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Index > Protein center > DSCAML1(Gene name) > Human
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  • DSCAML1 (Gene name),
  • Down syndrome cell adhesion molecule-like protein 1 (Protein name ),  DSCL1_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    DSCAML1(DSCAM2;KIAA1132);
    Protein name:
    Down syndrome cell adhesion molecule-like protein 1;
    Alternative:
    Down syndrome cell adhesion molecule 2;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Cell adhesion molecule that plays a role in neuronal self-avoidance. Promotes repulsion between specific neuronal processes of either the same cell or the same subtype of cells. Promotes both isoneuronal self-avoidance for creating an orderly neurite arborization in retinal rod bipolar cells and heteroneuronal self-avoidance to maintain mosaic spacing between AII amacrine cells.
    Subcellular Location:
    Cell membrane Single-pass type I membrane protein
    Protein Attributes:
    Sequence length:
    2053
    Sequence:
    50:
    MWLVTFLLLL | DSLHKARPED | VGTSLYFVND | SLQQVTFSSS | VGVVVPCPAA | 
    100:
    GSPSAALRWY | LATGDDIYDV | PHIRHVHANG | TLQLYPFSPS | AFNSFIHDND | 
    150:
    YFCTAENAAG | KIRSPNIRVK | AVFREPYTVR | VEDQRSMRGN | VAVFKCLIPS | 
    200:
    SVQEYVSVVS | WEKDTVSIIP | EHRFFITYHG | GLYISDVQKE | DALSTYRCIT | 
    250:
    KHKYSGETRQ | SNGARLSVTD | PAESIPTILD | GFHSQEVWAG | HTVELPCTAS | 
    300:
    GYPIPAIRWL | KDGRPLPADS | RWTKRITGLT | ISDLRTEDSG | TYICEVTNTF | 
    350:
    GSAEATGILM | VIDPLHVTLT | PKKLKTGIGS | TVILSCALTG | SPEFTIRWYR | 
    400:
    NTELVLPDEA | ISIRGLSNET | LLITSAQKSH | SGAYQCFATR | KAQTAQDFAI | 
    450:
    IALEDGTPRI | VSSFSEKVVN | PGEQFSLMCA | AKGAPPPTVT | WALDDEPIVR | 
    500:
    DGSHRTNQYT | MSDGTTISHM | NVTGPQIRDG | GVYRCTARNL | VGSAEYQARI | 
    550:
    NVRGPPSIRA | MRNITAVAGR | DTLINCRVIG | YPYYSIKWYK | DALLLPDNHR | 
    600:
    QVVFENGTLK | LTDVQKGMDE | GEYLCSVLIQ | PQLSISQSVH | VAVKVPPLIQ | 
    650:
    PFEFPPASIG | QLLYIPCVVS | SGDMPIRITW | RKDGQVIISG | SGVTIESKEF | 
    700:
    MSSLQISSVS | LKHNGNYTCI | ASNAAATVSR | ERQLIVRVPP | RFVVQPNNQD | 
    750:
    GIYGKAGVLN | CSVDGYPPPK | VMWKHAKGSG | NPQQYHPVPL | TGRIQILPNS | 
    800:
    SLLIRHVLEE | DIGYYLCQAS | NGVGTDISKS | MFLTVKIPAM | ITSHPNTTIA | 
    850:
    IKGHAKELNC | TARGERPIII | RWEKGDTVID | PDRVMRYAIA | TKDNGDEVVS | 
    900:
    TLKLKPADRG | DSVFFSCHAI | NSYGEDRGLI | QLTVQEPPDP | PELEIREVKA | 
    950:
    RSMNLRWTQR | FDGNSIITGF | DIEYKNKSDS | WDFKQSTRNI | SPTINQANIV | 
    1000:
    DLHPASVYSI | RMYSFNKIGR | SEPSKELTIS | TEEAAPDGPP | MDVTLQPVTS | 
    1050:
    QSIQVTWKAP | KKELQNGVIR | GYQIGYRENS | PGSNGQYSIV | EMKATGDSEV | 
    1100:
    YTLDNLKKFA | QYGVVVQAFN | RAGTGPSSSE | INATTLEDVP | SQPPENVRAL | 
    1150:
    SITSDVAVIS | WSEPPRSTLN | GVLKGYRVIF | WSLYVDGEWG | EMQNITTTRE | 
    1200:
    RVELRGMEKF | TNYSVQVLAY | TQAGDGVRSS | VLYIQTKEDV | PGPPAGIKAV | 
    1250:
    PSSASSVVVS | WLPPTKPNGV | IRKYTIFCSS | PGSGQPAPSE | YETSPEQLFY | 
    1300:
    RIAHLNRGQQ | YLLWVAAVTS | AGRGNSSEKV | TIEPAGKAPA | KIISFGGTVT | 
    1350:
    TPWMKDVRLP | CNSVGDPAPA | VKWTKDSEDS | AIPVSMDGHR | LIHTNGTLLL | 
    1400:
    RAVKAEDSGY | YTCTATNTGG | FDTIIVNLLV | QVPPDQPRLT | VSKTSASSIT | 
    1450:
    LTWIPGDNGG | SSIRGFVLQY | SVDNSEEWKD | VFISSSERSF | KLDSLKCGTW | 
    1500:
    YKVKLAAKNS | VGSGRISEII | EAKTHGREPS | FSKDQHLFTH | INSTHARLNL | 
    1550:
    QGWNNGGCPI | TAIVLEYRPK | GTWAWQGLRA | NSSGEVFLTE | LREATWYELR | 
    1600:
    MRACNSAGCG | NETAQFATLD | YDGSTIPPIK | SAQGEGDDVK | KLFTIGCPVI | 
    1650:
