody for Human DAG kinase eta
    Protein for Human DAG kinase eta

    R&D Technical Data
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    Precision
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    Recovery
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Linearity
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    References
    1. 1.
      "Identification and characterization of two splice variants of human diacylglycerol kinase eta."
      Murakami T. , Sakane F. , Imai S. , Houkin K. , Kanoh H.
      J. Biol. Chem.278:34364-34372(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2);FUNCTION;CATALYTIC ACTIVITY;SUBUNIT;SUBCELLULAR LOCATION;TISSUE SPECIFICITY;PHOSPHORYLATION;MUTAGENESIS OF TRP-1151
      tissue: Testis.
    2. 2.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4);NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 640-1220 (ISOFORM 2)
      tissue: Testis.
      tissue: Uterus.
    3. 3.
      "The DNA sequence and analysis of human chromosome 13."
      Dunham A. , Matthews L.H. , Burton J. , Ashurst J.L. , Howe K.L. , Ashcroft K.J. , Beare D.M. , Burford D.C. , Hunt S.E. , Griffiths-Jones S. , Jones M.C. , Keenan S.J. , Oliver K. , Scott C.E. , Ainscough R. , Almeida J.P. , Ambrose K.D. , Andrews D.T. , more...
      Nature428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    4. 4.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3)
      tissue: Testis.
    5. 5.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 617-1220 (ISOFORM 1)
      tissue: Amygdala.
    6. 6.
      "Diacylglycerol kinase eta augments C-Raf activity and B-Raf/C-Raf heterodimerization."
      Yasuda S. , Kai M. , Imai S. , Takeishi K. , Taketomi A. , Toyota M. , Kanoh H. , Sakane F.
      J. Biol. Chem.284:29559-29570(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;INTERACTION WITH RAF1 AND BRAF
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