Gene name:
DNAH12 (DHC3;DLP12;DNAH12L;DNAH7L;DNAHC3;DNHD2;HDHC3;HL19) ;
Protein name:
Dynein heavy chain 12, axonemal ;
Alternative:
Axonemal dynein heavy chain 12-like protein ;Axonemal beta dynein heavy chain 12 ;Ciliary dynein heavy chain 12 ;Axonemal dynein heavy chain 7-like protein ;Dynein heavy chain domain-containing protein 2 ;Dynein heavy chain 7-like, axonemal ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Consists of at least two heavy chains and a number of intermediate and light chains.
Function:
Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly.
Subcellular Location:
Cytoplasm
cytoskeleton
cilium axoneme
Protein Attributes:
50:
MSDANKAAIA | AEKEALNLKL | PPIVHLPENI | GVDTPTQSKL | LKYRRSKEQQ |
100:
QKINQLVIDG | AKRNLDRTLG | KRTPLLPPPD | YPQTMTSEMK | KKGFNYIYMK |
150:
QCVESSPLVP | IQQEWLDHML | RLIPESLKEG | KEREELLESL | INEVSSDFEN |
200:
SMKRYLVQSV | LVKPPVKSLE | DEGGPLPESP | VGLDYSNPWH | SSYVQARNQI |
250:
FSNLHIIHPT | MKMLLDLGYT | TFADTVLLDF | TGIRAKGPID | CESLKTDLSI |
300:
QTRNAEEKIM | NTWYPKVINL | FTKKEALEGV | KPEKLDAFYS | CVSTLMSNQL |
350:
KDLLRRTVEG | FVKLFDPKDQ | QRLPIFKIEL | TFDDDKMEFY | PTFQDLEDNV |
400:
LSLVERIAEA | LQNVQTIPSW | LSGTSTPVNL | DTELPEHVLH | WAVDTLKAAV |
450:
HRNLEGARKH | YETYVEKYNW | LLDGTAVENI | ETFQTEDHTF | DEYTEFIEKF |
500:
LSLASEIMLL | PQWIHYTMVR | LDCEDLKTGL | TNKAKAFANI | LLNDIASKYR |
550:
KENECICSEF | EAIKEHALKV | PETTEEMMDL | ISYVEKARTV | GIEELILRIQ |
600:
ESKRQMSYFL | DVFLFPQEDL | ALNATVLMWP | RKINPIFDEN | DELIENAKHK |
650:
KENELMAKRE | KLILEIEKES | RRMEEFTEFA | ELERMQQYVT | DVRQLQKRIQ |
700:
ESEEAVQFIN | KEEELFKWEL | TKYPELDKLK | VNIEPYQKFF | NFVLKWQRSE |
750:
KRWMDGGFLD | LNGESMEADV | EEFSREIFKT | LKFFQTKLKK | ELQEKRKAAR |
800:
KRSLEEEKIE | EEPKDNATIT | MCRMRARHWK | QISEIVGYDL | TPDSGTTLRK |
850:
VLKLNLTPYL | EQFEVISAGA | SKEFSLEKAM | NTMIGTWEDI | AFHISLYRDT |
900:
GVCILSSVDE | IQAILDDQII | KTQTMRGSPF | IKPFEHEIKA | WEDRLIRIQE |
950:
TIDEWLKVQA | QWLYLEPIFC | SEDIMQQMPE | EGRQFQTVDR | HWRDIMKFCA |
1000:
KDPKVLAATS | LTGLLEKLQN | CNELLEKIMK | GLNAYLEKKR | LFFPRFFFLS |
1050:
NDEMLEILSE | TKDPLRVQPH | LKKCFEGIAK | LEFLPNLDIK | AMYSSEGERV |
1100:
ELIALISTSA | ARGAVEKWLI | QVEDLMLRSV | HDVIAAARLA | YPESARRDWV |
1150:
REWPGQVVLC | ISQMFWTSET | QEVISGGTEG | LKKYYKELQN | QLNEIVELVR |
1200:
GKLSKQTRTT | LGALVTIDVH | ARDVVMDMIK | MGVSHDTDFL | WLAQLRYYWE |
1250:
NENARVRIIN | CNVKYAYEYL | GNSPRLVITP | LTDRCYRTLI | GAFYLNLGGA |
1300:
PEGPAGTGKT | ETTKDLAKAL | AVQCVVFNCS | DGLDYLAMGK | FFKGLASSGA |
1350:
WACFDEFNRI | ELEVLSVVAQ | QILCIQRAIQ | QKLVVFVFEG | TELKLNPNCF |
1400:
VAITMNPGYA | GRSELPDNLK | VLFRTVAMMV | PNYALIAEIS | LYSYGFLNAR |
1450:
PLSVKIVMTY | RLCSEQLSSQ | FHYDYGMRAV | KAVLVAAGNL | KLKYPNENED |
1500:
ILLLRSIKDV | NEPKFLSHDI | PLFNGITSDL | FPGIKLPEAD | YHEFLECAHE |
1550:
ACNVHNLQPV | KFFLEKIIQT | YEMMIVRHGF | MLVGEPFAAK | TKVLHVLADT |
1600:
LTLMNEHGYG | EEEKVIYRTV | NPKSITMGQL | FGQFDPVSHE | WTDGIVANTF |
1650:
REFALSETPD | RKWVVFDGPI | DTLWIESMNT | VLDDNKKLCL | MSGEIIQMSP |
1700:
QMSLIFETMD | LSQASPATVS | RCGMIYLEPS | QLGWEPLVSS | WLNSLKGPLC |
1750:
EPEYQALLRG | LFAWLIPPSL | NQRVELFQLN | YLYTTIVSKI | LKILITFRIS |
1800:
NYFKYVPLKT | QCTFIKFFLH | QQACFIFSLI | WSIGGSCDTD | GRRVFDTFIR |
1850:
LIILGKDDEN | PVPDSVGKWE | CPFDEKGLVY | DYMYELKNKG | RWVHWNELIK |
1900:
NTNLGDKQIK | IQDIIVPTMD | TIRYTFLMDL | SITYAKPLLF | VGPTGTGKSV |
1950:
YVKDKLMNHL | EKDQYFPFYI | NLSARTSANQ | VQNIIMARLD | KRRKGVFGPP |
2000:
MGKKCIIFID | DMNMPALEKY | GAQPPIELLR | QFFDCGHWYD | LKDTSKITLV |
2050:
