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Index > Protein center > DNASE2(Gene name) > Human
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  • DNASE2 (Gene name),
  • Deoxyribonuclease-2-alpha (Protein name ),  DNS2A_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    DNASE2(DNASE2A;DNL2);
    Protein name:
    Deoxyribonuclease-2-alpha;
    Alternative:
    Deoxyribonuclease II alpha(DNase II alpha);Acid DNase;R31240_2;Lysosomal DNase II;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Hydrolyzes DNA under acidic conditions with a preference for double-stranded DNA. Plays a major role in the degradation of nuclear DNA in cellular apoptosis during development. Necessary for proper fetal development and for definitive erythropoiesis in fetal liver, where it degrades nuclear DNA expelled from erythroid precursor cells.
    Subcellular Location:
    Lysosome
    Protein Attributes:
    Sequence length:
    360
    Sequence:
    50:
    MIPLLLAALL | CVPAGALTCY | GDSGQPVDWF | VVYKLPALRG | SGEAAQRGLQ | 
    100:
    YKYLDESSGG | WRDGRALINS | PEGAVGRSLQ | PLYRSNTSQL | AFLLYNDQPP | 
    150:
    QPSKAQDSSM | RGHTKGVLLL | DHDGGFWLVH | SVPNFPPPAS | SAAYSWPHSA | 
    200:
    CTYGQTLLCV | SFPFAQFSKM | GKQLTYTYPW | VYNYQLEGIF | AQEFPDLENV | 
    250:
    VKGHHVSQEP | WNSSITLTSQ | AGAVFQSFAK | FSKFGDDLYS | GWLAAALGTN | 
    300:
    LQVQFWHKTV | GILPSNCSDI | WQVLNVNQIA | FPGPAGPSFN | STEDHSKWCV | 
    350:
    SPKGPWTCVG | DMNRNQGEEQ | RGGGTLCAQL | PALWKAFQPL | VKNYQPCNGM | 
    360:
    ARKPSRAYKI | 
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    KEGG:
    UniGene:
    MIM:
    Pfam:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Human Deoxyribonuclease-2-alpha
    ELISA Kit for Human Deoxyribonuclease-2-alpha
    ELISA Kit for Human Deoxyribonuclease-2-alpha
    ELISA Kit for Human Deoxyribonuclease-2-alpha
    ELISA Kit for Human Deoxyribonuclease-2-alpha
    CLIA Kit for Human Deoxyribonuclease-2-alpha
    CLIA Kit for Human Deoxyribonuclease-2-alpha
    CLIA Kit for Human Deoxyribonuclease-2-alpha
    CLIA Kit for Human Deoxyribonuclease-2-alpha
    CLIA Kit for Human Deoxyribonuclease-2-alpha
    Polyclonal Antibody for Human Deoxyribonuclease-2-alpha
    Polyclonal Antibody for Human Deoxyribonuclease-2-alpha
    Polyclonal Antibody for Human Deoxyribonuclease-2-alpha
    Polyclonal Antibody for Human Deoxyribonuclease-2-alpha
    Polyclonal Antibody for Human Deoxyribonuclease-2-alpha
    Monoclonal Antibody for Human Deoxyribonuclease-2-alpha
    Monoclonal Antibody for Human Deoxyribonuclease-2-alpha
    Monoclonal Antibody for Human Deoxyribonuclease-2-alpha
    Monoclonal Antibody for Human Deoxyribonuclease-2-alpha
    Monoclonal Antibody for Human Deoxyribonuclease-2-alpha
    Protein for Human Deoxyribonuclease-2-alpha
    Protein for Human Deoxyribonuclease-2-alpha
    Protein for Human Deoxyribonuclease-2-alpha
    Protein for Human Deoxyribonuclease-2-alpha
    Protein for Human Deoxyribonuclease-2-alpha

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Structure and organization of the human deoxyribonuclease II (DNase II) gene."
      Yasuda T. , Takeshita H. , Iida R. , Tsutsumi S. , Nakajima T. , Hosomi O. , Nakashima Y. , Mori S. , Kishi K.
      Ann. Hum. Genet.62:299-305(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    2. 2.
      "Cloning of cDNAs encoding porcine and human DNase II."
      Shiokawa D. , Tanuma S.
      Biochem. Biophys. Res. Commun.247:864-869(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    3. 3.
      "Molecular cloning and characterization of human and murine DNase II."
      Baker K.P. , Baron W.F. , Henzel W.J. , Spencer S.A.
      Gene215:281-289(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    4. 4.
      "The cloning and expression of human deoxyribonuclease II. A possible role in apoptosis."
      Krieser R.J. , Eastman A.
      J. Biol. Chem.273:30909-30914(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    5. 5.
      "Molecular cloning of the cDNA encoding human deoxyribonuclease II."
      Yasuda T. , Takeshita H. , Iida R. , Nakajima T. , Hosomi O. , Nakashima Y. , Kishi K.
      J. Biol. Chem.273:2610-2616(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    6. 6.
      "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N. , Chen X. , Rolfs A. , Halleck A. , Hines L. , Eisenstein S. , Koundinya M. , Raphael J. , Moreira D. , Kelley T. , LaBaer J. , Lin Y. , Phelan M. , Farmer A.
      Submitted (2003-05) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
    7. 7.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
      tissue: Brain.
    8. 8.
      "The DNA sequence and biology of human chromosome 19."
      Grimwood J. , Gordon L.A. , Olsen A.S. , Terry A. , Schmutz J. , Lamerdin J.E. , Hellsten U. , Goodstein D. , Couronne O. , Tran-Gyamfi M. , Aerts A. , Altherr M. , Ashworth L. , Bajorek E. , Black S. , Branscomb E. , Caenepeel S. , Carrano A.V. , more...
      Nature428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    9. 9.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    10. 10.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Muscle.
    11. 11.
      "Revised structure of the active form of human deoxyribonuclease IIalpha."
      MacLea K.S. , Krieser R.J. , Eastman A.
      Biochem. Biophys. Res. Commun.292:415-421(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: LACK OF PROTEOLYTIC PROCESSING;GLYCOSYLATION
    12. 12.
      "Structural requirements of human DNase II alpha for formation of the active enzyme: the role of the signal peptide, N-glycosylation, and disulphide bridging."
      MacLea K.S. , Krieser R.J. , Eastman A.
      Biochem. J.371:867-876(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS OF CYS-19; ASN-86; CYS-151; CYS-159; ASN-212; ASN-266; CYS-267; ASN-290; CYS-299; CYS-308; CYS-327 AND CYS-347;GLYCOSYLATION;DISULFIDE BONDS
    13. 13.
      "A family history of deoxyribonuclease II: surprises from Trichinella spiralis and Burkholderia pseudomallei."
      MacLea K.S. , Krieser R.J. , Eastman A.
      Gene305:1-12(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS OF HIS-295
    14. 14.
      "Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry."
      Zhang H. , Li X.-J. , Martin D.B. , Aebersold R.
      Nat. Biotechnol.21:660-666(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION AT ASN-212
    15. 15.
      "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
      Chen R. , Jiang X. , Sun D. , Han G. , Wang F. , Ye M. , Wang L. , Zou H.
      J. Proteome Res.8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-212
      tissue: Liver.
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