    LATLGVALLF | IVRKKRKEKR | LKRLRDAKSL | AEMLISKNNR | SFDTPVKGPP | 
    1700:
    QGPRLHIDIP | RVQLLIEDKE | GIKQLGDDKA | TIPVTDAEFS | QAVNPQSFCT | 
    1750:
    GVSLHHPTLI | QSTGPLIDMS | DIRPGTNPVS | RKNVKSAHST | RNRYSSQWTL | 
    1800:
    TKCQASTPAR | TLTSDWRTVG | SQHGVTVTES | DSYSASLSQD | TDKGRNSMVS | 
    1850:
    TESASSTYEE | LARAYEHAKL | EEQLQHAKFE | ITECFISDSS | SDQMTTGTNE | 
    1900:
    NADSMTSMST | PSEPGICRFT | ASPPKPQDAD | RGKNVAVPIP | HRANKSDYCN | 
    1950:
    LPLYAKSEAF | FRKADGREPC | PVVPPREASI | RNLARTYHTQ | ARHLTLDPAS | 
    2000:
    KSLGLPHPGA | PAAASTATLP | QRTLAMPAPP | AGTAPPAPGP | TPAEPPTAPS | 
    2050:
    AAPPAPSTEP | PRAGGPHTKM | GGSRDSLLEM | STSGVGRSQK | QGAGAYSKSY | 
    2053:
    TLV
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    KEGG:
    SMR:
    UniGene:
    String:
    MIM:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Human Down syndrome cell adhesion molecule-like protein 1
    ELISA Kit for Human Down syndrome cell adhesion molecule-like protein 1
    CLIA Kit for Human Down syndrome cell adhesion molecule-like protein 1
    CLIA Kit for Human Down syndrome cell adhesion molecule-like protein 1
    Polyclonal Antibody for Human Down syndrome cell adhesion molecule-like protein 1
    Polyclonal Antibody for Human Down syndrome cell adhesion molecule-like protein 1
    Monoclonal Antibody for Human Down syndrome cell adhesion molecule-like protein 1
    Monoclonal Antibody for Human Down syndrome cell adhesion molecule-like protein 1
    Protein for Human Down syndrome cell adhesion molecule-like protein 1
    Protein for Human Down syndrome cell adhesion molecule-like protein 1

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Cloning and functional characterization of DSCAML1, a novel DSCAM-like cell adhesion molecule that mediates homophilic intercellular adhesion."
      Agarwala K.L. , Ganesh S. , Tsutsumi Y. , Suzuki T. , Amano K. , Yamakawa K.
      Biochem. Biophys. Res. Commun.285:760-772(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);FUNCTION;SUBCELLULAR LOCATION;TISSUE SPECIFICITY
      tissue: Fetal brain.
    2. 2.
      "Mammalian DSCAMs: roles in the development of the spinal cord, cortex, and cerebellum?"
      Barlow G.M. , Micales B. , Chen X.-N. , Lyons G.E. , Korenberg J.R.
      Biochem. Biophys. Res. Commun.293:881-891(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);ALTERNATIVE SPLICING;TISSUE SPECIFICITY
    3. 3.
      "DSCAML1, a novel member of the immunoglobulin superfamily."
      Lin S. , Wang Z. , Ying K. , Xie Y. , Mao Y.
      Submitted (2000-09) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2)
      tissue: Fetal brain.
    4. 4.
      "Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain."
      Hirosawa M. , Nagase T. , Ishikawa K. , Kikuno R. , Nomura N. , Ohara O.
      DNA Res.6:329-336(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Brain.
    5. 5.
      "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
      Nakajima D. , Okazaki N. , Yamakawa H. , Kikuno R. , Ohara O. , Nagase T.
      DNA Res.9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SEQUENCE REVISION
    6. 6.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    7. 7.
      "Solution structure of the second FNIII domain of DSCAML1 protein."
      RIKEN structural genomics initiative (RSGI)
      Submitted (2005-02) to the PDB data bank
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 979-1087
    8. 8.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS [LARGE SCALE ANALYSIS] ILE-659 AND ILE-1702
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