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Index > Protein center > DXO(Gene name) > Human
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  • DXO (Gene name),
  • Decapping and exoribonuclease protein (Protein name ),  DXO_HUMAN from NCBI database.
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  • Gene name:
    DXO(DOM3L;DOM3Z;NG6);
    Protein name:
    Decapping and exoribonuclease protein(DXO);
    Alternative:
    Dom-3 homolog Z;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Ribonuclease that specifically degrades pre-mRNAs with a defective 5' end cap and is part of a pre-mRNA capping quality control. Has decapping, pyrophosphohydrolase and 5'-3' exonuclease activities. Has decapping activity toward incomplete 5' end cap mRNAs such as unmethylated 5' end-capped RNA to release GpppN and 5' end monophosphate RNA. The 5' end monophosphate RNA is then degraded by the 5'-3' exoribonuclease activity, enabling this enzyme to decap and degrade incompletely capped mRNAs. Also possesses RNA 5'-pyrophosphohydrolase activity by hydrolyzing the 5' end triphosphate to release pyrophosphates.
    Subcellular Location:
    Nucleus
    Protein Attributes:
    Sequence length:
    396
    Sequence:
    50:
    MDPRGTKRGA | EKTEVAEPRN | KLPRPAPSLP | TDPALYSGPF | PFYRRPSELG | 
    100:
    CFSLDAQRQY | HGDARALRYY | SPPPTNGPGP | NFDLRDGYPD | RYQPRDEEVQ | 
    150:
    ERLDHLLCWL | LEHRGRLEGG | PGWLAEAIVT | WRGHLTKLLT | TPYERQEGWQ | 
    200:
    LAASRFQGTL | YLSEVETPNA | RAQRLARPPL | LRELMYMGYK | FEQYMCADKP | 
    250:
    GSSPDPSGEV | NTNVAFCSVL | RSRLGSHPLL | FSGEVDCTDP | QAPSTQPPTC | 
    300:
    YVELKTSKEM | HSPGQWRSFY | RHKLLKWWAQ | SFLPGVPNVV | AGFRNPDGFV | 
    350:
    SSLKTFPTMK | MFEYVRNDRD | GWNPSVCMNF | CAAFLSFAQS | TVVQDDPRLV | 
    396:
    HLFSWEPGGP | VTVSVHQDAP | YAFLPIWYVE | AMTQDLPSPP | KTPSPK
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    SMR:
    MIM:
    Pfam:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Human DXO
    ELISA Kit for Human DXO
    ELISA Kit for Human DXO
    ELISA Kit for Human DXO
    CLIA Kit for Human DXO
    CLIA Kit for Human DXO
    CLIA Kit for Human DXO
    CLIA Kit for Human DXO
    Polyclonal Antibody for Human DXO
    Polyclonal Antibody for Human DXO
    Polyclonal Antibody for Human DXO
    Polyclonal Antibody for Human DXO
    Monoclonal Antibody for Human DXO
    Monoclonal Antibody for Human DXO
    Monoclonal Antibody for Human DXO
    Monoclonal Antibody for Human DXO
    Protein for Human DXO
    Protein for Human DXO
    Protein for Human DXO
    Protein for Human DXO

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    Precision
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    Linearity
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    References
    1. 1.
      "Four ubiquitously expressed genes, RD (D6S45)-SKI2W (SKIV2L)-DOM3Z-RP1 (D6S60E), are present between complement component genes factor B and C4 in the class III region of the HLA."
      Yang Z. , Shen L. , Dangel A.W. , Wu L.-C. , Yu C.Y.
      Genomics53:338-347(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];VARIANT THR-28;TISSUE SPECIFICITY
    2. 2.
      "Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse."
      Xie T. , Rowen L. , Aguado B. , Ahearn M.E. , Madan A. , Qin S. , Campbell R.D. , Hood L.
      Genome Res.13:2621-2636(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    3. 3.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    4. 4.
      "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J. , Palmer S.A. , Sims S.K. , Edwards C.A. , Ashurst J.L. , Wilming L. , Jones M.C. , Horton R. , Hunt S.E. , Scott C.E. , Gilbert J.G.R. , Clamp M.E. , Bethel G. , Milne S. , Ainscough R. , Almeida J.P. , Ambrose K.D. , Andrews T.D. , more...
      Nature425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA];VARIANT GLN-261
    5. 5.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Neuroblastoma.
      tissue: Retinoblastoma.
    6. 6.
      "Organizations and gene duplications of the human and mouse MHC complement gene clusters."
      Yang Z. , Yu C.Y.
      Exp. Clin. Immunogenet.17:1-17(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-106;VARIANT THR-28
    7. 7.
      "Unraveling regulation and new components of human P-bodies through a protein interaction framework and experimental validation."
      Zheng D. , Chen C.Y. , Shyu A.B.
      RNA17:1619-1634(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION
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