DIELIAAMGP | PGGGRNPVTP | RCIRHFNICS | INSFSDETMV | RIFSSIVAFY |
2100:
LRTHEFPPEY | FVIGNQIVNG | TMEIYKQSVE | NLLPTPTKSH | YTFNLRDFSR |
2150:
VIRGCLLIER | DAVANKHTMI | RLFVHEVLRV | FYDRLINDDD | RRWLFQLTKT |
2200:
VIKDHFKESF | HSIFSHLRKQ | NAPVTEEDLR | NLMFGDYMNP | DLEGDDRVYI |
2250:
EIPNIHHFSD | VVDQCLDEYN | QTHKTRMNLV | IFRYVLEHLS | RICRVLKQSG |
2300:
GNALLVGLGG | SGRQSLTRLA | TSMAKMHIFQ | PEISKSYGMN | EWREDMKSFI |
2350:
AVPVTNRIVD | NKSKILEKRL | RYLNDHFTYN | LYCNICRSLF | EKDKLLFSFL |
2400:
LCANLLLARK | EIEYQELMFL | LTGGVSLKSA | EKNPDPTWLQ | DKSWEEICRA |
2450:
SEFPAFRGLR | QHFCEHIYEW | REIYDSKEPH | NAKFPAPMDK | NLNELQKIII |
2500:
LRCLRPDKIT | PAITNYVTDK | LGKKFVEPPP | FDLTKSYLDS | NCTIPLIFVL |
2550:
SPGADPMASL | LKFANDKSMS | GNKFQAISLG | QGQGPIAAKM | IKAAIEEGTW |
2600:
VCLQNCHLAV | SWMPMLEKIC | EDFTSETCNS | SFRLWLTSYP | SSKFPVTILQ |
2650:
NGVKMTNEPP | TGLRLNLLQS | YLTDPVSDPE | FFKGCRGKEL | AWEKLLFGVC |
2700:
FFHALVQERK | KFGPLGWNIP | YGFNESDLRI | SIRQLQLFIN | EYDTIPFEAI |
2750:
SYLTGECNYG | GRVTDDWDRR | LLLTMLADFY | NLYIVENPHY | KFSPSGNYFA |
2800:
PPKGTYEDYI | EFIKKLPFTQ | HPEIFGLHEN | VDISKDLQQT | KTLFESLLLT |
2850:
QGGSKQTGAS | GSTDQILLEI | TKDILNKLPS | DFDIEMALRK | YPVRYEESMN |
2900:
TVLVQEMERF | NNLIITIRNT | LRDLEKAIKG | VVVMDSALEA | LSGSLLVGKV |
2950:
PEIWAKRSYP | SLKPLGSYIT | DFLARLNFLQ | DWYNSGKPCV | FWLSGFFFTQ |
3000:
AFLTGAMQNY | ARKYTTPIDL | LGYEFEVIPS | DTSDTSPEDG | VYIHGLYLDG |
3050:
ARWDRESGLL | AEQYPKLLFD | LMPIIWIKPT | QKSRIIKSDA | YVCPLYKTSE |
3092:
RKGTLSTTGH | STNFVIAMLL | KTDQPTRHWI | KRGVALLCQL | DD
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
Bovine
Rat
ELISA Kit for Human Dynein heavy chain 12, axonemal
ELISA Kit for Human Dynein heavy chain 12, axonemal
ELISA Kit for Human Dynein heavy chain 12, axonemal
ELISA Kit for Human Dynein heavy chain 12, axonemal
CLIA Kit for Human Dynein heavy chain 12, axonemal
CLIA Kit for Human Dynein heavy chain 12, axonemal
CLIA Kit for Human Dynein heavy chain 12, axonemal
CLIA Kit for Human Dynein heavy chain 12, axonemal
Polyclonal Antibody for Human Dynein heavy chain 12, axonemal
Polyclonal Antibody for Human Dynein heavy chain 12, axonemal
Polyclonal Antibody for Human Dynein heavy chain 12, axonemal
Polyclonal Antibody for Human Dynein heavy chain 12, axonemal
Monoclonal Antibody for Human Dynein heavy chain 12, axonemal
Monoclonal Antibody for Human Dynein heavy chain 12, axonemal
Monoclonal Antibody for Human Dynein heavy chain 12, axonemal
Monoclonal Antibody for Human Dynein heavy chain 12, axonemal
Protein for Human Dynein heavy chain 12, axonemal
Protein for Human Dynein heavy chain 12, axonemal
Protein for Human Dynein heavy chain 12, axonemal
Protein for Human Dynein heavy chain 12, axonemal
R&D Technical Data
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Precision
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Recovery
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Linearity
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more...
Nat. Genet.36:40-45(2004)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2; 3 AND 4);VARIANTS ALA-32 AND SER-2893
tissue :
Testis .
tissue :
Trachea .
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Weinstock G.
,
Gibbs R.A.
more...
Nature440:1194-1198(2006)
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PubMed ]
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Europe PMC ]
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Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF 1116-1311 (ISOFORM 1)