Gene name:
Hsd17b12 (Kik1) ;
Protein name:
Estradiol 17-beta-dehydrogenase 12 ;
Alternative:
1.3.1.-;3-ketoacyl-CoA reductase (KAR) ;17-beta-hydroxysteroid dehydrogenase 12 (17-beta-HSD 12) ;KIK-I ;
Organism:
Mouse (Mus musculus).
General Annotation
Function:
Catalyzes the transformation of estrone (E1) into estradiol (E2), suggesting a central role in estrogen formation. Its strong expression in ovary and mammary gland suggest that it may constitute the major enzyme responsible for the conversion of E1 to E2 in females. Also has 3-ketoacyl-CoA reductase activity, reducing both long chain 3-ketoacyl-CoAs and long chain fatty acyl-CoAs, suggesting a role in long fatty acid elongation.
Subcellular Location:
Endoplasmic reticulum membrane
Multi-pass membrane protein
Protein Attributes:
50:
MECAPPAAGF | LYWVGASTIA | YLALRASYSL | FRAFQVWCVG | NEALVGPRLG |
100:
EWAVVTGGTD | GIGKAYAEEL | AKRGMKIVLI | SRSQDKLNQV | SNNIKEKFNV |
150:
ETRTIAVDFS | LDDIYDKIKT | GLSGLEIGVL | VNNVGMSYEY | PEYFLEIPDL |
200:
DNTIKKLINI | NVLSVCKVTR | LVLPGMVERS | KGVILNISSA | SGMLPVPLLT |
250:
IYSATKAFVD | FFSQCLHEEY | KSKGIFVQSV | MPYLVATKLA | KIQKPTLDKP |
300:
SAETFVKSAI | KTVGLQTRTT | GYVIHSLMGS | INSIMPRWMY | FKIIMGFSKS |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Rat
Bovine
Human
Mouse
ELISA Kit for Mouse Estradiol 17-beta-dehydrogenase 12
ELISA Kit for Mouse Estradiol 17-beta-dehydrogenase 12
ELISA Kit for Mouse Estradiol 17-beta-dehydrogenase 12
ELISA Kit for Mouse Estradiol 17-beta-dehydrogenase 12
CLIA Kit for Mouse Estradiol 17-beta-dehydrogenase 12
CLIA Kit for Mouse Estradiol 17-beta-dehydrogenase 12
CLIA Kit for Mouse Estradiol 17-beta-dehydrogenase 12
CLIA Kit for Mouse Estradiol 17-beta-dehydrogenase 12
Polyclonal Antibody for Mouse Estradiol 17-beta-dehydrogenase 12
Polyclonal Antibody for Mouse Estradiol 17-beta-dehydrogenase 12
Polyclonal Antibody for Mouse Estradiol 17-beta-dehydrogenase 12
Polyclonal Antibody for Mouse Estradiol 17-beta-dehydrogenase 12
Monoclonal Antibody for Mouse Estradiol 17-beta-dehydrogenase 12
Monoclonal Antibody for Mouse Estradiol 17-beta-dehydrogenase 12
Monoclonal Antibody for Mouse Estradiol 17-beta-dehydrogenase 12
Monoclonal Antibody for Mouse Estradiol 17-beta-dehydrogenase 12
Protein for Mouse Estradiol 17-beta-dehydrogenase 12
Protein for Mouse Estradiol 17-beta-dehydrogenase 12
Protein for Mouse Estradiol 17-beta-dehydrogenase 12
Protein for Mouse Estradiol 17-beta-dehydrogenase 12
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
strain :
BALB/c .
tissue :
Liver .
2.
"The transcriptional landscape of the mammalian genome."
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
strain :
BALB/c .
strain :
C57BL/6J .
strain :
NOD .
tissue :
Bone marrow .
tissue :
Cerebellum .
tissue :
Colon .
tissue :
Head .
tissue :
Lung .
tissue :
Thymus .
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
strain :
FVB/N-3 .
tissue :
Mammary tumor .
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : TISSUE SPECIFICITY