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Index > Protein center > DIS3L(Gene name) > Human
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  • DIS3L (Gene name),
  • DIS3-like exonuclease 1 (Protein name ),  DI3L1_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    DIS3L(KIAA1955;KIAA1955);
    Protein name:
    DIS3-like exonuclease 1;
    Alternative:

    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Component of the RNA exosome complex. The catalytically inactive RNA exosome core (Exo-9) complex is believed to associate with catalytic subunits EXOSC10, and DIS3 or DIS3L in cytoplasmic-and nuclear-specific RNA exosome complex forms.
    Function:
    Putative cytoplasm-specific catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA.
    Subcellular Location:
    Cytoplasm
    Protein Attributes:
    Sequence length:
    1054
    Sequence:
    50:
    MLQKREKVLL | LRTFQGRTLR | IVREHYLRPC | VPCHSPLCPQ | PAACSHDGKL | 
    100:
    LSSDVTHYVI | PDWKVVQDYL | EILEFPELKG | IIFMQTACQA | VQHQRGRRQY | 
    150:
    NKLRNLLKDA | RHDCILFANE | FQQCCYLPRE | RGESMEKWQT | RSIYNAAVWY | 
    200:
    YHHCQDRMPI | VMVTEDEEAI | QQYGSETEGV | FVITFKNYLD | NFWPDLKAAH | 
    250:
    ELCDSILQSR | RERENESQES | HGKEYPEHLP | LEVLEAGIKS | GRYIQGILNV | 
    300:
    NKHRAQIEAF | VRLQGASSKD | SDLVSDILIH | GMKARNRSIH | GDVVVVELLP | 
    350:
    KNEWKGRTVA | LCENDCDDKA | SGESPSEPMP | TGRVVGILQK | NWRDYVVTFP | 
    400:
    SKEEVQSQGK | NAQKILVTPW | DYRIPKIRIS | TQQAETLQDF | RVVVRIDSWE | 
    450:
    STSVYPNGHF | VRVLGRIGDL | EGEIATILVE | NSISVIPFSE | AQMCEMPVNT | 
    500:
    PESPWKVSPE | EEQKRKDLRK | SHLVFSIDPK | GCEDVDDTLS | VRTLNNGNLE | 
    550:
    LGVHIADVTH | FVAPNSYIDI | EARTRATTYY | LADRRYDMLP | SVLSADLCSL | 
    600:
    LGGVDRYAVS | IMWELDKASY | EIKKVWYGRT | IIRSAYKLFY | EAAQELLDGN | 
    650:
    LSVVDDIPEF | KDLDEKSRQA | KLEELVWAIG | KLTDIARHVR | AKRDGCGALE | 
    700:
    LEGVEVCVQL | DDKKNIHDLI | PKQPLEVHET | VAECMILANH | WVAKKIWESF | 
    750:
    PHQALLRQHP | PPHQEFFSEL | RECAKAKGFF | IDTRSNKTLA | DSLDNANDPH | 
    800:
    DPIVNRLLRS | MATQAMSNAL | YFSTGSCAEE | EFHHYGLALD | KYTHFTSPIR | 
    850:
    RYSDIVVHRL | LMAAISKDKK | MEIKGNLFSN | KDLEELCRHI | NNRNQAAQHS | 
    900:
    QKQSTELFQC | MYFKDKDPAT | EERCISDGVI | YSIRTNGVLL | FIPRFGIKGA | 
    950:
    AYLKNKDGLV | ISCGPDSCSE | WKPGSLQRFQ | NKITSTTTDG | ESVTFHLFDH | 
    1000:
    VTVRISIQAS | RCHSDTIRLE | IISNKPYKIP | NTELIHQSSP | LLKSELVKEV | 
    1050:
    TKSVEEAQLA | QEVKVNIIQE | EYQEYRQTKG | RSLYTLLEEI | RDLALLDVSN | 
    1054:
    NYGI
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    MIM:
    Pfam:
    UniGene:
    SMR:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Human DIS3-like exonuclease 1
    ELISA Kit for Human DIS3-like exonuclease 1
    ELISA Kit for Human DIS3-like exonuclease 1
    ELISA Kit for Human DIS3-like exonuclease 1
    CLIA Kit for Human DIS3-like exonuclease 1
    CLIA Kit for Human DIS3-like exonuclease 1
    CLIA Kit for Human DIS3-like exonuclease 1
    CLIA Kit for Human DIS3-like exonuclease 1
    Polyclonal Antibody for Human DIS3-like exonuclease 1
    Polyclonal Antibody for Human DIS3-like exonuclease 1
    Polyclonal Antibody for Human DIS3-like exonuclease 1
    Polyclonal Antibody for Human DIS3-like exonuclease 1
    Monoclonal Antibody for Human DIS3-like exonuclease 1
    Monoclonal Antibody for Human DIS3-like exonuclease 1
    Monoclonal Antibody for Human DIS3-like exonuclease 1
    Monoclonal Antibody for Human DIS3-like exonuclease 1
    Protein for Human DIS3-like exonuclease 1
    Protein for Human DIS3-like exonuclease 1
    Protein for Human DIS3-like exonuclease 1
    Protein for Human DIS3-like exonuclease 1

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins."
      Nagase T. , Kikuno R. , Ohara O.
      DNA Res.8:319-327(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
      tissue: Brain.
    2. 2.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3);VARIANT GLY-614
      tissue: Tongue.
    3. 4.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    4. 5.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4);VARIANT GLY-614
      tissue: Kidney.
      tissue: Muscle.
    5. 6.
      "The human core exosome interacts with differentially localized processive RNases: hDIS3 and hDIS3L."
      Tomecki R. , Kristiansen M.S. , Lykke-Andersen S. , Chlebowski A. , Larsen K.M. , Szczesny R.J. , Drazkowska K. , Pastula A. , Andersen J.S. , Stepien P.P. , Dziembowski A. , Jensen T.H.
      EMBO J.29:2342-2357(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ASSOCIATION WITH THE RNA EXOSOME COMPLEX;IDENTIFICATION BY MASS SPECTROMETRY;FUNCTION;COFACTOR;SUBCELLULAR LOCATION;MUTAGENESIS OF ASP-486
    6. 7.
      "Dis3-like 1: a novel exoribonuclease associated with the human exosome."
      Staals R.H. , Bronkhorst A.W. , Schilders G. , Slomovic S. , Schuster G. , Heck A.J. , Raijmakers R. , Pruijn G.J.
      EMBO J.29:2358-2367(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;COFACTOR;SUBCELLULAR LOCATION;MUTAGENESIS OF ASP-62; ASP-166 AND ASP-486
    7. 8.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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