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Index > Protein center > DUOX1(Gene name) > Dog
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  • DUOX1 (Gene name),
  • Dual oxidase 1 (Protein name ),  DUOX1_CANFA from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Gene name:
    DUOX1(THOX1);
    Protein name:
    Dual oxidase 1;
    Alternative:
    NADPH thyroid oxidase 1(Thyroid oxidase 1);
    Organism:
    Dog (Canis familiarisCanis lupus familiaris). 
    General Annotation
    Sub Unit:
    Interacts with TPO and CYBA (By similarity). Interacts with TXNDC11.
    Function:
    Generates hydrogen peroxide which is required for the activity of thyroid peroxidase/TPO and lactoperoxidase/LPO. Plays a role in thyroid hormones synthesis and lactoperoxidase-mediated antimicrobial defense at the surface of mucosa. May have its own peroxidase activity through its N-terminal peroxidase-like domain.
    Subcellular Location:
    Apical cell membrane Multi-pass membrane protein Localizes to the apical membrane of epithelial cells.
    Protein Attributes:
    Sequence length:
    1551
    Sequence:
    50:
    MGFCLALTWT | FLVGSWTSMG | AQKPISWEVQ | RFDGWYNNLM | EHKWGSKGSR | 
    100:
    LQRLVPASYA | DGVYQPLGEP | HLPNPRDLSN | AAMRGPAGQA | SLRNRTVLGV | 
    150:
    FFGYHVLSDL | VSVETPGCPA | EFLNIRIPPG | DPVFDPNGRG | DVVLPFQRSR | 
    200:
    WDPESGQSPS | NPRDLTNAVT | GWLDGSAIYG | SSHSWSDALR | SFSGGQLASG | 
    250:
    PDPAFPRNAQ | PPLLMWSAPD | PASGQRGPGG | LYAFGAERGN | RDPFLQALGL | 
    300:
    LWFRYHNLCA | QRLARQHPHW | GDEELFQHAR | KRVIATYQNI | ALYEWLPSFL | 
    350:
    QQAPVKYAGY | NPFLDPSISP | EFLVASEQFF | STMVPPGIYM | RNASCHFQEV | 
    400:
    INRNSSISRA | LRVCNSYWSR | KHPNLRRAED | VDALLLGMAS | QIAEREDHVV | 
    450:
    VEDVLDFWPG | SLKFSRTDHV | AGCLQRGRDL | GLPSYTKARA | ALGLPPITRW | 
    500:
    QDINPALSQN | NHTVLEATAA | LYNQDLSQLE | LLPGGLLESH | GDPGPLFSAI | 
    550:
    VLNQFVRLRD | GDRYWFENTR | NGLFSEEEIA | EIRNTSLRDV | LVAVTNMNPS | 
    600:
    TLQPNVFFWH | MGDPCPQPRQ | LSTQGLPACA | PSTMQDYFEG | SGFGFGVTIG | 
    650:
    TLCCFPLVSL | LSAWIVARLR | KKNFKKLQGQ | DRKSVMSEKL | VGGMEALEWQ | 
    700:
    GHKEPCRPVL | VHLQPGQICV | VDGRLSVLRT | IQLRPPQQVN | LILSGNRGRR | 
    750:
    ALLLKIPKEY | DLVLLFNLEE | ERQVLVENLR | GALKESGLKF | QEWELREQEL | 
    800:
    MRTAVTRQQR | SHLLETFFRH | LFSQVLDIDQ | ADAGTLPLDS | SQKVQEALTC | 
    850:
    ELSRAEFAES | LGLKPQDMFV | ESMFSLADKD | GNGYLSFREF | LDILVVFMKG | 
    900:
    SPEEKSRLMF | RMYDFDGNGL | ISKDEFIRML | RSFIEISNNC | LSKAQLTEVV | 
    950:
    ESMFRESGFQ | DKEELTWEDF | HFMLRDHDSE | LRFTQLCVRG | VEVPEVIKDL | 
    1000:
    CRRASYISQE | KICPSPRVSA | RCPHSNTEVE | WTPQRLQCPV | DTDPPQEIRR | 
    1050:
    RFGKKVTSFQ | PLLFTEAQRE | KFQRSRRHQT | LQQFKRFIEN | YRRHIGCVAV | 
    1100:
    FYAITGGLFL | ERAYYYAFGA | HHMGITDTTR | VGIILSRGTA | ASISFMFSYI | 
    1150:
    LLTMCRNLIT | FLRETFLNRY | VPFDAAVDFH | RLIASTAIVL | TVLHSAGHVV | 
    1200:
    NVYLFSISPL | SVLSCLFPGL | FHNDGSEFPQ | KYYWWFFQTV | PGLTGVMLLL | 
    1250:
    VLAIMYVFAS | HHFRRHSFRG | FWLTHHLYIL | LYVLLIIHGS | FGLIQLPRFH | 
    1300:
    IFFLVPALIY | VGDKLVSLSR | KKVEISVVKA | ELLPSGVTHL | QFQRPQGFEY | 
    1350:
