Gene name:
Dicer1 (Dicer;Mdcr) ;
Protein name:
Endoribonuclease Dicer ;
Alternative:
Double-strand-specific ribonuclease mDCR-1 ;
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Component of the RISC loading complex (RLC), or micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, EIF2C2/AGO2 and TARBP2. Note that the trimeric RLC/miRLC is also referred to as RISC. Interacts with DHX9, EIF2C1, PIWIL1 and PRKRA. Associates with the 60S ribosome.
Function:
Involved in cleaving double-stranded RNA in the RNA interference (RNAi) pathway. It produces 21 to 23 bp dsRNAs (siRNAs) which target the selective destruction of homologous RNAs.
Subcellular Location:
Cytoplasm
Protein Attributes:
50:
MKSPALQPLS | MAGLQLMTPA | SSPMGPFFGL | PWQQEAIHDN | IYTPRKYQVE |
100:
LLEAALDHNT | IVCLNTGSGK | TFIAVLLTKE | LAHQIRGDLN | PHAKRTVFLV |
150:
NSANQVAQQV | SAVRTHSDLK | VGEYSDLEVN | ASWTKERWSQ | EFTKHQVLIM |
200:
TCYVALTVLK | NGYLSLSDIN | LLVFDECHLA | ILDHPYREIM | KLCESCPSCP |
250:
RILGLTASIL | NGKCDPEELE | EKIQKLERIL | RSDAETATDL | VVLDRYTSQP |
300:
CEIVVDCGPF | TDRSGLYERL | LMELEAALDF | INDCNVAVHS | KERDSTLISK |
350:
QILSDCRAVL | VVLGPWCADK | VAGMMVRELQ | KYIKHEQEEL | HRKFLLFTDT |
400:
LLRKIHALCE | EYFSPASLDL | KYVTPKVMKL | LEILRKYKPY | ERQQFESVEW |
450:
YNNRNQDNYV | SWSDSEDDDD | DEEIEEKEKP | ETNFPSPFTN | ILCGIIFVER |
500:
RYTAVVLNRL | IKEAGKQDPE | LAYISSNFIT | GHGIGKNQPR | SKQMEAEFRK |
550:
QEEVLRKFRA | HETNLLIATS | VVEEGVDIPK | CNLVVRFDLP | TEYRSYVQSK |
600:
GRARAPISNY | VMLADTDKIK | SFEEDLKTYK | AIEKILRNKC | SKSADGAEAD |
650:
VHAGVDDEDA | FPPYVLRPDD | GGPRVTINTA | IGHINRYCAR | LPSDPFTHLA |
700:
PKCRTRELPD | GTFYSTLYLP | INSPLRASIV | GPPMDSVRLA | ERVVALICCE |
750:
KLHKIGELDE | HLMPVGKETV | KYEEELDLHD | EEETSVPGRP | GSTKRRQCYP |
800:
KAIPECLRES | YPKPDQPCYL | YVIGMVLTTP | LPDELNFRRR | KLYPPEDTTR |
850:
CFGILTAKPI | PQIPHFPVYT | RSGEVTISIE | LKKSGFTLSQ | QMLELITRLH |
900:
QYIFSHILRL | EKPALEFKPT | GAESAYCVLP | LNVVNDSGTL | DIDFKFMEDI |
950:
EKSEARIGIP | STKYSKETPF | VFKLEDYQDA | VIIPRYRNFD | QPHRFYVADV |
1000:
YTDLTPLSKF | PSPEYETFAE | YYKTKYNLDL | TNLNQPLLDV | DHTSSRLNLL |
1050:
TPRHLNQKGK | ALPLSSAEKR | KAKWESLQNK | QILVPELCAI | HPIPASLWRK |
1100:
AVCLPSILYR | LHCLLTAEEL | RAQTASDAGV | GVRSLPVDFR | YPNLDFGWKK |
1150:
SIDSKSFIST | CNSSLAESDN | YCKHSTTVVP | EHAAHQGATR | PSLENHDQMS |
1200:
VNCKRLPAES | PAKLQSEVST | DLTAINGLSY | NKNLANGSYD | LVNRDFCQGN |
1250:
