DSCAM ELISA Kit for Human(Homo sapiens) | EIAab.comDSCAM ELISA Kit for Human(Homo sapiens) | EIAab.com

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DSCAM (Gene name),

Down syndrome cell adhesion molecule (Protein name ), DSCAM_HUMAN from NCBI database.

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General Annotation

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Antigen Annotation

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3D

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Predicted Eptitope

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Vaild Sequence

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Gene name:

DSCAM;

Protein name:

Down syndrome cell adhesion molecule;

Alternative:

CHD2;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Interacts with DCC; the interaction is abolished in response to NTN1 (By similarity). Probably found in a ternary complex composed of DSCAM, PAK1 and RAC1. Interacts (via extracellular domain) with NTN1. Interacts (via cytoplasmic domain) with PAK1; the interaction is direct and enhanced in presence of RAC1. Interacts with RAC1; the interaction requires PAK1.

Function:

Cell adhesion molecule that plays a role in neuronal self-avoidance. Promotes repulsion between specific neuronal processes of either the same cell or the same subtype of cells. Mediates within retinal amacrine and ganglion cell subtypes both isoneuronal self-avoidance for creating an orderly dendritic arborization and heteroneuronal self-avoidance to maintain the mosaic spacing between amacrine and ganglion cell bodies. Receptor for netrin required for axon guidance independently of and in collaboration with the receptor DCC. In spinal chord development plays a role in guiding commissural axons projection and pathfinding across the ventral midline to reach the floor plate upon ligand binding. Enhances netrin-induced phosphorylation of PAK1 and FYN. Mediates intracellular signaling by stimulating the activation of MAPK8 and MAP kinase p38.

Subcellular Location:

Isoform Short Secreted

Protein Attributes:

Sequence length:

2012

Sequence:

50:

MWILALSLFQ | SFANVFSEDL | HSSLYFVNAS | LQEVVFASTT | GTLVPCPAAG |

100:

IPPVTLRWYL | ATGEEIYDVP | GIRHVHPNGT | LQIFPFPPSS | FSTLIHDNTY |

150:

YCTAENPSGK | IRSQDVHIKA | VLREPYTVRV | EDQKTMRGNV | AVFKCIIPSS |

200:

VEAYITVVSW | EKDTVSLVSG | SRFLITSTGA | LYIKDVQNED | GLYNYRCITR |

250:

HRYTGETRQS | NSARLFVSDP | ANSAPSILDG | FDHRKAMAGQ | RVELPCKALG |

300:

HPEPDYRWLK | DNMPLELSGR | FQKTVTGLLI | ENIRPSDSGS | YVCEVSNRYG |

350:

TAKVIGRLYV | KQPLKATISP | RKVKSSVGSQ | VSLSCSVTGT | EDQELSWYRN |

400:

GEILNPGKNV | RITGINHENL | IMDHMVKSDG | GAYQCFVRKD | KLSAQDYVQV |

450:

VLEDGTPKII | SAFSEKVVSP | AEPVSLMCNV | KGTPLPTITW | TLDDDPILKG |

500:

GSHRISQMIT | SEGNVVSYLN | ISSSQVRDGG | VYRCTANNSA | GVVLYQARIN |

550:

VRGPASIRPM | KNITAIAGRD | TYIHCRVIGY | PYYSIKWYKN | SNLLPFNHRQ |

600:

VAFENNGTLK | LSDVQKEVDE | GEYTCNVLVQ | PQLSTSQSVH | VTVKVPPFIQ |

650:

PFEFPRFSIG | QRVFIPCVVV | SGDLPITITW | QKDGRPIPGS | LGVTIDNIDF |

700:

TSSLRISNLS | LMHNGNYTCI | ARNEAAAVEH | QSQLIVRVPP | KFVVQPRDQD |

750:

GIYGKAVILN | CSAEGYPVPT | IVWKFSKGAG | VPQFQPIALN | GRIQVLSNGS |

800:

LLIKHVVEED | SGYYLCKVSN | DVGADVSKSM | YLTVKIPAMI | TSYPNTTLAT |

850:

QGQKKEMSCT | AHGEKPIIVR | WEKEDRIINP | EMARYLVSTK | EVGEEVISTL |

900:

QILPTVREDS | GFFSCHAINS | YGEDRGIIQL | TVQEPPDPPE | IEIKDVKART |

950:

ITLRWTMGFD | GNSPITGYDI | ECKNKSDSWD | SAQRTKDVSP | QLNSATIIDI |

1000:

HPSSTYSIRM | YAKNRIGKSE | PSNELTITAD | EAAPDGPPQE | VHLEPISSQS |

1050:

IRVTWKAPKK | HLQNGIIRGY | QIGYREYSTG | GNFQFNIISV | DTSGDSEVYT |

1100:

LDNLNKFTQY | GLVVQACNRA | GTGPSSQEII | TTTLEDVPSY | PPENVQAIAT |

1150:

SPESISISWS | TLSKEALNGI | LQGFRVIYWA | NLMDGELGEI | KNITTTQPSL |

1200:

ELDGLEKYTN | YSIQVLAFTR | AGDGVRSEQI | FTRTKEDVPG | PPAGVKAAAA |

1250:

SASMVFVSWL | PPLKLNGIIR | KYTVFCSHPY | PTVISEFEAS | PDSFSYRIPN |

1300:

