Gene name:
DXO (DOM3L;DOM3Z;NG6) ;
Protein name:
Decapping and exoribonuclease protein (DXO) ;
Alternative:
Dom-3 homolog Z ;
Organism:
Human (Homo sapiens).
General Annotation
Function:
Ribonuclease that specifically degrades pre-mRNAs with a defective 5' end cap and is part of a pre-mRNA capping quality control. Has decapping, pyrophosphohydrolase and 5'-3' exonuclease activities. Has decapping activity toward incomplete 5' end cap mRNAs such as unmethylated 5' end-capped RNA to release GpppN and 5' end monophosphate RNA. The 5' end monophosphate RNA is then degraded by the 5'-3' exoribonuclease activity, enabling this enzyme to decap and degrade incompletely capped mRNAs. Also possesses RNA 5'-pyrophosphohydrolase activity by hydrolyzing the 5' end triphosphate to release pyrophosphates.
Subcellular Location:
Nucleus
Protein Attributes:
50:
MDPRGTKRGA | EKTEVAEPRN | KLPRPAPSLP | TDPALYSGPF | PFYRRPSELG |
100:
CFSLDAQRQY | HGDARALRYY | SPPPTNGPGP | NFDLRDGYPD | RYQPRDEEVQ |
150:
ERLDHLLCWL | LEHRGRLEGG | PGWLAEAIVT | WRGHLTKLLT | TPYERQEGWQ |
200:
LAASRFQGTL | YLSEVETPNA | RAQRLARPPL | LRELMYMGYK | FEQYMCADKP |
250:
GSSPDPSGEV | NTNVAFCSVL | RSRLGSHPLL | FSGEVDCTDP | QAPSTQPPTC |
300:
YVELKTSKEM | HSPGQWRSFY | RHKLLKWWAQ | SFLPGVPNVV | AGFRNPDGFV |
350:
SSLKTFPTMK | MFEYVRNDRD | GWNPSVCMNF | CAAFLSFAQS | TVVQDDPRLV |
396:
HLFSWEPGGP | VTVSVHQDAP | YAFLPIWYVE | AMTQDLPSPP | KTPSPK
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Rat
Human
Bovine
Mouse
Polyclonal Antibody for Human DXO
Polyclonal Antibody for Human DXO
Polyclonal Antibody for Human DXO
Polyclonal Antibody for Human DXO
Monoclonal Antibody for Human DXO
Monoclonal Antibody for Human DXO
Monoclonal Antibody for Human DXO
Monoclonal Antibody for Human DXO
R&D Technical Data
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Precision
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Recovery
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Linearity
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA];VARIANT GLN-261
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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