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Index > Protein center > DAGLA(Gene name) > Human
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  • DAGLA (Gene name),
  • Sn1-specific diacylglycerol lipase alpha (Protein name ),  DGLA_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    DAGLA(C11orf11;KIAA0659;NSDDR);
    Protein name:
    Sn1-specific diacylglycerol lipase alpha(DGL-alpha);
    Alternative:
    Neural stem cell-derived dendrite regulator;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Catalyzes the hydrolysis of diacylglycerol (DAG) to 2-arachidonoyl-glycerol (2-AG), the most abundant endocannabinoid in tissues. Required for axonal growth during development and for retrograde synaptic signaling at mature synapses.
    Subcellular Location:
    Cell membrane Multi-pass membrane protein
    Protein Attributes:
    Sequence length:
    1042
    Sequence:
    50:
    MPGIVVFRRR | WSVGSDDLVL | PAIFLFLLHT | TWFVILSVVL | FGLVYNPHEA | 
    100:
    CSLNLVDHGR | GYLGILLSCM | IAEMAIIWLS | MRGGILYTEP | RDSMQYVLYV | 
    150:
    RLAILVIEFI | YAIVGIVWLT | QYYTSCNDLT | AKNVTLGMVV | CNWVVILSVC | 
    200:
    ITVLCVFDPT | GRTFVKLRAT | KRRQRNLRTY | NLRHRLEEGQ | ATSWSRRLKV | 
    250:
    FLCCTRTKDS | QSDAYSEIAY | LFAEFFRDLD | IVPSDIIAGL | VLLRQRQRAK | 
    300:
    RNAVLDEANN | DILAFLSGMP | VTRNTKYLDL | KNSQEMLRYK | EVCYYMLFAL | 
    350:
    AAYGWPMYLM | RKPACGLCQL | ARSCSCCLCP | ARPRFAPGVT | IEEDNCCGCN | 
    400:
    AIAIRRHFLD | ENMTAVDIVY | TSCHDAVYET | PFYVAVDHDK | KKVVISIRGT | 
    450:
    LSPKDALTDL | TGDAERLPVE | GHHGTWLGHK | GMVLSAEYIK | KKLEQEMVLS | 
    500:
    QAFGRDLGRG | TKHYGLIVVG | HSLGAGTAAI | LSFLLRPQYP | TLKCFAYSPP | 
    550:
    GGLLSEDAME | YSKEFVTAVV | LGKDLVPRIG | LSQLEGFRRQ | LLDVLQRSTK | 
    600:
    PKWRIIVGAT | KCIPKSELPE | EVEVTTLAST | RLWTHPSDLT | IALSASTPLY | 
    650:
    PPGRIIHVVH | NHPAEQCCCC | EQEEPTYFAI | WGDNKAFNEV | IISPAMLHEH | 
    700:
    LPYVVMEGLN | KVLENYNKGK | TALLSAAKVM | VSPTEVDLTP | ELIFQQQPLP | 
    750:
    TGPPMPTGLA | LELPTADHRN | SSVRSKSQSE | MSLEGFSEGR | LLSPVVAAAA | 
    800:
    RQDPVELLLL | STQERLAAEL | QARRAPLATM | ESLSDTESLY | SFDSRRSSGF | 
    850:
    RSIRGSPSLH | AVLERDEGHL | FYIDPAIPEE | NPSLSSRTEL | LAADSLSKHS | 
    900:
    QDTQPLEAAL | GSGGVTPERP | PSAAANDEEE | EVGGGGGGPA | SRGELALHNG | 
    950:
    RLGDSPSPQV | LEFAEFIDSL | FNLDSKSSSF | QDLYCMVVPE | SPTSDYAEGP | 
    1000:
    KSPSQQEILL | RAQFEPNLVP | KPPRLFAGSA | DPSSGISLSP | SFPLSSSGEL | 
    1042:
    MDLTPTGLSS | QECLAADKIR | TSTPTGHGAS | PAKQDELVIS | AR
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    SMR:
    UniGene:
    String:
    Pfam:
    KEGG:
    MIM:
    Uniprot:
     
    FOR
    ELISA Kit for Human DGL-alpha
    ELISA Kit for Human DGL-alpha
    ELISA Kit for Human DGL-alpha
    CLIA Kit for Human DGL-alpha
    CLIA Kit for Human DGL-alpha
    CLIA Kit for Human DGL-alpha
    Polyclonal Antibody for Human DGL-alpha
    Polyclonal Antibody for Human DGL-alpha
    Polyclonal Antibody for Human DGL-alpha
    Monoclonal Antibody for Human DGL-alpha
    Monoclonal Antibody for Human DGL-alpha
    Monoclonal Antibody for Human DGL-alpha
    Protein for Human DGL-alpha
    Protein for Human DGL-alpha
    Protein for Human DGL-alpha

    R&D Technical Data
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    Precision
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Recovery
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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    References
    1. 1.
      "NSDDR a novel tetra-spanning transmembrane protein with a unique integration pattern to the plasma membrane regulates the extension of the dendritic trees of Purkinje cells."
      Horiguchi S. , Tashiro K. , Takahashi J. , Hashimoto N. , Nakano I. , Tsuchida Y. , Hirai H. , Honjo T.
      Submitted (2003-04) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    2. 2.
      "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
      Ishikawa K. , Nagase T. , Suyama M. , Miyajima N. , Tanaka A. , Kotani H. , Nomura N. , Ohara O.
      DNA Res.5:169-176(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Brain.
    3. 3.
      "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
      Nakajima D. , Okazaki N. , Yamakawa H. , Kikuno R. , Ohara O. , Nagase T.
      DNA Res.9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SEQUENCE REVISION
    4. 4.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 5.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
    6. 6.
      "Cloning of the first sn1-DAG lipases points to the spatial and temporal regulation of endocannabinoid signaling in the brain."
      Bisogno T. , Howell F. , Williams G. , Minassi A. , Cascio M.G. , Ligresti A. , Matias I. , Schiano-Moriello A. , Paul P. , Williams E.-J. , Gangadharan U. , Hobbs C. , Di Marzo V. , Doherty P.
      J. Cell Biol.163:463-468(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;COFACTOR;BIOPHYSICOCHEMICAL PROPERTIES;ENZYME REGULATION;TISSUE SPECIFICITY
    7. 7.
      "Stimulation of endocannabinoid formation in brain slice cultures through activation of group I metabotropic glutamate receptors."
      Jung K.-M. , Mangieri R. , Stapleton C. , Kim J. , Fegley D. , Wallace M. , Mackie K. , Piomelli D.
      Mol. Pharmacol.68:1196-1202(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
    8. 8.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: POSSIBLE INVOLVEMENT IN SCA20
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