LSRNRQYSVW | VVAVTSAGRG | NSSEIITVEP | LAKAPARILT | FSGTVTTPWM |

1350:

KDIVLPCKAV | GDPSPAVKWM | KDSNGTPSLV | TIDGRRSIFS | NGSFIIRTVK |

1400:

AEDSGYYSCI | ANNNWGSDEI | ILNLQVQVPP | DQPRLTVSKT | TSSSITLSWL |

1450:

PGDNGGSSIR | GYILQYSEDN | SEQWGSFPIS | PSERSYRLEN | LKCGTWYKFT |

1500:

LTAQNGVGPG | RISEIIEAKT | LGKEPQFSKE | QELFASINTT | RVRLNLIGWN |

1550:

DGGCPITSFT | LEYRPFGTTV | WTTAQRTSLS | KSYILYDLQE | ATWYELQMRV |

1600:

CNSAGCAEKQ | ANFATLNYDG | STIPPLIKSV | VQNEEGLTTN | EGLKMLVTIS |

1650:

CILVGVLLLF | VLLLVVRRRR | REQRLKRLRD | AKSLAEMLMS | KNTRTSDTLS |

1700:

KQQQTLRMHI | DIPRAQLLIE | ERDTMETIDD | RSTVLLTDAD | FGEAAKQKSL |

1750:

TVTHTVHYQS | VSQATGPLVD | VSDARPGTNP | TTRRNAKAGP | TARNRYASQW |

1800:

TLNRPHPTIS | AHTLTTDWRL | PTPRAAGSVD | KESDSYSVSP | SQDTDRARSS |

1850:

MVSTESASST | YEELARAYEH | AKMEEQLRHA | KFTITECFIS | DTSSEQLTAG |

1900:

TNEYTDSLTS | STPSESGICR | FTASPPKPQD | GGRVMNMAVP | KAHRPGDLIH |

1950:

LPPYLRMDFL | LNRGGPGTSR | DLSLGQACLE | PQKSRTLKRP | TVLEPIPMEA |

2000:

ASSASSTREG | QSWQPGAVAT | LPQREGAELG | QAAKMSSSQE | SLLDSRGHLK |

2012:

GNNPYAKSYT | LV

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

String:

UniGene:

SMR:

KEGG:

MIM:

Pfam:

STRING:

9606.ENSP00000383303

Uniprot:

FOR

ELISA Kit for Human Down syndrome cell adhesion molecule

ELISA Kit for Human Down syndrome cell adhesion molecule

ELISA Kit for Human Down syndrome cell adhesion molecule

CLIA Kit for Human Down syndrome cell adhesion molecule

CLIA Kit for Human Down syndrome cell adhesion molecule

CLIA Kit for Human Down syndrome cell adhesion molecule

Polyclonal Antibody for Human Down syndrome cell adhesion molecule

Polyclonal Antibody for Human Down syndrome cell adhesion molecule

Polyclonal Antibody for Human Down syndrome cell adhesion molecule

Monoclonal Antibody for Human Down syndrome cell adhesion molecule

Monoclonal Antibody for Human Down syndrome cell adhesion molecule

Monoclonal Antibody for Human Down syndrome cell adhesion molecule

Protein for Human Down syndrome cell adhesion molecule

Protein for Human Down syndrome cell adhesion molecule

Protein for Human Down syndrome cell adhesion molecule

R&D Technical Data

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Precision

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Recovery

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Linearity

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References

1.

"DSCAM: a novel member of the immunoglobulin superfamily maps in a Down syndrome region and is involved in the development of the nervous system."
Yamakawa K. , Huot Y.-K. , Haendelt M.A. , Hubert R. , Chen X.-N. , Lyons G.E. , Korenberg J.R.
Hum. Mol. Genet.7:227-237(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];ALTERNATIVE SPLICING
tissue: Brain.
2.

"Down syndrome cell adhesion molecule DSCAM mediates homophilic intercellular adhesion."
Agarwala K.L. , Nakamura S. , Tsutsumi Y. , Yamakawa K.
Brain Res. Mol. Brain Res.79:118-126(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];FUNCTION
3.

"The DNA sequence of human chromosome 21."
Hattori M. , Fujiyama A. , Taylor T.D. , Watanabe H. , Yada T. , Park H.-S. , Toyoda A. , Ishii K. , Totoki Y. , Choi D.-K. , Groner Y. , Soeda E. , Ohki M. , Takagi T. , Sakaki Y. , Taudien S. , Blechschmidt K. , Polley A. , more...
Nature405:311-319(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
4.

"The Down syndrome cell adhesion molecule (DSCAM) interacts with and activates Pak."
Li W. , Guan K.L.
J. Biol. Chem.279:32824-32831(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH PAK1 AND RAC1
5.

"DSCAM is a netrin receptor that collaborates with DCC in mediating turning responses to netrin-1."
Ly A. , Nikolaev A. , Suresh G. , Zheng Y. , Tessier-Lavigne M. , Stein E.
Cell133:1241-1254(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
6.

"DSCAM functions as a netrin receptor in commissural axon pathfinding."
Liu G. , Li W. , Wang L. , Kar A. , Guan K.L. , Rao Y. , Wu J.Y.
Proc. Natl. Acad. Sci. U.S.A.106:2951-2956(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH NTN1;PHOSPHORYLATION

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