Gene name:
Appl1 (Dip13a;Kiaa1428) ;
Protein name:
DCC-interacting protein 13-alpha (Dip13-alpha) ;
Alternative:
Adapter protein containing PH domain, PTB domain and leucine zipper motif 1 ;
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Binds RAB5A/Rab5 through an N-terminal domain. This interaction is essential for its recruitment to endosomal membranes as well as its role in cell proliferation. Binds DCC and the catalytic domain of the inactive form of AKT2 through its PID domain. Binds PIK3CA and subunits of the NuRD/MeCP1 complex (By similarity). Interacts with OCRL.
Function:
Required for the regulation of cell proliferation in response to extracellular signals from an early endosomal compartment. Links Rab5 to nuclear signal transduction.
Subcellular Location:
Early endosome membrane
Peripheral membrane protein
Nucleus
Early endosomal membrane-bound and nuclear. Translocated into the nucleus upon release from endosomal membranes following internalization of EGF.
Protein Attributes:
50:
MPGIDKLPIE | ETLEDSPQTR | SLLGVFEEDA | TAISNYMNQL | YQAMHRIYDA |
100:
QNELSAATHL | TSKLLKEYEK | QRFPLGGDDE | VMSSTLQQFS | KVIDELSSCH |
150:
AVLSTQLADA | MMFPISQFKE | RDLKEILTLK | EVFQIASNDH | DAAINRYSRL |
200:
SKKRENDKVK | YEVTEDVYTS | RKKQHQTMMH | YFCALNTLQY | KKKIALLEPL |
250:
LGYMQAQISF | FKMGSENLNG | QLEEFLANIG | TSVQNVRREM | DGDVETMQQT |
300:
IEDLEVASDP | LYLPDPDPTK | FPINRNLTRK | AGYLNARNKT | GLVSSTWDRQ |
350:
FYFTQGGNLM | SQARGDVAGG | LAMDIDNCSV | MAVDCEDRRY | CFQITSFDGK |
400:
KSSILQAESK | KDHEEWICTI | NNISKQIYLS | ENPEETAARV | NQSALEAVTP |
450:
SPSFQQRHES | LRPGGQSRPP | TARTSSSGSL | GSESTNLAAL | SLDSLVAPDT |
500:
PIQFDIISPV | CEDQPGQAKA | FGQGGRRTNP | FGESGGSTKS | ETEDSILHQL |
550:
FIVRFLGSME | VKSDDHPDVV | YETMRQILAA | RAIHNIFRMT | ESHLLVTCDC |
600:
LKLIDPQTQV | TRLTFPLPCV | VLYATHQENK | RLFGFVLRTS | GGRSESNLSS |
650:
VCYIFESNNE | GEKICDSVGL | AKQIALHAEL | DRRASEKQKE | IERVKEKQQK |
700:
ELSKQKQIEK | DLEEQSRLIA | ASSRPNQAGS | EGQLVLSSSQ | SEESDLGEEG |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
ELISA Kit for Mouse Dip13-alpha
ELISA Kit for Mouse Dip13-alpha
CLIA Kit for Mouse Dip13-alpha
CLIA Kit for Mouse Dip13-alpha
Polyclonal Antibody for Mouse Dip13-alpha
Polyclonal Antibody for Mouse Dip13-alpha
Monoclonal Antibody for Mouse Dip13-alpha
Monoclonal Antibody for Mouse Dip13-alpha
Protein for Mouse Dip13-alpha
Protein for Mouse Dip13-alpha
R&D Technical Data
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
Precision
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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
Recovery
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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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Linearity
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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
References
1.
"Cloning of mouse DIP13 alpha and beta."
Chen Y.Q.
Submitted (2002-05) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
2.
"The transcriptional landscape of the mammalian genome."
Carninci P.
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more...
Science309:1559-1563(2005)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain :
C57BL/6J .
strain :
DBA/2 .
tissue :
Cecum .
tissue :
Corpora quadrigemina .
tissue :
Embryonic stem cell .
tissue :
Hippocampus .
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue :
Limb .
tissue :
Mammary gland .
4.
"Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
Okazaki N.
,
Kikuno R.
,
Ohara R.
,
Inamoto S.
,
Koseki H.
,
Hiraoka S.
,
Saga Y.
,
Seino S.
,
Nishimura M.
,
Kaisho T.
,
Hoshino K.
,
Kitamura H.
,
Nagase T.
,
Ohara O.
,
Koga H.
DNA Res.11:205-218(2004)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 485-707
tissue :
Pancreatic islet .
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Embryonic brain .
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Liver .
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH OCRL