Dnd1 ELISA Kit for Mouse(Mus musculus) | EIAab.comDnd1 ELISA Kit for Mouse(Mus musculus)

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Index > Protein center > Dnd1(Gene name) > Mouse

Dnd1 (Gene name),

Dead end protein homolog 1 (Protein name ), DND1_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

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Gene name:

Dnd1(Rbms4;Ter);

Protein name:

Dead end protein homolog 1;

Alternative:

RNA-binding motif, single-stranded-interacting protein 4;

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Interacts with APOBEC3.

Function:

RNA-binding factor that positively regulates gene expression by prohibiting miRNA-mediated gene suppression (By similarity). Relieves miRNA repression in germline cells (By similarity). Prohibits the function of several miRNAs by blocking the accessibility of target mRNAs (By similarity). Sequence-specific RNA-binding factor that binds specifically to U-rich regions (URRs) in the 3' untranslated region (3'-UTR) of several mRNAs (By similarity). Does not bind to miRNAs (By similarity). Isoform 1 may play a role during primordial germ cell (PGC) survival. However, does not seem to be essential for PGC migration.

Subcellular Location:

Nucleus Cytoplasm Perinuclear germ granules, also called germ plasm or chromatoid body (By similarity). Colocalizes in perinuclear sites with APOBEC3.

Protein Attributes:

Sequence length:

352

Sequence:

50:

100:

150:

200:

250:

300:

350:

352:

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

Mm.234464

KEGG:

mmu:213236

String:

Q6VY05

STRING:

10090.ENSMUSP00000054412

SMR:

Q6VY05

Pfam:

PF00076

Uniprot:

Q6VY05

FOR

ELISA Kit for Mouse Dead end protein homolog 1

CLIA Kit for Mouse Dead end protein homolog 1

Polyclonal Antibody for Mouse Dead end protein homolog 1

Monoclonal Antibody for Mouse Dead end protein homolog 1

Protein for Mouse Dead end protein homolog 1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Dead end, a novel vertebrate germ plasm component, is required for zebrafish primordial germ cell migration and survival."
Weidinger G. , Stebler J. , Slanchev K. , Dumstrei K. , Wise C. , Lovell-Badge R. , Thisse C. , Thisse B. , Raz E.
Curr. Biol.13:1429-1434(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
strain: C57BL/6J.
tissue: Testis.
2.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
strain: C57BL/6.
tissue: Thymus.
3.

"The Ter mutation in the dead end gene causes germ cell loss and testicular germ cell tumours."
Youngren K.K. , Coveney D. , Peng X. , Bhattacharya C. , Schmidt L.S. , Nickerson M.L. , Lamb B.T. , Deng J.M. , Behringer R.R. , Capel B. , Rubin E.M. , Nadeau J.H. , Matin A.
Nature435:360-364(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY;DEVELOPMENTAL STAGE;DISEASE
4.

"The mouse dead-end gene isoform alpha is necessary for germ cell and embryonic viability."
Bhattacharya C. , Aggarwal S. , Zhu R. , Kumar M. , Zhao M. , Meistrich M.L. , Matin A.
Biochem. Biophys. Res. Commun.355:194-199(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ALTERNATIVE SPLICING (ISOFORMS 1 AND 2);SUBCELLULAR LOCATION;TISSUE SPECIFICITY;DEVELOPMENTAL STAGE
5.

"Mouse apolipoprotein B editing complex 3 (APOBEC3) is expressed in germ cells and interacts with dead-end (DND1)."
Bhattacharya C. , Aggarwal S. , Kumar M. , Ali A. , Matin A.
PLoS ONE3:E2315-E2315(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH APOBEC3;SUBCELLULAR LOCATION;DEVELOPMENTAL STAGE

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