    KSGQWVQIAC | LALGTTEYHP | FTLTSAPHED | TLSLHIRAAG | PWTTRLREIY | 
    1400:
    SPPTGDGCAK | YPKLYLDGPF | GEGHQEWHKF | EVSVLVGGGI | GVTPFASILK | 
    1450:
    DLVFKSSVSC | QVFCKKIYFI | WVTRTQRQFE | WLADIIREVE | ENDCQDLVSV | 
    1500:
    HIYITQLAEK | FDLRTTMLYI | CERHFQKVLN | RSLFTGLRSI | THFGRPPFEP | 
    1550:
    FFKSLQEVHP | QVRKIGVFSC | GPPGMTKNVE | KACQLINRQD | RTHFSHHYEN | 
    1551:
    F
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    UniGene:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Dog Dual oxidase 1
    Cat.:
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    MSDS:
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    Packing:
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    Range:
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    MSDS:
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    ELISA Kit for Dog Dual oxidase 1
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    ELISA Kit for Dog Dual oxidase 1
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Dog Dual oxidase 1
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    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Dog Dual oxidase 1
    Cat.:
    U15381p
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Dog Dual oxidase 1
    Cat.:
    U15381d
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Dog Dual oxidase 1
    Cat.:
    U15381r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Dog Dual oxidase 1
    Polyclonal Antibody for Dog Dual oxidase 1
    Polyclonal Antibody for Dog Dual oxidase 1
    Cat.:
    P15381Rb-r
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Dog Dual oxidase 1
    Cat.:
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    Price:
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    Packing:
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    Monoclonal Antibody for Dog Dual oxidase 1
    Monoclonal Antibody for Dog Dual oxidase 1
    Monoclonal Antibody for Dog Dual oxidase 1
    Monoclonal Antibody for Dog Dual oxidase 1
    Protein for Dog Dual oxidase 1
    Protein for Dog Dual oxidase 1
    Protein for Dog Dual oxidase 1
    Protein for Dog Dual oxidase 1

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    References
    1. 1.
      "Cloning of two human thyroid cDNAs encoding new members of the NADPH oxidase family."
      De Deken X. , Wang D. , Many M.-C. , Costagliola S. , Libert F. , Vassart G. , Dumont J.E. , Miot F.
      J. Biol. Chem.275:23227-23233(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];TISSUE SPECIFICITY;INDUCTION
    2. 2.
      "Characterization of ThOX proteins as components of the thyroid H(2)O(2)-generating system."
      De Deken X. , Wang D. , Dumont J.E. , Miot F.
      Exp. Cell Res.273:187-196(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;CATALYTIC ACTIVITY;ENZYME REGULATION;GLYCOSYLATION
    3. 3.
      "Identification of a novel partner of duox: EFP1, a thioredoxin-related protein."
      Wang D. , De Deken X. , Milenkovic M. , Song Y. , Pirson I. , Dumont J.E. , Miot F.
      J. Biol. Chem.280:3096-3103(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TXNDC11
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