QLNYFKQEIP | VQPTTSYPIQ | NLYNYENQPK | PSNECPLLSN | TYLDGNANTS |
1300:
TSDGSPAVST | MPAMMNAVKA | LKDRMDSEQS | PSVGYSSRTL | GPNPGLILQA |
1350:
LTLSNASDGF | NLERLEMLGD | SFLKHAITTY | LFCTYPDAHE | GRLSYMRSKK |
1400:
VSNCNLYRLG | KKKGLPSRMV | VSIFDPPVNW | LPPGYVVNQD | KSNSEKWEKD |
1450:
EMTKDCLLAN | GKLGEACEEE | EDLTWRAPKE | EAEDEDDFLE | YDQEHIQFID |
1500:
SMLMGSGAFV | RKISLSPFSA | SDSAYEWKMP | KKASLGSMPF | ASGLEDFDYS |
1550:
SWDAMCYLDP | SKAVEEDDFV | VGFWNPSEEN | CGVDTGKQSI | SYDLHTEQCI |
1600:
ADKSIADCVE | ALLGCYLTSC | GERAAQLFLC | SLGLKVLPVI | KRTSREKALD |
1650:
PAQENGSSQQ | KSLSGSCAAP | VGPRSSAGKD | LEYGCLKIPP | RCMFDHPDAE |
1700:
KTLNHLISGF | ETFEKKINYR | FKNKAYLLQA | FTHASYHYNT | ITDCYQRLEF |
1750:
LGDAILDYLI | TKHLYEDPRQ | HSPGVLTDLR | SALVNNTIFA | SLAVKYDYHK |
1800:
YFKAVSPELF | HVIDDFVKFQ | LEKNEMQGMD | SELRRSEEDE | EKEEDIEVPK |
1850:
AMGDIFESLA | GAIYMDSGMS | LEVVWQVYYP | MMQPLIEKFS | ANVPRSPVRE |
1900:
LLEMEPETAK | FSPAERTYDG | KVRVTVEVVG | KGKFKGVGRS | YRIAKSAAAR |
1916:
RALRSLKANQ | PQVPNS
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
Chicken
Bovine
ELISA Kit for Mouse Endoribonuclease Dicer
ELISA Kit for Mouse Endoribonuclease Dicer
ELISA Kit for Mouse Endoribonuclease Dicer
ELISA Kit for Mouse Endoribonuclease Dicer
CLIA Kit for Mouse Endoribonuclease Dicer
CLIA Kit for Mouse Endoribonuclease Dicer
CLIA Kit for Mouse Endoribonuclease Dicer
CLIA Kit for Mouse Endoribonuclease Dicer
Polyclonal Antibody for Mouse Endoribonuclease Dicer
Polyclonal Antibody for Mouse Endoribonuclease Dicer
Polyclonal Antibody for Mouse Endoribonuclease Dicer
Polyclonal Antibody for Mouse Endoribonuclease Dicer
Monoclonal Antibody for Mouse Endoribonuclease Dicer
Monoclonal Antibody for Mouse Endoribonuclease Dicer
Monoclonal Antibody for Mouse Endoribonuclease Dicer
Monoclonal Antibody for Mouse Endoribonuclease Dicer
Protein for Mouse Endoribonuclease Dicer
Protein for Mouse Endoribonuclease Dicer
Protein for Mouse Endoribonuclease Dicer
Protein for Mouse Endoribonuclease Dicer
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 17-1916
strain :
C57BL/6J .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
strain :
Czech II .
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION OF ISOFORM 2;FUNCTION (ISOFORMS 1 AND 2);DISRUPTION PHENOTYPE (ISOFORM 2);TISSUE SPECIFICITY (ISOFORMS 1 AND 2)
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (1.68 ANGSTROMS) OF 1647-1910;MUTAGENESIS OF LYS-1800