Dscam;

Down syndrome cell adhesion molecule homolog;

Rat (Rattus norvegicus). 

Probably found in a ternary complex composed of DSCAM, PAK1 and RAC1. Interacts (via cytoplasmic domain) with PAK1; the interaction is direct and enhanced in presence of RAC1. Interacts with RAC1; the interaction requires PAK1. Interacts (via extracellular domain) with NTN1. Interacts with DCC; the interaction is abolished in response to NTN1.

Cell adhesion molecule that plays a role in neuronal self-avoidance. Promotes repulsion between specific neuronal processes of either the same cell or the same subtype of cells. Mediates within retinal amacrine and ganglion cell subtypes both isoneuronal self-avoidance for creating an orderly dendritic arborization and heteroneuronal self-avoidance to maintain the mosaic spacing between amacrine and ganglion cell bodies. In spinal chord development plays a role in guiding commissural axons projection and pathfinding across the ventral midline to reach the floor plate upon ligand binding. Enhances netrin-induced phosphorylation of PAK1 and FYN. Mediates intracellular signaling by stimulating the activation of MAPK8 and MAP kinase p38 (By similarity). Receptor for netrin required for axon guidance independently of and in collaboration with the receptor DCC.

Cell membrane Single-pass type I membrane protein Localized in the soma, cell membrane, axon and growth cone of dissociated commissural axons.

2013

N/A

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Q8VHZ8

rno:171119

Rn.24399

Q8VHZ8

10116.ENSRNOP00000002215

PF00041