Class II histocompatibility antigen, M alpha chain (Protein name
), DMA_MOUSE from NCBI database.
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General Annotation
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Antigen Annotation
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Gene name:
H2-DMa(H2-Ma;Ma);
Protein name:
Class II histocompatibility antigen, M alpha chain;
Alternative:
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Heterodimer of an alpha chain (DMA) and a beta chain (DMB).
Function:
Plays a critical role in catalyzing the release of class II HLA-associated invariant chain-derived peptides (CLIP) from newly synthesized class II HLA molecules and freeing the peptide binding site for acquisition of antigenic peptides.
Subcellular Location:
Late endosome membrane
Single-pass type I membrane protein
Lysosome membrane
Single-pass type I membrane protein
Localizes to late endocytic compartment. Associates with lysosome membranes.
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Cited for: X-RAY CRYSTALLOGRAPHY (3.1 ANGSTROMS) OF 30-220;SUBUNIT;GLYCOSYLATION AT ASN-41;DISULFIDE BONDS
Vaild Sequence:
