Gene name:
HLA-DMB(DMB;RING7);
Protein name:
HLA class II histocompatibility antigen, DM beta chain;
Alternative:
Really interesting new gene 7 protein;MHC class II antigen DMB;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Heterodimer of an alpha chain (DMA) and a beta chain (DMB).
Function:
Plays a critical role in catalyzing the release of class II-associated invariant chain peptide (CLIP) from newly synthesized MHC class II molecules and freeing the peptide binding site for acquisition of antigenic peptides. In B cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO.
Subcellular Location:
Late endosome membrane
Single-pass type I membrane protein
Lysosome membrane
Single-pass type I membrane protein
Localizes to late endocytic compartment. Associates with lysosome membranes.
Protein Attributes:
50:
MITFLPLLLG | LSLGCTGAGG | FVAHVESTCL | LDDAGTPKDF | TYCISFNKDL |
100:
LTCWDPEENK | MAPCEFGVLN | SLANVLSQHL | NQKDTLMQRL | RNGLQNCATH |
150:
TQPFWGSLTN | RTRPPSVQVA | KTTPFNTREP | VMLACYVWGF | YPAEVTITWR |
200:
KNGKLVMPHS | SAHKTAQPNG | DWTYQTLSHL | ALTPSYGDTY | TCVVEHIGAP |
250:
EPILRDWTPG | LSPMQTLKVS | VSAVTLGLGL | IIFSLGVISW | RRAGHSSYTP |
Vaild Sequence:
Related Databases
Uniprot:
