Gene name:
DIS3L (KIAA1955;KIAA1955) ;
Protein name:
DIS3-like exonuclease 1 ;
Alternative:
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Component of the RNA exosome complex. The catalytically inactive RNA exosome core (Exo-9) complex is believed to associate with catalytic subunits EXOSC10, and DIS3 or DIS3L in cytoplasmic-and nuclear-specific RNA exosome complex forms.
Function:
Putative cytoplasm-specific catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA.
Subcellular Location:
Cytoplasm
Protein Attributes:
50:
MLQKREKVLL | LRTFQGRTLR | IVREHYLRPC | VPCHSPLCPQ | PAACSHDGKL |
100:
LSSDVTHYVI | PDWKVVQDYL | EILEFPELKG | IIFMQTACQA | VQHQRGRRQY |
150:
NKLRNLLKDA | RHDCILFANE | FQQCCYLPRE | RGESMEKWQT | RSIYNAAVWY |
200:
YHHCQDRMPI | VMVTEDEEAI | QQYGSETEGV | FVITFKNYLD | NFWPDLKAAH |
250:
ELCDSILQSR | RERENESQES | HGKEYPEHLP | LEVLEAGIKS | GRYIQGILNV |
300:
NKHRAQIEAF | VRLQGASSKD | SDLVSDILIH | GMKARNRSIH | GDVVVVELLP |
350:
KNEWKGRTVA | LCENDCDDKA | SGESPSEPMP | TGRVVGILQK | NWRDYVVTFP |
400:
SKEEVQSQGK | NAQKILVTPW | DYRIPKIRIS | TQQAETLQDF | RVVVRIDSWE |
450:
STSVYPNGHF | VRVLGRIGDL | EGEIATILVE | NSISVIPFSE | AQMCEMPVNT |
500:
PESPWKVSPE | EEQKRKDLRK | SHLVFSIDPK | GCEDVDDTLS | VRTLNNGNLE |
550:
LGVHIADVTH | FVAPNSYIDI | EARTRATTYY | LADRRYDMLP | SVLSADLCSL |
600:
LGGVDRYAVS | IMWELDKASY | EIKKVWYGRT | IIRSAYKLFY | EAAQELLDGN |
650:
LSVVDDIPEF | KDLDEKSRQA | KLEELVWAIG | KLTDIARHVR | AKRDGCGALE |
700:
LEGVEVCVQL | DDKKNIHDLI | PKQPLEVHET | VAECMILANH | WVAKKIWESF |
750:
PHQALLRQHP | PPHQEFFSEL | RECAKAKGFF | IDTRSNKTLA | DSLDNANDPH |
800:
DPIVNRLLRS | MATQAMSNAL | YFSTGSCAEE | EFHHYGLALD | KYTHFTSPIR |
850:
RYSDIVVHRL | LMAAISKDKK | MEIKGNLFSN | KDLEELCRHI | NNRNQAAQHS |
900:
QKQSTELFQC | MYFKDKDPAT | EERCISDGVI | YSIRTNGVLL | FIPRFGIKGA |
950:
AYLKNKDGLV | ISCGPDSCSE | WKPGSLQRFQ | NKITSTTTDG | ESVTFHLFDH |
1000:
VTVRISIQAS | RCHSDTIRLE | IISNKPYKIP | NTELIHQSSP | LLKSELVKEV |
1050:
TKSVEEAQLA | QEVKVNIIQE | EYQEYRQTKG | RSLYTLLEEI | RDLALLDVSN |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Bovine
Mouse
Rat
Human
ELISA Kit for Human DIS3-like exonuclease 1
ELISA Kit for Human DIS3-like exonuclease 1
ELISA Kit for Human DIS3-like exonuclease 1
ELISA Kit for Human DIS3-like exonuclease 1
CLIA Kit for Human DIS3-like exonuclease 1
CLIA Kit for Human DIS3-like exonuclease 1
CLIA Kit for Human DIS3-like exonuclease 1
CLIA Kit for Human DIS3-like exonuclease 1
Polyclonal Antibody for Human DIS3-like exonuclease 1
Polyclonal Antibody for Human DIS3-like exonuclease 1
Polyclonal Antibody for Human DIS3-like exonuclease 1
Polyclonal Antibody for Human DIS3-like exonuclease 1
Monoclonal Antibody for Human DIS3-like exonuclease 1
Monoclonal Antibody for Human DIS3-like exonuclease 1
Monoclonal Antibody for Human DIS3-like exonuclease 1
Monoclonal Antibody for Human DIS3-like exonuclease 1
Protein for Human DIS3-like exonuclease 1
Protein for Human DIS3-like exonuclease 1
Protein for Human DIS3-like exonuclease 1
Protein for Human DIS3-like exonuclease 1
R&D Technical Data
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Precision
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Recovery
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Linearity
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
tissue :
Brain .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3);VARIANT GLY-614
tissue :
Tongue .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4);VARIANT GLY-614
tissue :
Kidney .
tissue :
Muscle .
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EMBO J.29:2342-2357(2010)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ASSOCIATION WITH THE RNA EXOSOME COMPLEX;IDENTIFICATION BY MASS SPECTROMETRY;FUNCTION;COFACTOR;SUBCELLULAR LOCATION;MUTAGENESIS OF ASP-486
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]